Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Rachael M. Zemek"'
Autor:
Wee Loong Chin, Rachael M. Zemek, Caitlin M. Tilsed, Alistair R. R. Forrest, Vanessa S. Fear, Catherine Forbes, Louis Boon, Anthony Bosco, Belinda B. Guo, Michael J. Millward, Anna K. Nowak, Richard A. Lake, W. Joost Lesterhuis, Timo Lassmann
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-9 (2024)
Abstract Time-critical transcriptional events in the immune microenvironment are important for response to immune checkpoint blockade (ICB), yet these events are difficult to characterise and remain incompletely understood. Here, we present whole tum
Externí odkaz:
https://doaj.org/article/a6b9ffd96f4e40b6b71f12cbc7e2efb8
Autor:
Francois Xavier Rwandamuriye, Breana Vitali, Juliët Schreurs, Tao Wang, Emily Barrick, Killugudi Swaminathan Iyer, Willem Joost Lesterhuis, Rachael M. Zemek, Ben Wylie
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 102948- (2024)
Summary: Pre-clinical studies developing novel therapies to prevent cancer recurrence require appropriate surgical models. Here, we present a protocol for surgical debulking of subcutaneous tumors in mice, which allows for intraoperative application
Externí odkaz:
https://doaj.org/article/403d255854b44e61bbaf50d99e6dd273
Autor:
Caitlin M. Tilsed, M. Lizeth Orozco Morales, Rachael M. Zemek, Brianna A. Gordon, Matthew J. Piggott, Anna K. Nowak, Scott A. Fisher, Richard A. Lake, W. Joost Lesterhuis
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-11 (2024)
Abstract Background Chemotherapy is included in treatment regimens for many solid cancers, but when administered as a single agent it is rarely curative. The addition of immune checkpoint therapy to standard chemotherapy regimens has improved respons
Externí odkaz:
https://doaj.org/article/604f2ab58dbd40a8bc1286fd39a00ca8
Autor:
Joel Kidman, Rachael M. Zemek, John-William Sidhom, Debora Correa, Nicola Principe, Fezaan Sheikh, Vanessa S. Fear, Catherine A. Forbes, Abha Chopra, Louis Boon, Ayham Zaitouny, Emma de Jong, Robert A. Holt, Matt Jones, Michael J. Millward, Timo Lassmann, Alistair R.R. Forrest, Anna K. Nowak, Mark Watson, Richard A. Lake, W. Joost Lesterhuis, Jonathan Chee
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTImmune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response. Using murine models that exclude
Externí odkaz:
https://doaj.org/article/f60545e051804f9796499b61db90824e
Autor:
Rachael M. Zemek, Wee Loong Chin, Vanessa S. Fear, Ben Wylie, Thomas H. Casey, Cath Forbes, Caitlin M. Tilsed, Louis Boon, Belinda B. Guo, Anthony Bosco, Alistair R. R. Forrest, Michael J. Millward, Anna K. Nowak, Richard A. Lake, Timo Lassmann, W. Joost Lesterhuis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Immune checkpoint blockade (ICB) is partially successful as a cancer therapy. Here using mouse models, the authors transcriptionally monitor responding and non-responding tumours showing that responding tumours were associated with transient IFN-β s
Externí odkaz:
https://doaj.org/article/59cfc35dd0fb4aa0a34e44f36234b216
Autor:
Caitlin M. Tilsed, Thomas H. Casey, Emma de Jong, Anthony Bosco, Rachael M. Zemek, Joanne Salmons, Graeme Wan, Michael J. Millward, Anna K. Nowak, Richard A. Lake, Willem Joost Lesterhuis
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
With immune checkpoint therapy (ICT) having reshaped the treatment of many cancers, the next frontier is to identify and develop novel combination therapies to improve efficacy. Previously, we and others identified beneficial immunological effects of
Externí odkaz:
https://doaj.org/article/19eeddb4bf7541cbb0eb578d199bb0ef
Autor:
M. Lizeth Orozco Morales, Catherine A. Rinaldi, Emma de Jong, Sally M. Lansley, Joel P.A. Gummer, Bence Olasz, Shabarinath Nambiar, Danika E. Hope, Thomas H. Casey, Y. C. Gary Lee, Connull Leslie, Gareth Nealon, David M. Shackleford, Andrew K. Powell, Marina Grimaldi, Patrick Balaguer, Rachael M. Zemek, Anthony Bosco, Matthew J. Piggott, Alice Vrielink, Richard A. Lake, W. Joost Lesterhuis
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103571- (2022)
Summary: Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and foun
Externí odkaz:
https://doaj.org/article/6d9c2a0cd5324c82ad3d7f092e5dbba3
Autor:
Nicola Principe, Joel Kidman, Siting Goh, Caitlin M. Tilsed, Scott A. Fisher, Vanessa S. Fear, Catherine A. Forbes, Rachael M. Zemek, Abha Chopra, Mark Watson, Ian M. Dick, Louis Boon, Robert A. Holt, Richard A. Lake, Anna K. Nowak, Willem Joost Lesterhuis, Alison M. McDonnell, Jonathan Chee
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Immune checkpoint therapy (ICT) results in durable responses in individuals with some cancers, but not all patients respond to treatment. ICT improves CD8+ cytotoxic T lymphocyte (CTL) function, but changes in tumor antigen-specific CTLs post-ICT tha
Externí odkaz:
https://doaj.org/article/14028b32db2541389131a67ac973ccfb
Autor:
Rachael M. Zemek, Wee Loong Chin, Anna K. Nowak, Michael J. Millward, Richard A. Lake, W. Joost Lesterhuis
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Immune checkpoint blockade (ICB) has revolutionized cancer treatment, providing remarkable clinical responses in some patients. However, the majority of patients do not respond. It is therefore crucial both to identify predictive biomarkers of respon
Externí odkaz:
https://doaj.org/article/c0ab4303f2fa4686a1db0102b6c02049
Autor:
M. Lizeth Orozco Morales, Catherine A. Rinaldi, Emma de Jong, Sally M. Lansley, Y. C. Gary Lee, Rachael M. Zemek, Anthony Bosco, Richard A. Lake, W. Joost Lesterhuis
Publikováno v:
PLOS ONE. 18:e0274364
Mesothelioma is characterised by its aggressive invasive behaviour, affecting the surrounding tissues of the pleura or peritoneum. We compared an invasive pleural model with a non-invasive subcutaneous model of mesothelioma and performed transcriptom