Výsledky vyhledávání - "Rachael Kimber"

Supplementary Movie 1 from An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression

AntilCOS

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https://doi.org/10.1158/2326-6066.22543483.v1

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Supplementary Figures from An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression

Supplementary Figures 1-9

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e902185bdfb8b67303be2284d9cf03dc
https://doi.org/10.1158/2326-6066.22543489.v1

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Supplementary Table 2 from An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression

Metadata for the 5 NSCLC patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1800b3397d3acb7f2682b1bdbfbacca6
https://doi.org/10.1158/2326-6066.22543474.v1

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Supplementary Movie 2 from An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression

Isotype control

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https://doi.org/10.1158/2326-6066.22543480

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Supplementary Figures and Tables Legend from An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression

Figure and tables legends of supplementary data

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https://doi.org/10.1158/2326-6066.22543492

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Data from An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression

The immunosuppressive tumor microenvironment constitutes a significant hurdle to immune checkpoint inhibitor responses. Both soluble factors and specialized immune cells, such as regulatory T cells (Treg), are key components of active intratumoral im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079b3a5625eeaea7fd185b7366ab732c
https://doi.org/10.1158/2326-6066.c.6550282

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Supplementary Table 1 from An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression

Genes used to define Immune cell subtypes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2e881e349e2a4082e5fe260954d2f0
https://doi.org/10.1158/2326-6066.22543477

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A novel antibody targeting ICOS increases intratumoural cytotoxic to regulatory T cell ratio and induces tumour regression

The immunosuppressive tumour microenvironment constitutes a significant hurdle to the response to immune checkpoint inhibitors. Both soluble factors and specialised immune cells such as regulatory T cells (TReg) are key components of active intratumo

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Abstract 4953: Differential expression of ICOS on circulating immune cells and tumor infiltrating lymphocytes in patient with solid tumors

Autor: David Melvin, Matthew McCourt, Anil K. Thotakura, Miha Kosmac, Gwenoline Bohris, Richard C.A. Sainson, Joana Carvalho, Rachael Kimber

Publikováno v: Cancer Research. 79:4953-4953

Background: The Inducible T-cell costimulator (ICOS/CD278) is upregulated during T cell activation and is an important regulator of the immune response against pathogens and cancer cells. When engaged by its ligand, the activation of ICOS signaling i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c6c618948449e712a862c5a285e630a9
https://doi.org/10.1158/1538-7445.am2019-4953

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