Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Rachel Ord"'
Autor:
Nicole Blaquiere, Cristina Lewis, Ping Wu, Steven T. Staben, Jeremy Murray, Aleks Kolesnikov, Robert Heald, Richard James Bull, Leslie Lee, Jones Mark, Lan Wang, Timothy P. Heffron, Jeff Wallin, Christian Weismann, Jodie Pang, Binqing Wei, Graham Elgin Jones, Wei Wei Prior, Alan G. Olivero, Daniel C. Gray, Rachel Ord, Kyle A. Edgar, Jim Nonomiya, Danette Dudley, Deepak Sampath, Neville James Mclean, Marcia Belvin, Laurent Salphati, Chudi Ndubaku, Stephen Price, Lionel Rouge, John Lesnick
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(9)
A series of suitable five-membered heterocyclic alternatives to thiophenes within a thienobenzoxepin class of PI3-kinase (PI3K) inhibitors was discovered. Specific thiazolobenzoxepin 8-substitution was identified that increased selectivity over PI3K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5724e89337ad63dc70f387ab6026b1e7
https://pubmed.ncbi.nlm.nih.gov/23540645
https://pubmed.ncbi.nlm.nih.gov/23540645
Autor:
Rachel Ord, Ian Hickson, Mark Frigerio, Niall M. B. Martin, Sophie Guiard, Keith Allan Menear, Marc Geoffrey Hummersone, Celine Cano-Soumillac, Jonathan J Hollick, Xiao-Ling Fan Cockcroft, Roger J. Griffin, Laurent Rigoreau, Graeme C. M. Smith, Bernard T. Golding, Ian R. Hardcastle, Caroline Richardson, David R. Newell, Ian Timothy Williams Matthews, Nicola J. Curtin
Publikováno v:
Journal of medicinal chemistry. 50(8)
Structure-activity relationships have been investigated for inhibition of DNA-dependent protein kinase (DNA-PK) and ATM kinase by a series of pyran-2-ones, pyran-4-ones, thiopyran-4-ones, and pyridin-4-ones. A wide range of IC50 values were observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fd293330798965b03b89cd699d51c3
https://pubmed.ncbi.nlm.nih.gov/17371003
https://pubmed.ncbi.nlm.nih.gov/17371003
Autor:
Jonathan J. Hollick, Laurent J. M. Rigoreau, Celine Cano-Soumillac, Xiaoling Cockcroft, Nicola J. Curtin, Mark Frigerio, Bernard T. Golding, Sophie Guiard, Ian R. Hardcastle, Ian Hickson, Marc G. Hummersone, Keith A. Menear, Niall M. B. Martin, Ian Matthews, David R. Newell, Rachel Ord, Caroline J. Richardson, Graeme C. M. Smith, Roger J. Griffin
Publikováno v:
Journal of Medicinal Chemistry; Apr2007, Vol. 50 Issue 8, p1958-1972, 15p