Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Rachana Ohri"'
Autor:
Kimberly K. Kajihara, Homer Pantua, Hilda Hernandez-Barry, Meredith Hazen, Kiran Deshmukh, Nancy Chiang, Rachana Ohri, Erick R. Castellanos, Lynn Martin, Marissa L. Matsumoto, Jian Payandeh, Kelly M. Storek, Kellen Schneider, Peter A. Smith, Michael F. T. Koehler, Siao Ping Tsai, Richard Vandlen, Kelly M. Loyet, Gerald Nakamura, Thomas Pillow, Dhaya Seshasayee, Sharookh B. Kapadia, Wouter L. W. Hazenbos
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
Antibiotic treatment of life-threatening P. aeruginosain vitroP. aeruginosa
Externí odkaz:
https://doaj.org/article/55553da6bf96462684a50c1126fff190
Autor:
Jagath R. Junutula, Paul Polakis, Richard H. Scheller, Mark S. Dennis, Deepak Sampath, Jo-Anne Hongo, Helga Raab, Katherine R. Kozak, Aimee Fourie-O'Donohue, Ron Firestein, Robert Piskol, Eric Cheng, Mary Ann T. Go, Kirsten A. Poon, Fiona Zhong, Rachana Ohri, Coenraad Kuijl, Dongwei Li, Melissa M. Schutten, Meredith Hazen, Yvonne Chen, Lisa M. Crocker, Sunil Bhakta
Luminal A (hormone receptor-positive) breast cancer constitutes 70% of total breast cancer patients. In an attempt to develop a targeted therapeutic for this cancer indication, we have identified and characterized Glial cell line–Derived Neurotroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ebbf88322d045b6d0c4b08c2c22021d
https://doi.org/10.1158/1535-7163.c.6537960.v1
https://doi.org/10.1158/1535-7163.c.6537960.v1
Autor:
Jagath R. Junutula, John A. Flygare, Andrew G. Polson, Paul Polakis, Susan Spencer, Katherine K. Kozak, Janet Gunzner-Toste, Jinhua Chen, Fan Fang, Philip W. Howard, Stephen J. Gregson, Luke Masterson, Donglu Zhang, Amrita V. Kamath, Douglas D. Leipold, Keyang Xu, Carl Ng, Luna Liu, Jintang He, Sharon Yee, Jeffrey Lau, Mary Ann T. Go, Geoffrey Del Rosario, Fiona Zhong, Willy Solis, Kirsten Achilles Poon, Jack Sadowsky, Rachana Ohri, Shang-Fan Yu, Melissa Schutten, Thomas H. Pillow
Supplementary Figures S1-S5, Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bd04853a3b7478b1a76289e951f293
https://doi.org/10.1158/1535-7163.22503312.v1
https://doi.org/10.1158/1535-7163.22503312.v1
Autor:
Jagath R. Junutula, Paul Polakis, Richard H. Scheller, Mark S. Dennis, Deepak Sampath, Jo-Anne Hongo, Helga Raab, Katherine R. Kozak, Aimee Fourie-O'Donohue, Ron Firestein, Robert Piskol, Eric Cheng, Mary Ann T. Go, Kirsten A. Poon, Fiona Zhong, Rachana Ohri, Coenraad Kuijl, Dongwei Li, Melissa M. Schutten, Meredith Hazen, Yvonne Chen, Lisa M. Crocker, Sunil Bhakta
Figure S1. Validation of anti-GFRA1 antibodies (R&D systems and GNE-8H6) for the use of Immunohistochemistry (IHC) analysis; Figure S2. ELISA analyses to test binding specificity of anti-GFRA1 antibodies to GFRA1 (A) and GFRA2 (B) extra cellular doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100a6557ca8c0f2a229a1ced8e41d71e
https://doi.org/10.1158/1535-7163.22505118
https://doi.org/10.1158/1535-7163.22505118
Autor:
Nicholas J. Agard, Gu Zhang, John Ridgeway, Danielle M. Dicara, Phillip Y. Chu, Rachana Ohri, Sarah Sanowar, Jean-Michel Vernes, Hannah Chi, Jiameng Zhang, Emily Holz, Maciej Paluch, Guannan He, Yingjia Benson, Jianhuan Zhang, Pamela Chan, Nga Tang, Prachi Javale, Blair Wilson, Kathy Barrett, Rebecca K. Rowntree, Julie Hang, Y. Gloria Meng, Phil Hass, Germaine Fuh, Robert Piskol, Vladimir Bantseev, Kelly M. Loyet, John C. Tran, Cong Wu, Vahan B. Indjeian, Vittal Shivva, Minhong Yan
Publikováno v:
Translational vision sciencetechnology. 11(10)
Diabetic macular edema (DME) is the leading cause of vision loss and blindness among working-age adults. Although current intravitreal anti-vascular endothelial growth factor (VEGF) therapies improve vision for many patients with DME, approximately h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de973b297d39ff4f6a06b6bb5da9129
https://pubmed.ncbi.nlm.nih.gov/36255358
https://pubmed.ncbi.nlm.nih.gov/36255358
Autor:
Breanna S. Vollmar, Mingjian Fei, Wei-Ching Liang, Daniel D. Bravo, Joy Wang, Lanlan Yu, Nick Corr, Gu Zhang, Erin McNamara, Shabkhaiz Masih, Elin Chee, Gawon Shin, Rachana Ohri, Douglas D. Leipold, Cong Wu, Edward Dere, Jianyong Wang, Haochu Huang, Yan Wu, Minhong Yan
