Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rachael N. McVicar"'
Autor:
Aaron F. Carlin, James R. Beadle, Alex E. Clark, Kendra L. Gully, Fernando R. Moreira, Ralph S. Baric, Rachel L. Graham, Nadejda Valiaeva, Sandra L. Leibel, William Bray, Rachel E. McMillan, Jonathan E. Freshman, Aaron F. Garretson, Rachael N. McVicar, Tariq Rana, Xing-Quan Zhang, Joyce A. Murphy, Robert T. Schooley, Karl Y. Hostetler
Publikováno v:
Journal of Medicinal Chemistry. 66:5802-5819
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23ce6028f5c0e95a9874dc2527a27c35
https://doi.org/10.1021/acs.jmedchem.3c00046
https://doi.org/10.1021/acs.jmedchem.3c00046
Autor:
Sandra L. Leibel, Rachael N. McVicar, Rabi Murad, Elizabeth M. Kwong, Alex E. Clark, Asuka Alvarado, Bethany A. Grimmig, Ruslan Nuryyev, Randee E. Young, Jamie Casey Lee, Weiqi Peng, Yanfang Peipei Zhu, Eric Griffis, Cameron J. Nowell, Kang Liu, Brian James, Suzie Alarcon, Atul Malhotra, Linden J. Gearing, Paul J. Hertzog, Cheska Marie Galapate, Koen M.O. Galenkamp, Cosimo Commisso, Davey M. Smith, Xin Sun, Aaron F. Carlin, Ben A. Croker, Evan Y. Snyder
Publikováno v:
bioRxiv
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) causes an acute respiratory distress syndrome (ARDS) that resembles surfactant deficient RDS. Using a novel multi-cell type, human induced pluripotent stem cell (hiPSC)-derived lung organoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176b7be3e6c03821db5f1393dae1180d
https://doi.org/10.1101/2023.01.26.525578
https://doi.org/10.1101/2023.01.26.525578
Autor:
Joy S. Xiang, Jasmine R. Mueller, En-Ching Luo, Brian A. Yee, Danielle Schafer, Jonathan C. Schmok, Frederick E. Tan, Katherine Rothamel, Rachael N. McVicar, Elizabeth M. Kwong, Krysten L. Jones, Hsuan-Lin Her, Chun-Yuan Chen, Anthony Q. Vu, Wenhao Jin, Samuel S. Park, Phuong Le, Kristopher W. Brannan, Eric R. Kofman, Yanhua Li, Alexandra T. Tankka, Kevin D. Dong, Yan Song, Aaron F. Carlin, Eric L. Van Nostrand, Sandra L. Leibel, Gene W. Yeo
Publikováno v:
bioRxiv : the preprint server for biology.
The COVID-19 pandemic is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The betacoronvirus has a positive sense RNA genome which encodes for several RNA binding proteins. Here, we use enhanced crosslinking and immunoprecipita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4eb01b328b38803794eef42ab397b30
https://pubmed.ncbi.nlm.nih.gov/35233578
https://pubmed.ncbi.nlm.nih.gov/35233578
Autor:
K.I. Agladze, Ibrahim Akin, Michail A. Alterman, Abdolreza Ardeshirylajimi, Alessia Bertero, Rahulkumar Bhoi, Natacha Breuls, Anne Bush, Francesca Caloni, Ivan Carcamo-Orive, Zhifen Chen, Teresa Coccini, Massimo Conese, Chad A. Cowan, Nathan James Cunningham, Ibrahim El-Battrawy, Benjamin S. Freedman, Andrée Gauthier-Fisher, Melkamu Getie-Kebtie, Nefele Giarratana, Madelyn A. Gillentine, Christopher Grunseich, Mirabelle S.H. Ho, Miriel S.H. Ho, Deborah A. Hursh, Gentaro Ikeda, Ji Hye Jung, Martin H. Kang, Yong Kyun Kim, Jacqueline Kowitz, Siegfried Lang, Onofrio Laselva, Jennifer Lei, Sandra L. Leibel, Clifford L. Librach, Geoffrey P. Lomax, Maryam Mahmoodinia Maymand, Rachael N. McVicar, Andrew R. Mendelsohn, Anna R. Mendelsohn, Sadegh lotfalah Moradi, Yasuhiro Murakawa, Dan Nir, Connor G. O'Brien, A.D. Podgurskaya, Natalia S. Pripuzova, Maurilio Sampaolesi, M.M. Slotvitsky, Evan Y. Snyder, Shi Su, Colin Sweeney, Bernard Thébaud, V.A. Tsvelaya, Haritha Vallabhaneni, Evgeniya A. Vaskova, Huaxiao Yang, Phillip C. Yang, Laura Yedigaryan, Masahito Yoshihara, Xiaobo Zhou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d308ba69a79386fc00d6f4eab904758
https://doi.org/10.1016/b978-0-323-99892-5.01002-1
https://doi.org/10.1016/b978-0-323-99892-5.01002-1
Publikováno v:
Journal of Visualized Experiments.
