Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Rachel Cavill"'
Autor:
Jip W. T. M. de Kok, Frank van Rosmalen, Jacqueline Koeze, Frederik Keus, Sander M. J. van Kuijk, José Castela Forte, Ronny M. Schnabel, Rob G. H. Driessen, Thijs T. W. van Herpt, Jan-Willem E. M. Sels, Dennis C. J. J. Bergmans, Chris P. H. Lexis, William P. T. M. van Doorn, Steven J. R. Meex, Minnan Xu, Xavier Borrat, Rachel Cavill, Iwan C. C. van der Horst, Bas C. T. van Bussel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract We validated a Deep Embedded Clustering (DEC) model and its adaptation for integrating mixed datatypes (in this study, numerical and categorical variables). Deep Embedded Clustering (DEC) is a promising technique capable of managing extensiv
Externí odkaz:
https://doaj.org/article/867c03e4fffa4acaa2dd4b72c8bf55da
Autor:
Chang Lu, Marjo M. P. C. Donners, Julius B. J. de Baaij, Han Jin, Jeroen J. T. Otten, Marco Manca, Anton Jan van Zonneveld, J. Wouter Jukema, Adriaan Kraaijeveld, Johan Kuiper, Gerard Pasterkamp, Barend Mees, Judith C. Sluimer, Rachel Cavill, Joël M. H. Karel, Pieter Goossens, Erik A. L. Biessen
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe impact of cardiovascular disease (CVD) risk factors, encompassing various biological determinants and unhealthy lifestyles, on the functional dynamics of circulating monocytes—a pivotal cell type in CVD pathophysiology remains elusi
Externí odkaz:
https://doaj.org/article/acdcec591c4f4b49a2363032fe946ac9
Autor:
Chukiat Tantiwong, Joanne L. Dunster, Rachel Cavill, Michael G. Tomlinson, Christoph Wierling, Johan W. M. Heemskerk, Jonathan M. Gibbins
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Receptor diffusion plays an essential role in cellular signalling via the plasma membrane microenvironment and receptor interactions, but the regulation is not well understood. To aid in understanding of the key determinants of receptor diff
Externí odkaz:
https://doaj.org/article/2abb3eaafda6408294a30fc4910406b0
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-21 (2023)
Abstract Protein mutations, especially those which occur in the binding site, play an important role in inter-individual drug response and may alter binding affinity and thus impact the drug’s efficacy and side effects. Unfortunately, large-scale e
Externí odkaz:
https://doaj.org/article/0d68f218410c4d5b8444f0d9376717f4
Autor:
Joshua Harvey, Rick A. Reijnders, Rachel Cavill, Annelien Duits, Sebastian Köhler, Lars Eijssen, Bart P. F. Rutten, Gemma Shireby, Ali Torkamani, Byron Creese, Albert F. G. Leentjens, Katie Lunnon, Ehsan Pishva
Publikováno v:
npj Parkinson's Disease, Vol 8, Iss 1, Pp 1-11 (2022)
Abstract Cognitive impairment is a debilitating symptom in Parkinson’s disease (PD). We aimed to establish an accurate multivariate machine learning (ML) model to predict cognitive outcome in newly diagnosed PD cases from the Parkinson’s Progress
Externí odkaz:
https://doaj.org/article/7a6b56cc14f14f05bc1e79acbd2b4110
Publikováno v:
Journal of Cheminformatics, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract A key concept in drug design is how natural variants, especially the ones occurring in the binding site of drug targets, affect the inter-individual drug response and efficacy by altering binding affinity. These effects have been studied on
Externí odkaz:
https://doaj.org/article/930c97fb54754568a14ebe7213f2914d
Autor:
Shauna D O'Donovan, Rachel Cavill, Florian Wimmenauer, Alexander Lukas, Tobias Stumm, Evgueni Smirnov, Michael Lenz, Gokhan Ertaylan, Danyel G J Jennen, Natal A W van Riel, Kurt Driessens, Ralf L M Peeters, Theo M C M de Kok
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0292030 (2023)
The liver is the primary site for the metabolism and detoxification of many compounds, including pharmaceuticals. Consequently, it is also the primary location for many adverse reactions. As the liver is not readily accessible for sampling in humans;
Externí odkaz:
https://doaj.org/article/6585bbc2c6084525bdf1b8f9ae8698b8
Autor:
Jingnan Huang, Frauke Swieringa, Fiorella A. Solari, Isabella Provenzale, Luigi Grassi, Ilaria De Simone, Constance C. F. M. J. Baaten, Rachel Cavill, Albert Sickmann, Mattia Frontini, Johan W. M. Heemskerk
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Novel platelet and megakaryocyte transcriptome analysis allows prediction of the full or theoretical proteome of a representative human platelet. Here, we integrated the established platelet proteomes from six cohorts of healthy subjects, en
Externí odkaz:
https://doaj.org/article/98b564f1b944467ca88a30f85c123905
Autor:
Shauna D O'Donovan, Kurt Driessens, Daniel Lopatta, Florian Wimmenauer, Alexander Lukas, Jelmer Neeven, Tobias Stumm, Evgueni Smirnov, Michael Lenz, Gokhan Ertaylan, Danyel G J Jennen, Natal A W van Riel, Rachel Cavill, Ralf L M Peeters, Theo M C M de Kok
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0236392 (2020)
In clinical trials, animal and cell line models are often used to evaluate the potential toxic effects of a novel compound or candidate drug before progressing to human trials. However, relating the results of animal and in vitro model exposures to r
Externí odkaz:
https://doaj.org/article/a72b730386344772802bb761c9e4009c
Autor:
Johanna P. van Geffen, Sanne L.N. Brouns, Joana Batista, Harriet McKinney, Carly Kempster, Magdolna Nagy, Suthesh Sivapalaratnam, Constance C.F.M.J. Baaten, Nikki Bourry, Mattia Frontini, Kerstin Jurk, Manuela Krause, Daniele Pillitteri, Frauke Swieringa, Remco Verdoold, Rachel Cavill, Marijke J. E. Kuijpers, Willem H. Ouwehand, Kate Downes, Johan W.M. Heemskerk
Publikováno v:
Haematologica, Vol 104, Iss 6 (2019)
In combination with microspotting, whole-blood microfluidics can provide high-throughput information on multiple platelet functions in thrombus formation. Based on assessment of the inter- and intra-subject variability in parameters of microspot-base
Externí odkaz:
https://doaj.org/article/640d027bc958474f9702982d47c71f73