Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rachel‐Ann A. Garibsingh"'
Autor:
Rachel-Ann A. Garibsingh, Nicholas J. Otte, Elias Ndaru, Claire Colas, Christof Grewer, Jeff Holst, Avner Schlessinger
Publikováno v:
Frontiers in Chemistry, Vol 6 (2018)
The Alanine-Serine-Cysteine transporter (SLC1A5, ASCT2), is a neutral amino acid exchanger involved in the intracellular homeostasis of amino acids in peripheral tissues. Given its role in supplying glutamine to rapidly proliferating cancer cells in
Externí odkaz:
https://doaj.org/article/0bbeedd4a4074319bf72ac4836368ba1
Autor:
Elias Ndaru, Laura Zielewicz, Yueyue Shi, Keino Hutchinson, Rachel‐Ann A. Garibsingh, Avner Schlessinger, Christof Grewer
Publikováno v:
Journal of physical organic chemistry. 35(11)
The glutamine transporter ASCT2 is highly overexpressed in cancer cells. Block of glutamine uptake by ASCT2 is a potential strategy to inhibit growth of cancer cells. However, pharmacology of the ASCT2 binding site is not well established. In this wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30717a2d47b741d21565dc2e6e029f8f
https://pubmed.ncbi.nlm.nih.gov/36568026
https://pubmed.ncbi.nlm.nih.gov/36568026
Autor:
Roch-Philippe Charles, Dimitrios Fotiadis, Patrick D. Bosshart, Rachel-Ann A. Garibsingh, Avner Schlessinger
Publikováno v:
Trends in Biochemical Sciences. 46:28-40
The solute carrier 16 (SLC16) family represents a diverse group of membrane proteins mediating the transport of monocarboxylates across biological membranes. Family members show a variety of functional roles ranging from nutrient transport and intrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3498a54e4a95cba17e895a605455bb1d
https://doi.org/10.1016/j.tibs.2020.07.005
https://doi.org/10.1016/j.tibs.2020.07.005
Autor:
Massimiliano Bonomi, Cristina Paulino, Christof Grewer, Paul Zakrepine, Rachel Ann A. Garibsingh, Avner Schlessinger, Dirk Jan Slotboom, Elias Ndaru, Laura Zielewicz, Yueyue Shi, Alisa A. Garaeva
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (37), pp.e2104093118. ⟨10.1073/pnas.2104093118⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (37), pp.e2104093118. ⟨10.1073/pnas.2104093118⟩
Proceedings of the National Academy of Sciences of the United States of America, 118(37):e2104093118. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (37), pp.e2104093118. ⟨10.1073/pnas.2104093118⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (37), pp.e2104093118. ⟨10.1073/pnas.2104093118⟩
Proceedings of the National Academy of Sciences of the United States of America, 118(37):e2104093118. NATL ACAD SCIENCES
Significance The glutamine transporter ASCT2 is an emerging therapeutic target for various cancer types. Here, we use an integrated computational and experimental approach to develop unique ASCT2 inhibitors targeting a conformational state useful for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adcd7b1cfe4aa735aca7cff14f732ba3
https://hal.science/hal-03417486v2/document
https://hal.science/hal-03417486v2/document
Publikováno v:
Trends in Pharmacological Sciences. 40:790-800
There are over 420 human solute carrier (SLC) transporters from 65 families that are expressed ubiquitously in the body. The SLCs mediate the movement of ions, drugs, and metabolites across membranes and their dysfunction has been associated with a v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36fbb1674045a60c1d981d2ffd2bf6b
https://doi.org/10.1016/j.tips.2019.08.006
https://doi.org/10.1016/j.tips.2019.08.006
Autor:
Paul Zakrepine, Rachel-Ann A. Garibsingh, Jiali Wang, Christof Grewer, Avner Schlessinger, Evan Wallace, Yueyue Shi, Elias Ndaru
Publikováno v:
The Journal of General Physiology
ASCT2 is a transporter that exchanges neutral amino acids such as glutamine across the cell membrane, an essential process for rapidly growing cells, including cancerous ones. Ndaru et al. report the synthesis and characterization of a novel class of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::568679f0822338ead44f0f798229d3e1
https://doi.org/10.1085/jgp.201812276
https://doi.org/10.1085/jgp.201812276
Autor:
Christof Grewer, Cristina Paulino, Rachel-Ann A. Garibsingh, Alisa A. Garaeva, Avner Schlessinger, Elias Ndaru, Massimiliano Bonomi, Dirk Jan Slotboom
ASCT2 (SLC1A5) is a sodium-dependent neutral amino acid transporter that controls amino acid homeostasis in peripheral tissues. ASCT2 is upregulated in cancer, where it modulates intracellular glutamine levels, fueling cell proliferation. Nutrient de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9b859867016eb41a02e28f1086cceb0
https://doi.org/10.1101/2020.05.29.124305
https://doi.org/10.1101/2020.05.29.124305
Publikováno v:
Biochem J
Glutamine transport across cell membranes is performed by a variety of transporters, including the alanine serine cysteine transporter 2 (ASCT2). The substrate-binding site of ASCT2 was proposed to be specific for small amino acids with neutral side
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678b9ec442cafe0aff0604bf1a877454
https://pubmed.ncbi.nlm.nih.gov/32242892
https://pubmed.ncbi.nlm.nih.gov/32242892
Autor:
Rachel-Ann A. Garibsingh, Erica K. Benson, Sathish Kumar Mungamuri, Davide Esposito, E. Premkumar Reddy, Stuart A. Aaronson, Albino Troilo
Publikováno v:
Oncotarget
// Albino Troilo 1,* , Erica K. Benson 1,* , Davide Esposito 1 , Rachel-Ann A. Garibsingh 1 , E. Premkumar Reddy 1 , Sathish Kumar Mungamuri 1 and Stuart A. Aaronson 1 1 Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c43d704c4b6a6c1f38cb46584001f7
http://europepmc.org/articles/PMC5045355
http://europepmc.org/articles/PMC5045355