Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rachael M. Clarke"'
Autor:
Rachael M. Clarke, Claire E. Barry, Brian F. Deighan, Florence O’Connell, NG Anyakoha, Anthony Lyons, Anna Nicolaou, Marina A. Lynch
Publikováno v:
Journal of Biological Chemistry. 283:1808-1817
Inflammatory changes, characterized by an increase in pro-inflammatory cytokine production and up-regulation of the corresponding signaling pathways, have been described in the brains of aged rats and rats treated with the potent immune modulatory mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557b7c6a695720902bc52fe4290e8294
https://doi.org/10.1074/jbc.m707442200
https://doi.org/10.1074/jbc.m707442200
Autor:
Dana Kilroy, David J. Loane, Marina A. Lynch, Florence O’Connell, Aileen M. Lynch, Rachel E. Nally, Aedín M. Minogue, Óran J. Roche, Rachael M. Clarke
Publikováno v:
Neurobiology of Aging. 28:845-855
Among the changes that occur in the hippocampus with age, is a deficit in long-term potentiation (LTP). This impairment is associated with inflammatory changes, which are typified by increased concentration of the pro-inflammatory cytokine interleuki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c0d682100d8cc5cb3ab65001f81269
https://doi.org/10.1016/j.neurobiolaging.2006.04.006
https://doi.org/10.1016/j.neurobiolaging.2006.04.006
Publikováno v:
Journal of Neurochemistry. 101:771-781
It has been shown that Aβ inhibits long-term potentiation (LTP) in the rat hippocampus and this is accompanied by an increase in hippocampal concentration of IL-1β. Aβ also increases microglial activation, which is the likely cell source of IL-1β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16be33b028c7b9e50062c15306aa59b3
https://doi.org/10.1111/j.1471-4159.2006.04370.x
https://doi.org/10.1111/j.1471-4159.2006.04370.x
Publikováno v:
Journal of Neurochemistry. 96:1560-1571
There is compelling evidence to suggest that inflammation significantly contributes to neurodegenerative changes. Consistent with this is the observation that several neurodegenerative disorders are accompanied by an increase in the concentration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9993b8f655515938d3557af17e8bcc2d
https://doi.org/10.1111/j.1471-4159.2006.03664.x
https://doi.org/10.1111/j.1471-4159.2006.03664.x
Publikováno v:
Journal of Neuroinflammation, Vol 8, Iss 1, p 27 (2011)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however endogenous factors which contribute to the age-related increase in microglial activation remain largely unknown. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754878f56bda13393f080ec0f1a45e78
http://www.jneuroinflammation.com/content/8/1/27
http://www.jneuroinflammation.com/content/8/1/27
Autor:
Marina A. Lynch, David J. Loane, Rachael M. Clarke, Rebecca J. Griffin, Brian F. Deighan, Aileen M. Lynch
Publikováno v:
Neurobiology of aging. 30(6)
Increased expression of proinflammatory cytokines, like interleukin-1 beta (IL-1 beta), is a feature of the aged brain and it is generally accepted that the primary cell source of these cytokines is activated microglia. In hippocampus of aged rats, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b0986c5dd9497325f34434dc5f2d95
https://pubmed.ncbi.nlm.nih.gov/17950491
https://pubmed.ncbi.nlm.nih.gov/17950491
Publikováno v:
Journal of neurochemistry. 101(3)
It has been shown that Abeta inhibits long-term potentiation (LTP) in the rat hippocampus and this is accompanied by an increase in hippocampal concentration of IL-1beta. Abeta also increases microglial activation, which is the likely cell source of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef4f28ac5a5b096ee739b70a0cc9b84c
https://pubmed.ncbi.nlm.nih.gov/17250684
https://pubmed.ncbi.nlm.nih.gov/17250684
Publikováno v:
Journal of neurochemistry. 93(1)
Lipopolysaccharide (LPS) exerts a myriad of effects in rat hippocampus; it increases the concentration of the proinflammatory cytokine, interleukin-1beta (IL-1beta), and signalling via the IL-1 type I receptor (IL-1RI) resulting in phosphorylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a292c2e9871043bf1fdd971bf32cdb
https://pubmed.ncbi.nlm.nih.gov/15773921
https://pubmed.ncbi.nlm.nih.gov/15773921
Autor:
Miriam T. Brady, Marina A. Lynch, Frank O. Maher, Yvonne M. Nolan, Rachael M. Clarke, Anthony E. Bolton, Darren S.D. Martin, Kingston H. G. Mills
Publikováno v:
The Journal of biological chemistry. 280(10)
PUBLISHED
It is well documented that long term potentiation (LTP) is impaired in the hippocampus of the aged animal. Among the changes that contribute to this impairment is an increase in hippocampal concentration of the pro-inflammatory cytokin
It is well documented that long term potentiation (LTP) is impaired in the hippocampus of the aged animal. Among the changes that contribute to this impairment is an increase in hippocampal concentration of the pro-inflammatory cytokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8463ebae0d86c12947aa6e1047bb8ace
https://pubmed.ncbi.nlm.nih.gov/15615726
https://pubmed.ncbi.nlm.nih.gov/15615726