Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Rachael Keating"'
Autor:
Jocelyn G. Labombarde, Meenu R. Pillai, Marie Wehenkel, Chun-Yang Lin, Rachael Keating, Scott A. Brown, Jeremy Chase Crawford, David C. Brice, Ashley H. Castellaw, Alexandra H. Mandarano, Clifford S. Guy, Juan R. Mejia, Carlessia D. Lewis, Ti-Cheng Chang, Christine M. Oshansky, Sook-San Wong, Richard J. Webby, Mei Yan, Quan–Zhen Li, Tony N. Marion, Paul G. Thomas, Maureen A. McGargill
Publikováno v:
Cell Reports, Vol 38, Iss 10, Pp 110482- (2022)
Summary: Infection and vaccination repeatedly expose individuals to antigens that are conserved between influenza virus subtypes. Nevertheless, antibodies recognizing variable influenza epitopes greatly outnumber antibodies reactive against conserved
Externí odkaz:
https://doaj.org/article/ca04b47d87454606930f357a2413f564
Autor:
Rachael Keating, Jenny L. Johnson, David C. Brice, Jocelyn G. Labombarde, Alexander L. Dent, Maureen A. McGargill
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
ABSTRACT Enhancing the generation of broadly reactive antibodies against influenza A virus (IAV) is a pertinent goal toward developing a universal IAV vaccine. While antibodies that bind conserved IAV epitopes have been identified in humans, antibodi
Externí odkaz:
https://doaj.org/article/5b32c45fd4eb4b00b07f17f7bdc5be4e
Publikováno v:
Emerging Infectious Diseases, Vol 12, Iss 1, Pp 48-54 (2006)
Current vaccine strategies against influenza focus on generating robust antibody responses. Because of the high degree of antigenic drift among circulating influenza strains over the course of a year, vaccine strains must be reformulated specifically
Externí odkaz:
https://doaj.org/article/726dc50190ce47a59cc8c6454f36c1b2
Publikováno v:
Neuro-Oncology. 24:i134-i134
INTRODUCTION: Due to recent advancements in surgical techniques, imaging and adjuvant therapies, survival rates for children with central nervous system (CNS) tumours have improved. Research priorities have now shifted to focus on late-effects and qu
Autor:
Jenny L. Johnson, Maureen A. McGargill, Jocelyn G. Labombarde, Rachael Keating, Alexander L. Dent, David C. Brice
Publikováno v:
mBio
mBio, Vol 11, Iss 6 (2020)
mBio, Vol 11, Iss 6 (2020)
It is estimated that 250,000 to 650,000 individuals worldwide die each year from seasonal influenza A virus (IAV) infections. Current vaccines provide little protection against newly emerging strains. Thus, considerable effort is focused on enhancing
Autor:
Jocelyn G. Labombarde, Rachael Keating, Jenny L. Johnson, Alexander L. Dent, Maureen A. McGargill, David C. Brice
Enhancing the generation of broadly reactive influenza antibodies is a pertinent goal towards developing a universal influenza vaccine. While antibodies that bind conserved influenza epitopes have been identified in humans, the frequency of these ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc933e415abce50273ed32a0cc4eea6b
Autor:
Paul G. Thomas, Peter C. Doherty, Wen Yue, Melissa Y. Morris, Maureen A. McGargill, Cory Reynolds, Tarsha L. Harris, Rachael Keating, Scott A. Brown
Publikováno v:
Immunology and Cell Biology
Current influenza A virus (IAV) vaccines stimulate antibody responses that are directed against variable regions of the virus, and are therefore ineffective against divergent strains. As CD8+ T cells target the highly conserved, internal IAV proteins
Autor:
Maureen A. McGargill, Rachael Keating
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
Frontiers in Immunology
Frontiers in Immunology
Immunity to pathogens exists as a fine balance between promoting activation and expansion of effector cells, while simultaneously limiting normal and aberrant responses. These seemingly opposing functions are kept in check by immune regulators. The m
Publikováno v:
The Journal of Immunology. 200:125.11-125.11
Influenza infection continues to be a major health threat with over 9 million cases annually in the United States alone. Vaccination is the best method of preventing infection; however, current vaccines are only 10–60% effective due to a high mutat
Autor:
Wen Yue, Melissa Y. Morris, Richard J. Webby, Peter C. Doherty, John A. Rutigliano, Paul G. Thomas, Rachael Keating
Publikováno v:
Journal of Virology. 84:1047-1056
Human infections with highly pathogenic H5N1 avian influenza A viruses in the last decade have legitimized fears of a long-predicted pandemic. We thus investigated the response to secondary infections with an engineered, but still highly virulent, H5