Publikováno v:
Bioconjugate chemistry. 33(10)
Here, we explore whether PEGylation of antibodies can modulate their biodistribution to the eye, an organ once thought to be immune privileged but has recently been shown to be accessible to IV-administered large molecules, such as antibodies. We cho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa651a8d252b4195b5e0c6a4232b6c8
https://pubmed.ncbi.nlm.nih.gov/36153839
https://pubmed.ncbi.nlm.nih.gov/36153839
Autor:
Peter S. Dragovich, Sheila Ulufatu, John S. Wai, James Lee, Reginald Delarosa, Carl Ng, Zijin Xu, Chunjiao Chen, Shang-Fan Yu, S. Cyrus Khojasteh, Gail Lewis Phillips, Rebecca K. Rowntree, Keyang Xu, Aimee Fourie-O'Donohue, Zhonghua Pei, Isabel Figueroa, Liling Liu, Josefa dela Cruz-Chuh, Jiawei Lu, Jun Guo, Weiwei Jin, Jing Wang, Jinhua Chen, Eva Lin, Nicola J. Stagg, David Stokoe, Scott E. Martin, Trung Nguyen, Donglu Zhang, Hui Yao, Guangmin Li, Rachana Ohri, Thomas H. Pillow, Katherine R. Kozak, Brandon Latifi, Yuzhong Deng, Vishal Verma
Publikováno v:
Molecular Pharmaceutics. 15:3979-3996
A number of cytotoxic pyrrolobenzodiazepine (PBD) monomers containing various disulfide-based prodrugs were evaluated for their ability to undergo activation (disulfide cleavage) in vitro in the presence of either glutathione (GSH) or cysteine (Cys).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137e6f9931e607d2a0302bf2150b678d
https://doi.org/10.1021/acs.molpharmaceut.8b00431
https://doi.org/10.1021/acs.molpharmaceut.8b00431
Autor:
Katherine R. Kozak, Siao Ping Tsai, Doug Leipold, Luke Masterson, Hui Yao, Stefan Steinbacher, Jim Nonomiya, Keyang Xu, Helga Raab, Vishal Verma, Binqing Wei, Jeff Lau, Tao Wang, Janet Gunzner-Toste, Shang-Fan Yu, John A. Flygare, Thomas H. Pillow, Leanna Staben, John S. Wai, Zijin Xu, Brian Safina, Gail Dianne Phillips, Philip Howard, Jing Wang, Dian Su, Josefa Chuh, Jinhua Chen, Guiling Zhao, Guangmin Li, Rachana Ohri, Yichin Liu, Amrita V. Kamath, Charles Eigenbrot
Publikováno v:
Journal of Medicinal Chemistry. 61:989-1000
Antibody-drug conjugates (ADCs) have become an important therapeutic modality for oncology, with three approved by the FDA and over 60 others in clinical trials. Despite the progress, improvements in ADC therapeutic index are desired. Peptide-based A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec0f3685ed5ba96d277235ba33db5f5
https://doi.org/10.1021/acs.jmedchem.7b01430
https://doi.org/10.1021/acs.jmedchem.7b01430
Autor:
Binqing Wei, Janet Gunzner-Toste, Guangmin Li, Helga Raab, Susan D. Spencer, Gail Lewis Phillips, Shang-Fan Yu, Katherine R. Kozak, Rachana Ohri, Jeffrey Lau, Philip Howard, Andrew Polson, Brian Safina, Luke Masterson, John A. Flygare, Thomas H. Pillow, Martine Darwish, Stephen J. Gregson, Gyoung-Dong Kang, Josefa dela Cruz-Chuh
Publikováno v:
Journal of Medicinal Chemistry. 60:9490-9507
Three rationally designed pyrrolobenzodiazepine (PBD) drug-linkers have been synthesized via intermediate 19 for use in antibody–drug conjugates (ADCs). They lack a cleavable trigger in the linker and consist of a maleimide for cysteine antibody co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a180d2e49398f22d60da17ee0112defd
https://doi.org/10.1021/acs.jmedchem.7b00736
https://doi.org/10.1021/acs.jmedchem.7b00736
Autor:
Jianhui Zhou, Jintang He, Breanna S. Vollmar, Shang-Fan Yu, Hans Erickson, Sharon Yee, Greg A. Lazar, Binqing Wei, Aimee Fourie-O'Donohue, Genee Lee, Amrita V. Kamath, Douglas D. Leipold, Rachana Ohri, Guangmin Li, Gail Lewis Phillips, Ely Cosino, Keyang Xu, Katherine R. Kozak
Publikováno v:
Bioconjugate Chemistry. 28:2538-2548
The incorporation of cysteines into antibodies by mutagenesis allows for the direct conjugation of small molecules to specific sites on the antibody via disulfide bonds. The stability of the disulfide bond linkage between the small molecule and the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a2136e028db58ed736a2814624d0b95
https://doi.org/10.1021/acs.bioconjchem.7b00365
https://doi.org/10.1021/acs.bioconjchem.7b00365