Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rachael Parks"'
Autor:
Maria L. Knudsen, Parul Agrawal, Anna MacCamy, K. Rachael Parks, Matthew D. Gray, Brittany N. Takushi, Arineh Khechaduri, Kelsey R. Salladay, Rhea N. Coler, Celia C. LaBranche, David Montefiori, Leonidas Stamatatos
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105473- (2022)
Summary: Once naive B cells expressing germline VRC01-class B cell receptors become activated by germline-targeting immunogens, they enter germinal centers and undergo affinity maturation. Booster immunizations with heterologous Envs are required for
Externí odkaz:
https://doaj.org/article/2a64a437ba714d9bb9830002de24fd76
Autor:
K. Rachael Parks, Anna J. MacCamy, Josephine Trichka, Matthew Gray, Connor Weidle, Andrew J. Borst, Arineh Khechaduri, Brittany Takushi, Parul Agrawal, Javier Guenaga, Richard T. Wyatt, Rhea Coler, Michael Seaman, Celia LaBranche, David C. Montefiori, David Veesler, Marie Pancera, Andrew McGuire, Leonidas Stamatatos
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 3060-3072.e7 (2019)
Summary: Broadly HIV-1 neutralizing VRC01 class antibodies target the CD4-binding site of Env. They are derived from VH1-2∗02 antibody heavy chains paired with rare light chains expressing 5-amino acid-long CDRL3s. They have been isolated from infe
Externí odkaz:
https://doaj.org/article/186a0f36c95d41e39e24afbc11ee4f79
Autor:
Nirasha Ramchurren, Rachael Parks, Laura Islas, Steven Fling, Michael Khodadoust, Evan Newell, David Glass
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Josephine J Trichka, Celia C. LaBranche, Richard T. Wyatt, Michael S. Seaman, David C. Montefiori, K. Rachael Parks, Javier Guenaga, Andrew T. McGuire, Matthew D. Gray, Marie Pancera, Anna J. MacCamy, Connor Weidle, Rhea N. Coler, Andrew J. Borst, Brittany Takushi, Arineh Khechaduri, Leonidas Stamatatos, David Veesler, Parul Agrawal
Publikováno v:
Cell Reports, Vol 29, Iss 10, Pp 3060-3072.e7 (2019)
Cell reports
Cell reports
SUMMARY Broadly HIV-1 neutralizing VRC01 class antibodies target the CD4-binding site of Env. They are derived from VH1–2*02 antibody heavy chains paired with rare light chains expressing 5-amino acid-long CDRL3s. They have been isolated from infec
Autor:
Jarrod S. Johnson, Fred D. Mast, Heather S. Kain, Rechel Geiger, Kamalakannan Vijayan, Ling Wei, Adam J. Lewis, K. Rachael Parks, John D. Aitchison, Alan Aderem, Robert Morrison, Alexis Kaushansky, Alyse N. Douglass, Nadia Arang
SummaryPrior to initiating symptomatic malaria, a single Plasmodium sporozoite infects a hepatocyte and develops into thousands of merozoites, in part by scavenging host resources. We show that host microtubules dynamically reorganize around the deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dd1023c5cb9b999a25fe8d49f9ca0f5
https://doi.org/10.1101/2020.08.31.275867
https://doi.org/10.1101/2020.08.31.275867
Autor:
Madeleine F. Jennewein, Leah J. Homad, Kristen W. Cohen, Junli Feng, M. Juliana McElrath, K. Rachael Parks, Rachael E Nelson, Nicholas R. Akins, Janet A. Englund, Helen Y. Chu, Andrew T. McGuire, Anna J. MacCamy, Leonidas Stamatatos, Yu-Hsin Wan, Suruchi Singh, Emilie Seydoux, Andrew B. Stuart, Nicholas K. Hurlburt, Marie Pancera
Publikováno v:
bioRxiv : the preprint server for biology.
B cells specific for the SARS-CoV-2 S envelope glycoprotein spike were isolated from a COVID-19-infected subject using a stabilized spike-derived ectodomain (S2P) twenty-one days post-infection. Forty-four S2P-specific monoclonal antibodies were gene
Autor:
Madeleine F. Jennewein, Marie Pancera, Suruchi Singh, M. Juliana McElrath, K. Rachael Parks, Andrew T. McGuire, Michael Boeckh, Emilie Seydoux, Rachael E. Whaley, Leah J. Homad, Andrew B. Stuart, Nicholas K. Hurlburt, Yu Hsin Wan, Nicholas R. Akins, Leonidas Stamatatos, Anna J. MacCamy, Helen Y. Chu, Janet A. Englund, Kristen W. Cohen, Junli Feng
Publikováno v:
Immunity
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
Antibody responses develop following SARS-CoV-2 infection, but little is known about their epitope specificities, clonality, binding affinities, epitopes and neutralizing activity. We isolated B cells specific for the SARS-CoV-2 envelope glycoprotein
Autor:
Andrew J. Borst, Brittany Takushi, K. Rachael Parks, Matthew D. Gray, Arineh Khechaduri, David Veesler, Po-Ssu Huang, Yu-Ru Lin, Jung-Ho Chun, Andrew O. Riker, Andrew B. Stuart, Marie Pancera, Anika S. Naidu, Leonidas Stamatatos, Parul Agrawal, Connor Weidle
Publikováno v:
Immunity
Summary Activating precursor B cell receptors of HIV-1 broadly neutralizing antibodies requires specifically designed immunogens. Here, we compared the abilities of three such germline-targeting immunogens against the VRC01-class receptors to activat
Autor:
Kevin A. Roth, Lisa D Speake, Talene A. Yacoubian, Yasuo Uchiyama, Takeshi Iwatsubo, Scott M. Wilson, Stephen L. Crimmins, David G. Standaert, Jianhua Zhang, Ken C. Walls, John J. Shacka, Qiuli Liang, Zuo-Lei Xie, Liyan Qiao, Lisheng Peng, YouMing Lu, Rachael Parks, Donna M. Crabtree, Shusei Hamamichi, Kim A. Caldwell, Yi Zhou, Guy A. Caldwell, Lonnie Schneider
Publikováno v:
Scopus-Elsevier
Molecular Brain
Molecular Brain, Vol 1, Iss 1, p 17 (2008)
Molecular Brain
Molecular Brain, Vol 1, Iss 1, p 17 (2008)
α-synuclein (α-syn) is a main component of Lewy bodies (LB) that occur in many neurodegenerative diseases, including Parkinson's disease (PD), dementia with LB (DLB) and multi-system atrophy. α-syn mutations or amplifications are responsible for a