Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rachel, Pooley"'
Autor:
Francesco Iorio, Fiona M. Behan, Emanuel Gonçalves, Shriram G. Bhosle, Elisabeth Chen, Rebecca Shepherd, Charlotte Beaver, Rizwan Ansari, Rachel Pooley, Piers Wilkinson, Sarah Harper, Adam P. Butler, Euan A. Stronach, Julio Saez-Rodriguez, Kosuke Yusa, Mathew J. Garnett
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Background Genome editing by CRISPR-Cas9 technology allows large-scale screening of gene essentiality in cancer. A confounding factor when interpreting CRISPR-Cas9 screens is the high false-positive rate in detecting essential genes within c
Externí odkaz:
https://doaj.org/article/1bb1e9839ee048d0acfbc344b2b5b02a
Publikováno v:
Journal of Clinical Medicine Research. 14:425-431
Although neuraxial techniques such as caudal and epidural anesthesia were initially the predominant regional anesthetic technique used to provide postoperative analgesia in children, there has been a transition to the use of peripheral nerve blockade
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e4fa9120ee61c0a346cec82f1b8c88
https://doi.org/10.14740/jocmr4813
https://doi.org/10.14740/jocmr4813
Autor:
Michael Anderson, Matthew Bennett, Ruel Cedeno, Marta K. Dudek, Kristen Fichthorn, Aaron R. Finney, Ian Ford, Colin Freeman, Alan Hare, Connor Hewson, Adam Hill, Joonsoo Kim, Christine Kirschhock, Christian Kuttner, Fiona Meldrum, Sten O. Nilsson Lill, Rachel Pooley, Ivo B. Rietveld, Jeffrey Rimer, Kevin Roberts, Jutta Rogal, Matteo Salvalaglio, Jan Sefcik, Wenhao Sun, Damien Thompson, Jincheng Tong, Mollie Trueman, Peter Vekilov
Publikováno v:
Faraday Discussions. 235:383-405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce90f1065a9d86b9ff0195d325fcb503
https://doi.org/10.1039/d2fd90022j
https://doi.org/10.1039/d2fd90022j
Autor:
Livio Trusolino, David A. Jackson, Francesco Iorio, Dieudonne van der Meer, Gabriele Picco, Julio Saez-Rodriguez, Emanuel Gonçalves, Charlotte M. Beaver, Fiona M. Behan, Yanhua Rao, Sarah Harper, Mathew J. Garnett, Giorgia Migliardi, Marika Pinnelli, Euan A. Stronach, Rachel Pooley, Rebecca McRae, Francesco Sassi, Kosuke Yusa, Carolyn Buser-Doepner, Rita Santos, Piers Wilkinson, Rizwan Ansari, David J. Dow, Andrea Bertotti
Publikováno v:
Nature
Functional genomics approaches can overcome limitations—such as the lack of identification of robust targets and poor clinical efficacy—that hamper cancer drug development. Here we performed genome-scale CRISPR–Cas9 screens in 324 human cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03f6d7e8b782dcf7803152899bb75e8
https://doi.org/10.1038/s41586-019-1103-9
https://doi.org/10.1038/s41586-019-1103-9
Autor:
Fiona M, Behan, Francesco, Iorio, Gabriele, Picco, Emanuel, Gonçalves, Charlotte M, Beaver, Giorgia, Migliardi, Rita, Santos, Yanhua, Rao, Francesco, Sassi, Marika, Pinnelli, Rizwan, Ansari, Sarah, Harper, David Adam, Jackson, Rebecca, McRae, Rachel, Pooley, Piers, Wilkinson, Dieudonne, van der Meer, David, Dow, Carolyn, Buser-Doepner, Andrea, Bertotti, Livio, Trusolino, Euan A, Stronach, Julio, Saez-Rodriguez, Kosuke, Yusa, Mathew J, Garnett
Functional genomics approaches can overcome limitations-such as the lack of identification of robust targets and poor clinical efficacy-that hamper cancer drug development. Here we performed genome-scale CRISPR-Cas9 screens in 324 human cancer cell l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3e4160865bd30041e8ccfb533580ca27
http://hdl.handle.net/2318/1714058
http://hdl.handle.net/2318/1714058
Autor:
David J. Dow, Carolyn Buser-Doepner, Euan A. Stronach, Emanuel Gonçalves, Rachel Pooley, Mathew J. Garnett, Sarah Harper, Rebecca McRae, Piers Wilkinson, David A. Jackson, Charlotte M. Beaver, Kosuke Yusa, Yanhua Rao, Francesco Iorio, Gabriele Picco, Rizwan Ansari, Fiona M. Behan, Julio Saez-Rodriguez, Rita Santos
SummaryFunctional genomics approaches can overcome current limitations that hamper oncology drug development such as lack of robust target identification and clinical efficacy. Here we performed genome-scale CRISPR-Cas9 screens in 204 human cancer ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5dc8dfa7784cfc9ae07f20c623379d3
Autor:
Kosuke Yusa, Francesco Iorio, Piers Wilkinson, Mathew J. Garnett, Sarah Harper, Rachel Pooley, Rizwan Ansari, Charlotte M. Beaver, David A. Jackson, Fiona M. Behan
Publikováno v:
ESMO Open. 3:A149
Introduction The aim of this project was to perform genome-wide loss-of-function CRISPR-Cas9 screens across hundreds of genetically-annotated human cancer cell lines to identify synthetic-lethal interaction between cancer genomes and targeted gene de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66f390e834fdc8c2bcaebb81b94bac2a
https://doi.org/10.1136/esmoopen-2018-eacr25.357
https://doi.org/10.1136/esmoopen-2018-eacr25.357