Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Rachel, Giese"'
Autor:
Aditi Gupta, Sadna Budhu, Kelly Fitzgerald, Rachel Giese, Adam O. Michel, Aliya Holland, Luis Felipe Campesato, Jacques van Snick, Catherine Uyttenhove, Gerd Ritter, Jedd D. Wolchok, Taha Merghoub
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Gupta et al. demonstrate that targeting isoform-specific TGFβ leads to an increase in the anti-tumor response when compared to pan-TGFβ inhibition, due to enhanced CD8 T cell function. The authors also report that combining TGFβ inhibition with im
Externí odkaz:
https://doaj.org/article/ed988a10eff742c391e7da0374286113
Autor:
Taha Merghoub, Sadna Budhu, Luis Felipe Campesato, Aditi Gupta, Catherine Uyttenhove, Aliya Holland, Kelly Fitzgerald, Rachel Giese, Adam Michel, Jacques Van Snick, Gerd Ritter
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/b7686bae70e5419d9cb92be4956f038f
Autor:
Rachel, Giese
Publikováno v:
AnALize: Revista de studii feministe / Analize Journal of Gender and Feminist Studies. (12 (26)):9-15
Externí odkaz:
https://www.ceeol.com/search/article-detail?id=807866
Autor:
Sadna Budhu, Rachel Giese, Aditi Gupta, Kelly Fitzgerald, Roberta Zappasodi, Sara Schad, Daniel Hirschhorn, Luis Felipe Campesato, Olivier De Henau, Mathieu Gigoux, Cailian Liu, Gregory Mazo, Liang Deng, Christopher A. Barker, Jedd D. Wolchok, Taha Merghoub
Publikováno v:
Cell Reports, Vol 34, Iss 2, Pp 108620- (2021)
Summary: Phosphatidylserine (PS) is exposed on the surface of apoptotic cells and is known to promote immunosuppressive signals in the tumor microenvironment (TME). Antibodies that block PS interaction with its receptors have been shown to repolarize
Externí odkaz:
https://doaj.org/article/28347c74347b431ca45e2e2af07fc73b
Autor:
Taha Merghoub, Aditi Gupta, Gerd Ritter, Rachel Giese, Kelly Fitzgerald, Luis Felipe Campesato, Jacques Van Snick, Sadna Budhu, Jedd D. Wolchok, Catherine Uyttenhove, Adam O. Michel, Aliya Holland
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
TGFβ is a potential target in cancer treatment due to its dual role in tumorigenesis and homeostasis. However, the expression of TGFβ and its inhibition within the tumor microenvironment has mainly been investigated in stroma-heavy tumors. Using B1
Autor:
Weiyi Wang, Ning Yang, Liang Deng, Taha Merghoub, Shuaitong Liu, Rachel Giese, Jedd D. Wolchok, Peihong Dai, Yi Wang
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 9 (2021)
BackgroundViral-based immunotherapy can overcome resistance to immune checkpoint blockade (ICB) and fill the unmet needs of many patients with cancer. Oncolytic viruses (OVs) are defined as engineered or naturally occurring viruses that selectively r
Autor:
David Redmond, Vinod P. Balachandran, Luis Felipe Campesato, Sean Houghton, Marinela Capanu, Taha Merghoub, Roberta Zappasodi, Rachel Giese, Aditi Gupta, Billel Gasmi, Robert M. Samstein, Jedd D. Wolchok, Katherine S. Panageas, Sadna Budhu, Nathan Suek, Chirag Krishna, Michael O. Schneider, John Alec Moral, Danny N. Khalil, Daniel Hirschhorn, James J. Harding
Publikováno v:
Journal of Clinical Investigation. 129:3435-3447
Irreversible T cell exhaustion limits the efficacy of programmed cell death 1 (PD-1) blockade. We observed that dual CD40-TLR4 stimulation within a single tumor restored PD-1 sensitivity and that this regimen triggered a systemic tumor-specific CD8(+
Autor:
Luc G. T. Morris, Jiyuan Hu, Jocelyn C. Migliacci, Yuhan Hao, Rachel Giese, Dervla Kelly, Huilin Li, Matthew Rosenthal, Zhiheng Pei, Carlos W. Nossa, Stuart M. Brown, Ian Ganly, Wenzhi Tseng, Liying Yang
Publikováno v:
International Journal of Cancer. 145:775-784
Over the past decade, there has been a change in the epidemiology of oral cavity squamous cell cancer (OC-SCC). Many new cases of OC-SCC lack the recognized risk factors of smoking, alcohol and human papilloma virus. The aim of this study was to dete
Autor:
Catherine Uyttenhove, Gerd Ritter, Taha Merghoub, Jacques Van Snick, Aditi Gupta, Luis Felipe Campesato, Adam O. Michel, Jedd D. Wolchok, Rachel Giese, Aliya Holland, Sadna Budhu, Kelly Fitzgerald
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundTGFβ is a potential target in cancer treatment due to its dual role in tumorigenesis and homeostasis. There are three isoforms of TGFβ (TGFβ1, TGFβ2 and TGFβ3), which are secreted by immune and non-immune cells as an inactive latent co
Autor:
Taha Merghoub, Mathieu Gigoux, Luis Felipe Campesato, Roberta Zappasodi, Daniel Hirschhorn-Cymerman, Rachel Giese, Jedd D. Wolchok, Sadna Budhu, Cailian Liu, Aditi Gupta, Christopher A. Barker, Sara Schad, Olivier De Henau
Publikováno v:
SSRN Electronic Journal.
Phosphatidylserine (PS) is a phospholipid that is exposed on surface of apoptotic cells and has been shown to promote immunosuppressive signals in the tumor microenvironment (TME). Antibodies that block PS interaction with its receptors have been sho