Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rachael Profit"'
Applying the Good Publication Practice 2022 Guidelines in the Asia-Pacific Region: A Practical Guide
Autor:
Blair Hesp, Katsuhisa Arai, Namita Bose, Rachael Profit, Malvika Katariya, Jonathan Lee, Ronnie Lin, Magdalene Chu, Andrew Sakko, Hazel Fernandez
Objective: The Asia-Pacific region (APAC) represents a unique environment for the publication of biomedical research, particularly industry-funded research. Awareness and adoption of international guidelines on ethical publication practices continues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68255ea1e8e4004d7abba42d2c8f20e0
https://doi.org/10.20944/preprints202304.0092.v1
https://doi.org/10.20944/preprints202304.0092.v1
Publikováno v:
International Journal of Digital Health. 2:6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9db6941713fdbbe56fbf649f1c30764
https://doi.org/10.29337/ijdh.46
https://doi.org/10.29337/ijdh.46
Autor:
Catherine Ritchie, Lucy Barker, Matthew Bm Thomas, Jodie Manini, Elisabeth Willard, Jennifer Willis, Zarin Brown, Edward Charles Hall, Gareth Williams, Ryan West, Steven J. Charlton, David Andrew Sandham, Lyndon Nigel Brown, Simon J. Watson, Janet Maas, Devnandan Chatterjee, David A. Sykes, Nicholas Duggan, Katharine L. Turner, Gerald Dubois, David C. Budd, Bindi Sohal, Rowan Stringer, Rachael Profit, Darren Riddy, Duncan Shaw, Julia Hatto, Brian Cox
Further optimization of an initial DP2 receptor antagonist clinical candidate NVP-QAV680 led to the discovery of a follow-up molecule 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid (compound 11,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65a3f67567222f76078480d2373e99e
https://europepmc.org/articles/PMC5430394/
https://europepmc.org/articles/PMC5430394/
Autor:
Brian Cox, David C. Budd, Anna King, Gareth Williams, Nicholas Duggan, Rowan Stringer, Marcus Furegati, Alfred Schmidt, Josef G. Meingassner, Kamlesh Bala, Brian Everatt, Katharine L. Turner, Jennifer Simmons, Cerys Docx, Catherine Leblanc, Gerald Dubois, Frank Kalthoff, Caroline Wilson, Lucy Barker, Karen England, Nicola Arnold, John Westwick, Edward Charles Hall, Bindi Sohal, Jennifer Willis, Heinrich Aschauer, David Andrew Sandham, Rachael Profit, Zarin Brown, Lyndon Nigel Brown, Simon J. Watson, Jodie Manini, Christoph Walker, Matthew Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:6582-6591
Optimization of a 7-azaindole-3-acetic acid CRTh2 receptor antagonist chemotype derived from high throughput screening furnished a highly selective compound NVP-QAV680 with low nM functional potency for inhibition of CRTh2 driven human eosinophil and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc63a5fbb90947c1f906a4739b943b4
https://doi.org/10.1016/j.bmc.2013.08.025
https://doi.org/10.1016/j.bmc.2013.08.025
Autor:
Justine M. Whitworth, Alicia J. Taylor, Sophie Caroline Williams, Alan Findlay Haughan, Philip J. Gilbert, Duncan R. Hannah, George M. Buckley, Natasha Davies, Rachael Profit, William R. Pitt, Hazel Joan Dyke, Caroline A. Hunt, Marianna D. Richard, Nicholas C. Ray, Andrew Sharpe
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:751-754
The development of a series of novel quinazolinethiones and quinazolinediones as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis, in vitro inhibitory values for IMPDH II and in vitro inhibitory value for PBMC pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836874af7b31b9fc5782f3b758df37a8
https://doi.org/10.1016/j.bmcl.2004.11.015
https://doi.org/10.1016/j.bmcl.2004.11.015
Autor:
Jennifer Willis, Devnandan Chatterjee, Elisabeth Willard, Gareth Williams, Zarin Brown, Duncan Shaw, Ryan West, Edward Charles Hall, David Andrew Sandham, Bindi Sohal, Julia Hatto, Steven J. Charlton, Lucy Barker, Gerald Dubois, Janet Maas, Jodie Manini, Rowan Stringer, Nicholas Duggan, Catherine Ritchie, David C. Budd, Katharine L. Turner, Brian Cox, Catherine Leblanc, Lyndon Nigel Brown, Simon J. Watson, David A. Sykes, Matthew Thomas, Darren Riddy, Rachael Profit
Publikováno v:
ACS Medicinal Chemistry Letters. 8:987-987
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::938165c3ed79370061b1dfa60d8a65e1
https://doi.org/10.1021/acsmedchemlett.7b00353
https://doi.org/10.1021/acsmedchemlett.7b00353
Autor:
Jodie Manini, Claire Adcock, Alfred Schmidt, Zarin Brown, Robin Alec Fairhurst, Rachael Profit, John Reilly, David C. Budd, Caroline Wilson, Simon J. Watson, Brian Cox, Kamlesh Bala, Jennifer Willis, Lucy Barker, Markus Furegati, David Andrew Sandham, Katharine L. Turner, Rowan Stringer, Catherine Leblanc, Gareth Williams, Gerald Dubois
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(16)
High throughput screening identified a 7-azaindole-3-acetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a highly selective compound with good functional potency for inhibition of human eosinophil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662232891c4a20f4a3460f90d84eb7a6
https://pubmed.ncbi.nlm.nih.gov/19592244
https://pubmed.ncbi.nlm.nih.gov/19592244
Autor:
David C. Budd, David Bryan Harrison, Christopher Walker, Lucy Barker, Morris Tweed, Brian Everatt, Louise Bidlake, Rowan Stringer, Clive Aldcroft, Gurdip Bhalay, Catherine Leblanc, Emma Michelle Campbell, Urs Baettig, Simon J. Watson, Rachael Profit, Jennifer Willis, Gareth Williams, David Beer, Katharine L. Turner, Steven Whitebread, Zarin Brown, David Andrew Sandham, Gerald Dubois, Jodie Manini, Katy S Thompson, Brian Cox, Caroline Wilson
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(15)
High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6368f8bff73f2b501c96315902c5c8fa
https://pubmed.ncbi.nlm.nih.gov/17531480
https://pubmed.ncbi.nlm.nih.gov/17531480