Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Rachel, Ostroff"'
Autor:
Maik Pietzner, Eleanor Wheeler, Julia Carrasco-Zanini, Johannes Raffler, Nicola D. Kerrison, Erin Oerton, Victoria P. W. Auyeung, Jian’an Luan, Chris Finan, Juan P. Casas, Rachel Ostroff, Steve A. Williams, Gabi Kastenmüller, Markus Ralser, Eric R. Gamazon, Nicholas J. Wareham, Aroon D. Hingorani, Claudia Langenberg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Finding effective treatments for COVID-19 depends upon understanding genetic regulation of proteins involved in SARS-CoV-2 infection and host response. Here, the authors identify genetic variants linked to expression of such proteins, data which coul
Externí odkaz:
https://doaj.org/article/6b38e315ccef41ffb7a303ba54fecf8c
Autor:
Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clément, Jörn M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly, James Clark, Heather J. Cordell, Rebecca Darlay, Christopher P. Day, Tim Hardy, Yang-Lin Liu, Fiona Oakley, Jeremy Palmer, Rachel Queen, Kristy Wonders, Patrick M. Bossuyt, Adriaan G. Holleboom, Hadi Zafarmand, Yasaman Vali, Jenny Lee, Karine Clement, Raluca Pais, Detlef Schuppan, Michael Allison, Sergio Rodriguez Cuenca, Vanessa Pellegrinelli, Michele Vacca, Antonio Vidal-Puig, Tuulia Hyötyläinen, Aidan McGlinchey, Matej Orešič, Partho Sen, Jose Mato, Óscar Millet, Jean-Francois Dufour, Stephen Harrison, Stefan Neubauer, Michael Pavlides, Ferenc Mozes, Salma Akhtar, Rajarshi Banerjee, Matt Kelly, Elizabeth Shumbayawonda, Andrea Dennis, Charlotte Erpicum, Manuel Romero-Gomez, Rocío Gallego-Durán, Isabel Fernández, Morten Karsdal, Diana Leeming, Mette Juul Fisker, Elisabeth Erhardtsen, Daniel Rasmussen, Per Qvist, Antonia Sinisi, Estelle Sandt, Maria Manuela Tonini, Maurizio Parola, Chiara Rosso, Fabio Marra, Amalia Gastaldelli, Sven Francque, Stergios Kechagias, Hannele Yki-Järvinen, Kimmo Porthan, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Luca Valenti, Salvatore Petta, Luca Miele, Andreas Geier, Christian Trautwein, Paul Hockings, Phil Newsome, David Wenn, Cecília Maria Pereira Rodrigues, Rémy Hanf, Pierre Chaumat, Christian Rosenquist, Aldo Trylesinski, Pablo Ortiz, Kevin Duffin, Carla Yunis, Melissa Miller, Theresa Tuthill, Judith Ertle, Ramy Younes, Leigh Alexander, Rachel Ostroff, Mette Skalshøi Kjær, Lars Friis Mikkelsen, Clifford Brass, Lori Jennings, Maria-Magdalena Balp, Miljen Martic, Guido Hanauer, Sudha Shankar, Richard Torstenson, Céline Fournier, Richard Ehman, Michael Kalutkiewicz, Kay Pepin, Joel Myers, Diane Shevell, Gideon Ho, Henrik Landgren, Rob Myers, Lynda Doward, Diane Whalley, James Twiss
Publikováno v:
JHEP Reports, Vol 4, Iss 2, Pp 100409- (2022)
Background & Aims: Serum microRNA (miRNA) levels are known to change in non-alcoholic fatty liver disease (NAFLD) and may serve as useful biomarkers. This study aimed to profile miRNAs comprehensively at all NAFLD stages. Methods: We profiled 2,083 s
Externí odkaz:
https://doaj.org/article/bf7c90fd285b4e33a8d02523458d147c
Autor:
Joseph Yang, Edward N. Brody, Ashwin C. Murthy, Robert E. Mehler, Sophie J. Weiss, Robert K. DeLisle, Rachel Ostroff, Stephen A. Williams, Peter Ganz
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 15 (2020)
Background Chronic kidney disease (CKD) confers increased cardiovascular risk, not fully explained by traditional factors. Proteins regulate biological processes and inform the risk of diseases. Thus, in 938 patients with stable coronary heart diseas
