Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Rachael S. Allen"'
Autor:
Rachael S. Allen, Cara T. Khayat, Andrew J. Feola, Alice S. Win, Allison R. Grubman, Kyle C. Chesler, Li He, Jendayi A. Dixon, Timothy S. Kern, P. Michael Iuvone, Peter M. Thule, Machelle T. Pardue
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
PurposeLimited research exists on the time course of long-term retinal and cerebral deficits in diabetic rodents. Previously, we examined short term (4–8 weeks) deficits in the Goto-Kakizaki (GK) rat model of Type II diabetes. Here, we investigated
Externí odkaz:
https://doaj.org/article/345e783e9a644d19bafaf6be9b7ae790
Autor:
Lauren Hutson, Amber Douglass, Anayesha Singh, C. Ross Ethier, Kyle Chesler, Machelle T. Pardue, Kaavya Gudapati, Lara A. Skelton, Katie L. Bales, Rachael S Allen, Steven J. Fliesler, Matthew M. Harper, Sriganesh Ramachandra Rao, Cara Motz, Andrew Feola, Lidia Cardelle
Publikováno v:
Vision Res
Blast-induced traumatic brain injury is the signature injury of modern military conflicts. To more fully understand the effects of blast exposure, we placed rats in different holder configurations, exposed them to blast overpressure, and assessed the
Autor:
Andrew Feola, Rachael S Allen, Machelle T. Pardue, Cara Motz, Kyle Chesler, Harrison Vo, Amber Douglass
Publikováno v:
Translational Vision Science & Technology
Purpose L-DOPA treatment initiated at the start of hyperglycemia preserves retinal and visual function in diabetic rats. Here, we investigated a more clinically relevant treatment strategy in which retinal and visual dysfunction designated the beginn
Autor:
Dan C. Li, Rachael S Allen, Paul S. García, Amy Ottensmeyer, Austin N. Slone, Machelle T. Pardue, Christopher G. Sinon
Publikováno v:
Neurosci Lett
Diabetes has been demonstrated to be one of the strongest predictors of risk for postoperative delirium and functional decline in older patients undergoing surgery. Exercise is often prescribed as a treatment for diabetic patients and regular physica
Autor:
Rachael S Allen, Amber J. Douglass, Machelle T. Pardue, Anayesha Singh, Danielle Clarkson-Townsend, Ivie N. Uwaifo
Publikováno v:
Exp Eye Res
High fat diets (HFD) have been utilized in rodent models of visual disease for over 50 years to model the effects of lipids, metabolic dysfunction, and diet-induced obesity on vision and ocular health. HFD treatment can recapitulate the pathologies o
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Publikováno v:
J Vis Exp
Spectral-domain optical coherence tomography (SD-OCT) is useful for visualizing retinal and ocular structures in vivo. In research, SD-OCT is a valuable tool to evaluate and characterize changes in a variety of retinal and ocular disease and injury m
Autor:
Lara A. Skelton, Andrew Feola, Steven J. Fliesler, Kyle Chesler, Rachael S Allen, Machelle T. Pardue, Sriganesh Ramachandra Rao, Cara Motz, Raza Haider
Publikováno v:
Journal of Neurotrauma. 35:2104-2116
Acoustic blast overpressure (ABO) injury in military personnel and civilians is often accompanied by delayed visual deficits. However, most animal model studies dealing with blast-induced visual defects have focused on short-term (≤1 month) changes
Autor:
Rachael S Allen, Machelle T. Pardue
Publikováno v:
Progress in Retinal and Eye Research. 65:50-76
Diseases that affect the eye, including photoreceptor degeneration, diabetic retinopathy, and glaucoma, affect 11.8 million people in the US, resulting in vision loss and blindness. Loss of sight affects patient quality of life and puts an economic b
Autor:
Li Gan, Jude P.J. Savarraj, Steven J. Fliesler, James D. Reynolds, Jonathan S. Stamler, Min-Kyoo Shin, Sarah Barker, Machelle T. Pardue, Francisco Ortiz, Tara E. Tracy, Rachael S Allen, Feixiong Cheng, Pengyue Zhang, Kathryn Franke, H. Alex Choi, Jessica A. Kilgore, Victoria C. Whitehair, Mukesh K. Jain, Lara A. Skelton, Sriganesh Ramachandra Rao, Matasha Dhar, Divya Seth, Cara Motz, Chao Wang, Louise D. McCullough, Lang Li, Andrew A. Pieper, Chien-Wei Chiang, Maria F. Noterman, Ryan S. Kitagawa, Kalyani Chaubey, Daniel J. Liebl, Emiko Miller, Edwin Vázquez-Rosa, Hilda Ahnstedt, Glenda L. Torres, Noelle S. Williams, Coral J. Cintrón-Pérez, Yeojung Koh, Yuan Hou, Allison Kraus, Tamar Gefen, Margaret E. Flanagan
Publikováno v:
Cell
Traumatic brain injury (TBI) is the largest non-genetic, non-aging related risk factor for Alzheimer's disease (AD). We report here that TBI induces tau acetylation (ac-tau) at sites acetylated also in human AD brain. This is mediated by S-nitrosylat
Autor:
Yuliya Oumarbaeva, Paul H. Choi, Machelle T. Pardue, Donald G. Stein, Iqbal Sayeed, Katherine C. Morrison, Rachael S Allen
Publikováno v:
Restorative Neurology and Neuroscience. 34:947-963
Background/objective To determine whether inflammation increases in retina as it does in brain following middle cerebral artery occlusion (MCAO), and whether the neurosteroid progesterone, shown to have protective effects in both retina and brain aft