Zobrazeno 1 - 10
of 231
pro vyhledávání: '"Rachael Natrajan"'
Autor:
Mohammed Inayatullah, Arun Mahesh, Arran K Turnbull, J Michael Dixon, Rachael Natrajan, Vijay K Tiwari
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 4, Pp 823-853 (2024)
Abstract Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, characterized by extensive intratumoral heterogeneity, high metastasis, and chemoresistance, leading to poor clinical outcomes. Despite progress, the mechanis
Externí odkaz:
https://doaj.org/article/f9d72b0bea3548a1b9749e30da03cd30
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract Subclonal heterogeneity and evolution are characteristics of breast cancer that play a fundamental role in tumour development, progression and resistance to current therapies. In this review, we focus on the recent advances in understanding
Externí odkaz:
https://doaj.org/article/dbfbbdf73e7441ab9e9cae05248cd3bf
Autor:
Julia Stevenson, Rachel Barrow-McGee, Lu Yu, Angela Paul, David Mansfield, Julie Owen, Natalie Woodman, Rachael Natrajan, Syed Haider, Cheryl Gillett, Andrew Tutt, Sarah E. Pinder, Jyoti Choudary, Kalnisha Naidoo
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract In breast cancer (BC), detecting low volumes of axillary lymph node (ALN) metastasis pre-operatively is difficult and novel biomarkers are needed. We recently showed that patient-derived ALNs can be sustained ex-vivo using normothermic perfu
Externí odkaz:
https://doaj.org/article/faec4d711cb34b769d96bb88a3e5b5c2
Autor:
Amin Emad, Tania Ray, Tor W. Jensen, Meera Parat, Rachael Natrajan, Saurabh Sinha, Partha S. Ray
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-13 (2020)
Abstract Background Cancer cells are known to display varying degrees of metastatic propensity, but the molecular basis underlying such heterogeneity remains unclear. Our aims in this study were to (i) elucidate prognostic subtypes in primary tumors
Externí odkaz:
https://doaj.org/article/8c6e3fa75e664d70af70f484a94725e7
Autor:
Saira Khalique, Stephen J Pettitt, Ger Kelly, Nina Tunariu, Rachael Natrajan, Susana Banerjee, Christopher J Lord
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 6, Iss 1, Pp 3-11 (2020)
Abstract Development of resistance to platinum and poly(ADP‐ribose) polymerase inhibitors via secondary BRCA gene mutations that restore functional homologous recombination has been observed in a number of cancer types. Here we report a case of som
Externí odkaz:
https://doaj.org/article/e8f9e42757ad4610a7b154b67b6a4093
Autor:
Laura Gómez-Cuadrado, Esme Bullock, Zeanap Mabruk, Hong Zhao, Margarita Souleimanova, Pernille Rimmer Noer, Arran K. Turnbull, Claus Oxvig, Nicholas Bertos, Adam Byron, J. Michael Dixon, Morag Park, Syed Haider, Rachael Natrajan, Andrew H. Sims, Valerie G. Brunton
Publikováno v:
Cancers, Vol 14, Iss 4, p 904 (2022)
Invasive lobular carcinoma (ILC) is the second most common histological subtype of breast cancer, and it exhibits a number of clinico-pathological characteristics distinct from the more common invasive ductal carcinoma (IDC). We set out to identify a
Externí odkaz:
https://doaj.org/article/8193455d5cc14900bb699a1273e6f061
Assessment of the Molecular Heterogeneity of E-Cadherin Expression in Invasive Lobular Breast Cancer
Autor:
John Alexander, Odette Mariani, Celine Meaudre, Laetitia Fuhrmann, Hui Xiao, Kalnisha Naidoo, Andrea Gillespie, Ioannis Roxanis, Anne Vincent-Salomon, Syed Haider, Rachael Natrajan
Publikováno v:
Cancers, Vol 14, Iss 2, p 295 (2022)
Mutations and loss of E-cadherin protein expression define the vast majority of invasive lobular carcinomas. In a subset of these cases, the heterogeneous expression of E-cadherin is observed either as wild-type (strong membranous) expression or aber
Externí odkaz:
https://doaj.org/article/50b25974570948959d5803e11656e336
Autor:
Saira Khalique, Sarah Nash, David Mansfield, Julian Wampfler, Ayoma Attygale, Katherine Vroobel, Harriet Kemp, Richard Buus, Hannah Cottom, Ioannis Roxanis, Thomas Jones, Katharina von Loga, Dipa Begum, Naomi Guppy, Pradeep Ramagiri, Kerry Fenwick, Nik Matthews, Michael J. F. Hubank, Christopher J. Lord, Syed Haider, Alan Melcher, Susana Banerjee, Rachael Natrajan
Publikováno v:
Cancers, Vol 13, Iss 15, p 3854 (2021)
Ovarian clear cell carcinoma (OCCC) is a rare subtype of epithelial ovarian cancer characterised by a high frequency of loss-of-function ARID1A mutations and a poor response to chemotherapy. Despite their generally low mutational burden, an intratumo
Externí odkaz:
https://doaj.org/article/4572fce1c8e0454eb8e4726155bb806e
Autor:
James Campbell, Colm J. Ryan, Rachel Brough, Ilirjana Bajrami, Helen N. Pemberton, Irene Y. Chong, Sara Costa-Cabral, Jessica Frankum, Aditi Gulati, Harriet Holme, Rowan Miller, Sophie Postel-Vinay, Rumana Rafiq, Wenbin Wei, Chris T. Williamson, David A. Quigley, Joe Tym, Bissan Al-Lazikani, Timothy Fenton, Rachael Natrajan, Sandra J. Strauss, Alan Ashworth, Christopher J. Lord
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2490-2501 (2016)
One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to profile genetic dependencies in cancer cell lines. Here, we describe data from a series of siRNA screens that identify the kinase genetic dependencies in 117 ca
Externí odkaz:
https://doaj.org/article/381f961b73404d2fa41627417ce941fc
Autor:
Rachael Natrajan, Heba Sailem, Faraz K Mardakheh, Mar Arias Garcia, Christopher J Tape, Mitch Dowsett, Chris Bakal, Yinyin Yuan
Publikováno v:
PLoS Medicine, Vol 13, Iss 2, p e1001961 (2016)
BackgroundThe intra-tumor diversity of cancer cells is under intense investigation; however, little is known about the heterogeneity of the tumor microenvironment that is key to cancer progression and evolution. We aimed to assess the degree of micro
Externí odkaz:
https://doaj.org/article/35ff3f6e44eb4dfeadeb84a0e001c74e