Externí odkaz:
https://doaj.org/article/f83d4b28db5b4ae185992624b9f7d669
Autor:
Arun J. Sanyal, Stephen A. Williams, Joel E. Lavine, Brent A. Neuschwander-Tetri, Leigh Alexander, Rachel Ostroff, Hannah Biegel, Kris V. Kowdley, Naga Chalasani, Srinivasan Dasarathy, Anna Mae Diehl, Rohit Loomba, Bilal Hameed, Cynthia Behling, David E. Kleiner, Saul J. Karpen, Jessica Williams, Yi Jia, Katherine P. Yates, James Tonascia
Publikováno v:
Journal of hepatology, vol 78, iss 4
J Hepatol
J Hepatol
There is an unmet need for development of non-invasive tests for the diagnostic assessment and monitoring of nonalcoholic fatty liver disease (NAFLD).Using modified-aptamer proteomics, we assayed 5220 proteins in each of 2852 single serum samples fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b98d930021ee18e344ed6b8fc32118b5
https://escholarship.org/uc/item/0d9809np
https://escholarship.org/uc/item/0d9809np
Autor:
Maik Pietzner, Eleanor Wheeler, Julia Carrasco-Zanini, Johannes Raffler, Nicola D. Kerrison, Erin Oerton, Victoria P. W. Auyeung, Jian’an Luan, Chris Finan, Juan P. Casas, Rachel Ostroff, Steve A. Williams, Gabi Kastenmüller, Markus Ralser, Eric R. Gamazon, Nicholas J. Wareham, Aroon D. Hingorani, Claudia Langenberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21370-6
Externí odkaz:
https://doaj.org/article/397bb298c3a84338a2a39a389678856b
Autor:
Yasaman Vali, Jenny Lee, Jerome Boursier, Salvatore Petta, Kristy Wonders, Dina Tiniakos, Pierre Bedossa, Andreas Geier, Sven Francque, Mike Allison, Georgios Papatheodoridis, Helena Cortez-Pinto, Raluca Pais, Jean-Francois Dufour, Diana Julie Leeming, Stephen A Harrison, Yu Chen, Jeremy F Cobbold, Michael Pavlides, Adriaan G Holleboom, Hannele Yki-Jarvinen, Javier Crespo, Morten Karsdal, Rachel Ostroff, Mohammad Hadi Zafarmand, Richard Torstenson, Kevin Duffin, Carla Yunis, Clifford Brass, Mattias Ekstedt, Guruprasad P Aithal, Jörn M Schattenberg, Elisabetta Bugianesi, Manuel Romero-Gomez, Vlad Ratziu, Quentin M Anstee, Patrick M Bossuyt
Publikováno v:
lancet. Gastroenterology & hepatology. Elsevier Limited
Vali, Yasaman; Lee, Jenny; Boursier, Jerome; Petta, Salvatore; Wonders, Kristy; Tiniakos, Dina; Bedossa, Pierre; Geier, Andreas; Francque, Sven; Allison, Mike; Papatheodoridis, Georgios; Cortez-Pinto, Helena; Pais, Raluca; Dufour, Jean-Francois; Leeming, Diana Julie; Harrison, Stephen A; Chen, Yu; Cobbold, Jeremy F; Pavlides, Michael; Holleboom, Adriaan G; ... (2023). Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study. The lancet. Gastroenterology & hepatology, 8(8), pp. 714-725. Elsevier 10.1016/S2468-1253(23)00017-1
Vali, Yasaman; Lee, Jenny; Boursier, Jerome; Petta, Salvatore; Wonders, Kristy; Tiniakos, Dina; Bedossa, Pierre; Geier, Andreas; Francque, Sven; Allison, Mike; Papatheodoridis, Georgios; Cortez-Pinto, Helena; Pais, Raluca; Dufour, Jean-Francois; Leeming, Diana Julie; Harrison, Stephen A; Chen, Yu; Cobbold, Jeremy F; Pavlides, Michael; Holleboom, Adriaan G; ... (2023). Biomarkers for staging fibrosis and non-alcoholic steatohepatitis in non-alcoholic fatty liver disease (the LITMUS project): a comparative diagnostic accuracy study. The lancet. Gastroenterology & hepatology, 8(8), pp. 714-725. Elsevier 10.1016/S2468-1253(23)00017-1
BACKGROUND The reference standard for detecting non-alcoholic steatohepatitis (NASH) and staging fibrosis-liver biopsy-is invasive and resource intensive. Non-invasive biomarkers are urgently needed, but few studies have compared these biomarkers in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e5804b97ea21d329f8be39ff3820775
