Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Rachel, Midgley"'
The treatment of cancer has undergone dramatic evolutions in the past two decades and the provision of holistic care by a multidisciplinary team of specialists is emerging as the cornerstone of recent improvements in outcome. Accompanying this multid
Autor:
Oliver M. Sieber, David Kerr, Rachel Midgley, Ian P.M. Tomlinson, Enric Domingo, Robert L. Strausberg, Dana Busam, Qi Zhao, Paul McMurrick, Adrian Polglase, Roger Berry, Peter W.G. Carne, Simon Knight, Adrian W. Pick, Peter M. Evans, Valery Usatoff, Benjamin N.J. Thomson, Katharine J. Drummond, Michael Christie, Robert N. Jorissen, Peter Gibbs, Jayesh Desai, Lara Lipton, Jeanne Tie
Purpose: Oncogene mutations contribute to colorectal cancer development. We searched for differences in oncogene mutation profiles between colorectal cancer metastases from different sites and evaluated these as markers for site of relapse.Experiment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9118783b7f4d2aee21297d4a85d69a97
https://doi.org/10.1158/1078-0432.c.6520413.v1
https://doi.org/10.1158/1078-0432.c.6520413.v1
Autor:
Oliver M. Sieber, David Kerr, Rachel Midgley, Ian P.M. Tomlinson, Enric Domingo, Robert L. Strausberg, Dana Busam, Qi Zhao, Paul McMurrick, Adrian Polglase, Roger Berry, Peter W.G. Carne, Simon Knight, Adrian W. Pick, Peter M. Evans, Valery Usatoff, Benjamin N.J. Thomson, Katharine J. Drummond, Michael Christie, Robert N. Jorissen, Peter Gibbs, Jayesh Desai, Lara Lipton, Jeanne Tie
Supplementary Tables S1-S4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d4726b73d659946e0105b66a11a7b47
https://doi.org/10.1158/1078-0432.22445193
https://doi.org/10.1158/1078-0432.22445193
Autor:
Chrystelle Colas, Carolina Bonilla, Yann Parc, Jérémie H. Lefevre, Katarzyna Hutnik, Elaine C. Johnstone, Abdelhamid Boumertit, Rachel Midgley, Susan Tonks, Tammy Day, David J. Kerr, Walter F. Bodmer, Bruce Winney
We examined the influence that rare variants and low-frequency polymorphisms in the cancer candidate gene CCND1 have on the development of multiple intestinal adenomas and the early onset of colorectal cancer. Individuals with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc0d754678fe124abe12ea1ef2b0becd
https://ora.ox.ac.uk/objects/uuid:a40f67e9-b411-4efd-9443-98486c7490af
https://ora.ox.ac.uk/objects/uuid:a40f67e9-b411-4efd-9443-98486c7490af
Autor:
Rachel Midgley, Sarah Briggs
Publikováno v:
Antiangiogenesis in Cancer Therapy. :69-89
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c6497b5362ef7cdaaa081cfce696ce6
https://doi.org/10.2217/ebo.13.635
https://doi.org/10.2217/ebo.13.635
Autor:
Malcolm G. Dunlop, Andrew D Beggs, Monica M. Bertagnolli, Luis G. Carvajal-Carmona, Harry Campbell, Rachel Midgley, Susan M. Farrington, Shirley Hodgson, Angela M. Jones, Albert Tenesa, Ian Tomlinson, Ann G. Zauber, Marion F Walker, David J. Kerr, Kimberley Howarth, Stephane Ballereau
Publikováno v:
Gut; Vol 61
ResearcherID
Gut, vol 61, iss 2
Gut
Jones, A M, Beggs, A D, Carvajal-Carmona, L, Farrington, S, Tenesa, A, Walker, M, Howarth, K, Ballereau, S, Hodgson, S V, Zauber, A, Bertagnolli, M, Midgley, R, Campbell, H, Kerr, D, Dunlop, M & Tomlinson, I P 2012, ' TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres ', Gut, vol. 61, no. 2, pp. 248-254 . https://doi.org/10.1136/gut.2011.239772
ResearcherID
Gut, vol 61, iss 2
Gut
Jones, A M, Beggs, A D, Carvajal-Carmona, L, Farrington, S, Tenesa, A, Walker, M, Howarth, K, Ballereau, S, Hodgson, S V, Zauber, A, Bertagnolli, M, Midgley, R, Campbell, H, Kerr, D, Dunlop, M & Tomlinson, I P 2012, ' TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres ', Gut, vol. 61, no. 2, pp. 248-254 . https://doi.org/10.1136/gut.2011.239772
BACKGROUND AND AIMS: Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to CRC.METHODS: In a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1b6570b16ae3d79c08c06a2de4fe4a
https://ora.ox.ac.uk/objects/uuid:c184e1b4-48f4-4ec8-9762-7871cd3c399a
https://ora.ox.ac.uk/objects/uuid:c184e1b4-48f4-4ec8-9762-7871cd3c399a
Autor:
P Mortimer, Rachel Midgley, J Brady, Ami Sabharwal, Mark R. Middleton, Geoffrey P. Margison, Pippa Corrie, C Palmer, Amanda J. Watson
2535 Background: The DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) contributes to cellular resistance to irinotecan (IR) and its metabolite SN-38. In human cancer cell lines MGMT expression correlates with SN-38 sensitivity, inacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eef6d3cb40a277bf0fc51b34fcb07f93
https://doi.org/10.1007/s00280-009-1225-0
https://doi.org/10.1007/s00280-009-1225-0
Autor:
Oliver M. Sieber, Christopher Holmes, Tarjei S. Hveem, Treena Cranston, Helen Lockstone, Elaine C. Johnstone, Ian Tomlinson, Peter L. Molloy, Zheng Zhou Xu, Marco Novelli, Hannah Pulker, David J. Kerr, Haitao Wang, Rachel Midgley, Daniel Norris Rosmarin, Håvard E. Danielsen, Brian R. Davidson, Rajarajan Ramamoorthy, Dahmane Oukrif, Enric Domingo, Michal Presz
Publikováno v:
The Journal of Pathology
Molecular classification of colorectal cancer (CRC) is currently based on microsatellite instability (MSI), KRAS or BRAF mutation and, occasionally, chromosomal instability (CIN). Whilst useful, these categories may not fully represent the underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c684b2778bcd888ca97ff0e287aa43b
https://doi.org/10.1002/path.4139
https://doi.org/10.1002/path.4139