Human lung development and disease has been difficult to study due to the lack of biologically relevant in vitro model systems. Human induced pluripotent stem cells (hiPSCs) can be differentiated stepwise into 3D multicellular lung organoids, made of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abdcde660b85792dd8e9eefdc165be1
https://doi.org/10.3791/62456-v
https://doi.org/10.3791/62456-v
Autor:
En-Ching Luo, Anthony Q. Vu, Eric Kofman, Sandra L Leibel, Aaron F. Carlin, Eric L. Van Nostrand, Jonathan C. Schmok, Elizabeth M. Kwong, Danielle Schafer, Brian A. Yee, Gene W. Yeo, Jasmine R. Mueller, Frederick E. Tan, Joy Shengnan Xiang, Yan Song, Kristopher W. Brannan, Alexandra T. Tankka, Yanhua Li, Phuong Le, Kevin D. Dong, Hsuan-Lin Her, Samuel S. Park, Krysten Leigh Jones, Rachael N. McVicar, Chun-Yuan Chen, Wenhao Jin
Publikováno v:
SSRN Electronic Journal.
The COVID-19 pandemic was caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). Here, we use enhanced crosslinking and immunoprecipitation to investigate SARS-CoV-2 protein interactions with viral and host RNAs. SARS-CoV-2 proteins,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e8325d3972ef205518f90d9b11f87cc
https://doi.org/10.2139/ssrn.3867726
https://doi.org/10.2139/ssrn.3867726
Autor:
Ryan N. Porell, Sandra L Leibel, Jonathan L. Torres, Chelsea D. Painter, Aaron F. Carlin, Aaron F. Garretson, Gregory J. Golden, Elizabeth M. Kwong, Rachael N. McVicar, Timothy M. Caradonna, Philip L.S.M. Gordts, Andrew B. Ward, Sumit K. Chanda, Daniel R. Sandoval, Zhang Yang, Benjamin P. Kellman, Blake M. Hauser, Charles A. Glass, Jessica Pihl, Kevin D. Corbett, Joyce Jose, Cameron Martino, Sydney A. Majowicz, Jeffrey D. Esko, Charlotte B Spliid, Xin Yin, Bryan E. Thacker, Aaron G. Schmidt, Anoop Narayanan, Kamil Godula, Hailee R. Perrett, Jared Feldman, Logan K. Laubach, Phillip L. Bartels, Thomas Mandel Clausen, Yuan Pu
Publikováno v:
Cell, vol 183, iss 4
Cell
Cell
We show that SARS-CoV-2 spike protein interacts with both cellular heparan sulfate and angiotensin-converting enzyme 2 (ACE2) through its receptor-binding domain (RBD). Docking studies suggest a heparin/heparan sulfate-binding site adjacent to the AC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a75e2afde17a8be9e8115c9a6dd2ee6
https://escholarship.org/uc/item/232927v1
https://escholarship.org/uc/item/232927v1
Autor:
Aaron F. Carlin, Karl Y. Hostetler, Rachael N. McVicar, Xing-Quan Zhang, James R. Beadle, Joyce Murphy, Victoria I Smith, Robert T. Schooley, Rachel E McMillan, Alex E. Clark, Jialei Xie, Sandra L Leibel, Aaron F. Garretson, Nadejda Valiaeva
Publikováno v:
Antimicrobial Agents and Chemotherapy
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
Remdesivir (RDV; GS-5734) is currently the only FDA-approved antiviral drug for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The drug is approved for use in adults or children 12 years or older who are hosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75481230fe8e809586c86361447898ac
https://pubmed.ncbi.nlm.nih.gov/34310217
https://pubmed.ncbi.nlm.nih.gov/34310217
Autor:
Aaron G. Schmidt, Gordts, Plsm, Chanda, S. K., Cameron Martino, Blake M. Hauser, Thomas Mandel Clausen, Yuan Pu, Sydney A. Majowicz, Rachael N. McVicar, Charlotte B Spliid, Sandra L Leibel, Xin Yin, Daniel R. Sandoval, Jonathan L. Torres, Benjamin P. Kellman, Timothy M. Caradonna, E. M. Kwong, Ryan N. Porell, Kamil Godula, Charles A. Glass, Aaron F. Carlin, Bryan E. Thacker, Jessica Pihl, Kevin D. Corbett, Andrew B. Ward, Jared Feldman, Hailee R. Perrett, Jeffrey D. Esko, Logan K. Laubach, Chelsea D. Painter, Anoop Narayanan, Phillip L. Bartels, Aaron F. Garretson, Gregory J. Golden, Joyce Jose, Zhang Yang
Publikováno v:
bioRxiv
We show that SARS-CoV-2 spike protein interacts with cell surface heparan sulfate and angiotensin converting enzyme 2 (ACE2) through its Receptor Binding Domain. Docking studies suggest a putative heparin/heparan sulfate-binding site adjacent to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a9950cb2eacc5605613b031b210508
https://europepmc.org/articles/PMC7373134/
https://europepmc.org/articles/PMC7373134/