https://pure.amc.nl/en/publications/biomarkers-for-staging-fibrosis-and-nonalcoholic-steatohepatitis-in-nonalcoholic-fatty-liver-disease-the-litmus-project(ec377298-92db-4611-8b8e-8f9f2f3e8216).html
https://pure.amc.nl/en/publications/biomarkers-for-staging-fibrosis-and-nonalcoholic-steatohepatitis-in-nonalcoholic-fatty-liver-disease-the-litmus-project(ec377298-92db-4611-8b8e-8f9f2f3e8216).html
Autor:
John G. Edwards, Matthew Neilson, Davand Sharma, Fiona T. Thomson, Carol McCormick, Caroline Kelly, Euan J. Cameron, Seamus Grundy, Stephen R. L. Clark, Samantha Hinsley, David Breen, Angela Wright, Dipak Mukherjee, Crispin J. Miller, Rachel Ostroff, Alan Hart-Thomas, J Holme, Mohammed Munavvar, Ioannis Psallidas, Giles Cox, Holly Hall, Rakesh Panchal, Nick A Maskell, Rehan Naseer, Matthew Evison, Leigh Alexander, Laura Alexander, Mahendran Chetty, Alina Ionescu, S. Tsim, Elankumaran Paramasivam, Kevin G. Blyth, Ann Shaw, Douglas Grieve, Anthony J. Chalmers, C Daneshvar
Publikováno v:
Journal of Thoracic Oncology
Introduction:\ud Malignant pleural mesothelioma (MPM) is difficult to diagnose. An accurate blood biomarker could prompt specialist referral or be deployed in future screening. In earlier retrospective studies, SOMAscan proteomics (Somalogic, Boulder
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67306584ec865a096c53739cd9afb0c
https://doi.org/10.1016/j.jtho.2021.05.018
https://doi.org/10.1016/j.jtho.2021.05.018
Publikováno v:
Alzheimer's & Dementia. 18
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a13125a1f1d810ec80e6c6c42636b477
https://doi.org/10.1002/alz.068869
https://doi.org/10.1002/alz.068869
Autor:
Julia Carrasco-Zanini, Maik Pietzner, Joni V. Lindbohm, Eleanor Wheeler, Erin Oerton, Nicola Kerrison, Missy Simpson, Matthew Westacott, Dan Drolet, Mika Kivimaki, Rachel Ostroff, Stephen A. Williams, Nicholas J. Wareham, Claudia Langenberg
Publikováno v:
Nat Med
A new study combines large-scale proteomics and machine learning to identify proteins that can be used to identify individuals with isolated impaired glucose tolerance, who would otherwise only be detectable with oral glucose tolerance tests.The impl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c937d31f8f1d0a364efc6b0688d47287
https://europepmc.org/articles/PMC7614638/
https://europepmc.org/articles/PMC7614638/
Autor:
Stephen A. Williams, Rachel Ostroff, Michael A. Hinterberg, Josef Coresh, Christie M. Ballantyne, Kunihiro Matsushita, Christian E. Mueller, Joan Walter, Christian Jonasson, Rury R. Holman, Svati H. Shah, Naveed Sattar, Roy Taylor, Michael E. Lean, Shintaro Kato, Hiroaki Shimokawa, Yasuhiko Sakata, Kotaro Nochioka, Chirag R. Parikh, Steven G. Coca, Torbjørn Omland, Jessica Chadwick, David Astling, Yolanda Hagar, Natasha Kureshi, Kelsey Loupy, Clare Paterson, Jeremy Primus, Missy Simpson, Nelson P. Trujillo, Peter Ganz
Publikováno v:
Yearbook of Paediatric Endocrinology.
A reliable, individualized, and dynamic surrogate of cardiovascular risk, synoptic for key biologic mechanisms, could shorten the path for drug development, enhance drug cost-effectiveness and improve patient outcomes. We used highly multiplexed prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af50c296b3f5e925f23f621075af8a4
https://doi.org/10.1530/ey.19.14.9
https://doi.org/10.1530/ey.19.14.9