Association between augmented renal clearance, antibiotic exposure and clinical outcome in critically ill septic patients receiving high doses of β-lactams administered by continuous infusion: a prospective observational study

Autor: Vincent Cottenceau, Cecile Foumenteze, Dominique Breilh, Rachel Legeron, Deborah Menu, Mélanie Lafitte, François Sztark, Laurent Petit, Noemie Sauvage, Quentin Hisz, Nicolas d'Houdain, Cédric Carrié

Publikováno v: International Journal of Antimicrobial Agents. 51:443-449

This study assessed whether augmented renal clearance (ARC) impacts negatively on antibiotic concentrations and clinical outcomes in patients treated by high-dose β-lactams administered continuously. Over a 9-month period, all critically ill patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b51a18d8fdf0455395acc53b04e6781
https://doi.org/10.1016/j.ijantimicag.2017.11.013

Higher than standard dosing regimen are needed to achieve optimal antibiotic exposure in critically ill patients with augmented renal clearance receiving piperacillin-tazobactam administered by continuous infusion

Autor: Matthieu Biais, D Breilh, Rachel Legeron, Mélanie Lafitte, Vincent Cottenceau, Julien Ollivier, F Xuereb, Cédric Carrié, Laurent Petit, François Sztark, Nicolas d'Houdain, Philippe Boyer

Publikováno v: Journal of critical care. 48

Purpose To determine whether augmented renal clearance (ARC) impacts negatively on piperacillin-tazobactam unbound concentrations in critically ill patients receiving 16 g/2 g/day administered continuously. Material and methods Fifty nine critically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d702e7b4ecf05ac1f331113c427512e4
https://pubmed.ncbi.nlm.nih.gov/30172963

A new reliable, transposable and cost-effective assay for absolute quantification of total plasmatic bevacizumab by LC-MS/MS in human plasma comparing two internal standard calibration approaches

Autor: Fabien Xuereb, Alain-Pierre Gadeau, Jean-Marie Schmitter, Jean-William Dupuy, Stéphane Claverol, Dominique Breilh, Rachel Legeron, Stéphane Chaignepain, Thierry Couffinhal, Sarah Djabarouti

Publikováno v: Journal of Chromatography B Biomedical Sciences and Applications
Journal of Chromatography B Biomedical Sciences and Applications, Elsevier, 2017, 1070, pp.43-53. ⟨10.1016/j.jchromb.2017.10.042⟩
Journal of Chromatography B Biomedical Sciences and Applications, 2017, 1070, pp.43-53. ⟨10.1016/j.jchromb.2017.10.042⟩

International audience; The quantification of monoclonal antibodies (mAbs) such as bevacizumab, a recombinant humanized immunoglobulin G1 (hIgG1), in biological fluids, is an essential prerequisite to any pharmacokinetic preclinical and clinical stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3e680c1ef4a522e195c088463a4a09
https://pubmed.ncbi.nlm.nih.gov/29111437

Chemical stability of azacitidine suspensions for injection after cold-chain reconstitution of powder and storage

Autor: Fabien Xuereb, Dominique Breilh, Rachel Legeron, Sarah Djabarouti, Marie-Claude Saux

Publikováno v: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 70(23)

Purpose The 72-hour chemical stability of refrigerated syringes of azacitidine suspension prepared via a cold-chain method is investigated. Methods Three 25-mg/mL azacitidine suspensions were prepared from different lots of powdered drug. The suspens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07e199d20c34b1a09744cbe284d3db3
https://pubmed.ncbi.nlm.nih.gov/24249764

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