Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rachael M. Kenney"'
Publikováno v:
Analytical Chemistry. 95:3054-3061
Publikováno v:
Anal Methods
Oxygen is a transcriptional regulator responsible for tissue homeostasis and maintenance. Studies relating cellular phenotype with oxygen tension often use hypoxia chambers, which expose cells to a single, static oxygen tension. Despite their ease of
Publikováno v:
Arch Biochem Biophys
Hypoxia is a common feature in solid tumors. Clinical samples show a positive correlation between the expression of the hypoxia-inducible factor HIF-1α and estrogen receptor alpha (ERα) and a negative correlation between HIF-1α and hormone sensiti
Publikováno v:
The Analyst. 144:206-211
Cellular movement is essential in the formation and maintenance of healthy tissues as well as in disease progression such as tumor metastasis. In this work, we describe a paper-based Transwell assay capable of quantifying cellular invasion through an
Autor:
Brenden P. Kromhout, Nathan A. Whitman, Matthew R. Lockett, Rachael M. Kenney, Matthew W. Boyce
Publikováno v:
Analytical Chemistry. 90:2376-2383
Paper-based cultures are an emerging platform for preparing 3D tissue-like structures. Chemical gradients can be imposed upon these cultures, generating microenvironments similar to those found in poorly vascularized tumors. There is increasing evide
Publikováno v:
The Analyst. 141:661-668
Cellular migration is the movement of cells, cultured as a monolayer; cellular invasion is similar to migration, but requires the cells to move through a three-dimensional material such as basement membrane extract or a synthetic hydrogel. Migration
Publikováno v:
Analytical and Bioanalytical Chemistry. 408:2985-2992
Paper-based scaffolds are an attractive material for generating 3D tissue-like cultures because paper is readily available and does not require specialized equipment to pattern, cut, or use. By controlling the exchange of fresh culture medium with th
Publikováno v:
The FASEB Journal. 32
Publikováno v:
Chemical communications (Cambridge, England). 53(53)
Cellular invasion is the gateway to metastasis, which is the leading cause of cancer-related deaths. Invasion is driven by a number of chemical and mechanical stresses that arise in the tumor microenvironment. In vitro assays are needed for the syste
Publikováno v:
Biophysical chemistry. 216
Doxorubicin and nogalamycin are antitumor antibiotics that interact with DNA via intercalation and threading mechanisms, respectively. Because the importance of water, particularly its impact on entropy changes, has been established in other biologic