Výsledky vyhledávání - "Rachel, Milne"

Akademický článek

ResMAP—a saturation mutagenesis platform enabling parallel profiling of target-specific resistance-conferring mutations in Plasmodium

Autor: Richard J. Wall, Stuart A. MacGowan, Irene Hallyburton, Aisha J. Syed, Sowmya Ajay Castro, Gourav Dey, Rachel Milne, Stephen Patterson, Jody Phelan, Natalie Wiedemar, Susan Wyllie

Publikováno v: mBio, Vol 15, Iss 10 (2024)

ABSTRACT New and improved drugs are required for the treatment and ultimate eradication of malaria. The efficacy of front-line therapies is now threatened by emerging drug resistance; thus, new tools to support the development of drugs with a lower p

Externí odkaz: https://doaj.org/article/33debac63a434d15a1b26f35732aa229

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Akademický článek

Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Drug resistance to current antimalarials is rising and new drugs and targets are urgently needed. Here the authors identify Plasmodium falciparum acyl-CoA synthetase 10 as a new target whose inhibition leads to a decrease in triacylglycerols.

Externí odkaz: https://doaj.org/article/8ae40ec50bdc468aaa960a15e9ca87b3

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Akademický článek

Chemical pulldown combined with mass spectrometry to identify the molecular targets of antimalarials in cell-free lysates

Autor: Robert J. Smith, Rachel Milne, Victoriano Corpas Lopez, Natalie Wiedemar, Gourav Dey, Aisha J. Syed, Stephen Patterson, Susan Wyllie

Publikováno v: STAR Protocols, Vol 4, Iss 1, Pp 102002- (2023)

Summary: Here, we provide a protocol using chemical pulldown combined with mass spectrometry (LC-MS/MS) to identify drug targets in Plasmodium falciparum. This approach works upon the principle that a resin-bound inhibitor selectively binds its molec

Externí odkaz: https://doaj.org/article/1a30dcc35b09405bb943795be1123f19

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Antileishmanial Activities of (

Autor: Latifeh, Navidpour, Marta Lopes, Lima, Rachel, Milne, Susan, Wyllie, Narges, Hadj-Esfandiari, Muhammad Iqbal, Choudhary, Samreen, Khan, Sammer, Yousuf

Publikováno v: Antimicrob Agents Chemother

The antileishmanial activity of a series of (Z)-2-(heteroarylmethylene)-3(2H)-benzofuranone derivatives, possessing 5-nitroimidazole or 4-nitroimidazole moieties, was investigated against Leishmania major promastigotes and some analogues exhibited pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::351175d825cd1a2d350b08052bca4da8
https://pubmed.ncbi.nlm.nih.gov/36286539

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The beautiful and the damned: Depictions of Scottish childhoods in Small Deaths and Gasman

Autor: Rachel Milne

Publikováno v: Short Film Studies. 11:177-182

This article explores the function of poetic child realism in two of Lynne Ramsay’s short films, Small Deaths (1996) and Gasman (1998). Investigating the role of the orphaned child embedded in Scottish film culture, this article considers the ways

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::504934ca420203d129fd3637d2fa5a4d
https://doi.org/10.1386/sfs_00052_1

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Antileishmanial Activities of ( Z )-2-(Nitroimidazolylmethylene)-3( 2H )-Benzofuranones: Synthesis, In Vitro Assessment, and Bioactivation by NTR 1 and 2

Autor: Latifeh Navidpour, Marta Lopes Lima, Rachel Milne, Susan Wyllie, Narges Hadj-esfandiari, Muhammad Iqbal Choudhary, Samreen Khan, Sammer Yousuf

Publikováno v: Antimicrobial Agents and Chemotherapy. 66

The antileishmanial activity of a series of ( Z )-2-(heteroarylmethylene)-3(2 H )-benzofuranone derivatives, possessing 5-nitroimidazole or 4-nitroimidazole moieties, was investigated against Leishmania major promastigotes and some analogues exhibite

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::774e8caef935bb05cab281146b9ed2dd
https://doi.org/10.1128/aac.00583-22

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Chemical pulldown combined with mass spectrometry to identify the molecular targets of antimalarials in cell-free lysates

Autor: Robert J. Smith, Rachel Milne, Victoriano Corpas Lopez, Natalie Wiedemar, Gourav Dey, Aisha J. Syed, Stephen Patterson, Susan Wyllie

Publikováno v: STAR protocols. 4(1)

Here, we provide a protocol using chemical pulldown combined with mass spectrometry (LC-MS/MS) to identify drug targets in Plasmodium falciparum. This approach works upon the principle that a resin-bound inhibitor selectively binds its molecular targ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c97ba2b7daa0842eb6e1efca24b416
https://pubmed.ncbi.nlm.nih.gov/36609153

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High-Throughput Screening Platform To Identify Inhibitors of Protein Synthesis with Potential for the Treatment of Malaria

Autor: Fabio Tamaki, Fabio Fisher, Rachel Milne, Fernando Sánchez-Román Terán, Natalie Wiedemar, Karolina Wrobel, Darren Edwards, Hella Baumann, Ian H. Gilbert, Beatriz Baragana, Jake Baum, Susan Wyllie

Publikováno v: Antimicrobial agents and chemotherapy. 66(6)

Artemisinin-based combination therapies have been crucial in driving down the global burden of malaria, the world's largest parasitic killer. However, their efficacy is now threatened by the emergence of resistance in Southeast Asia and sub-Saharan A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08b9491e3f15954e2a8a01b4aa101ed
https://pubmed.ncbi.nlm.nih.gov/35647647

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