Methodology for clinical genotyping of CYP2D6 and CYP2C19

Autor: Beatriz Carvalho Henriques, Avery Buchner, Xiuying Hu, Yabing Wang, Vasyl Yavorskyy, Keanna Wallace, Rachael Dong, Kristina Martens, Michael S. Carr, Bahareh Behroozi Asl, Joshua Hague, Sudhakar Sivapalan, Wolfgang Maier, Mojca Z. Dernovsek, Neven Henigsberg, Joanna Hauser, Daniel Souery, Annamaria Cattaneo, Ole Mors, Marcella Rietschel, Gerald Pfeffer, Stacey Hume, Katherine J. Aitchison

Publikováno v: Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract Many antidepressants, atomoxetine, and several antipsychotics are metabolized by the cytochrome P450 enzymes CYP2D6 and CYP2C19, and guidelines for prescribers based on genetic variants exist. Although some laboratories offer such testing, t

Externí odkaz: https://doaj.org/article/16d854a36fa943aab4f32e69d4f3a396

Single molecule long-read real-time amplicon-based sequencing of CYP2D6: a proof-of-concept with hybrid haplotypes

Autor: Rachael Dong, Megana Thamilselvan, Xiuying Hu, Beatriz Carvalho Henriques, Yabing Wang, Keanna Wallace, Sudhakar Sivapalan, Avery Buchner, Vasyl Yavorskyy, Kristina Martens, Wolfgang Maier, Neven Henigsberg, Joanna Hauser, Annamaria Cattaneo, Ole Mors, Marcella Rietschel, Gerald Pfeffer, Katherine J. Aitchison

CYP2D6 is a widely expressed human xenobiotic metabolizing enzyme, best known for its role in the hepatic phase I metabolism of up to 25% of prescribed medications, which is also expressed in other organs including the brain, where its potential role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0750d28952c9693c34d8b27c237fa10e
https://doi.org/10.1101/2022.08.17.503990

Methodology for clinical genotyping of CYP2D6 and CYP2C19

Autor: Kristina Martens, Vasyl Yavorskyy, Ole Mors, Joshua Hague, Wolfgang Maier, Daniel Souery, Neven Henigsberg, Gerald Pfeffer, Rachael Dong, Annamaria Cattaneo, Joanna Hauser, Marcella Rietschel, Keanna Wallace, Avery Buchner, Stacey Hume, Michael Carr, Yabing Wang, Bahareh Behroozi Asl, Mojca Z. Dernovsek, Sudhakar Sivapalan, Katherine J. Aitchison, Beatriz Carvalho Henriques, Xiuying Hu

Publikováno v: Translational Psychiatry
Carvalho Henriques, B, Buchner, A, Hu, X, Wang, Y, Yavorskyy, V, Wallace, K, Dong, R, Martens, K, Carr, M S, Behroozi Asl, B, Hague, J, Sivapalan, S, Maier, W, Dernovsek, M Z, Henigsberg, N, Hauser, J, Souery, D, Cattaneo, A, Mors, O, Rietschel, M, Pfeffer, G, Hume, S & Aitchison, K J 2021, ' Methodology for clinical genotyping of CYP2D6 and CYP2C19 ', Translational Psychiatry, vol. 11, no. 1, 596 . https://doi.org/10.1038/s41398-021-01717-9
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)

Many antidepressants, atomoxetine, and several antipsychotics are metabolized by the cytochrome P450 enzymes CYP2D6 and CYP2C19, and guidelines for prescribers based on genetic variants exist. Although some laboratories offer such testing, there is n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbda9fb5d1be2e4b6d723589b333df69
https://doi.org/10.1038/s41398-021-01717-9

Evaluation of five additives to mitigate toxicity of cryoprotective agents on porcine chondrocytes

Autor: Nadr M. Jomha, Kezhou Wu, Rachael Dong, Leila Laouar, Janet A.W. Elliott

Publikováno v: Cryobiology. 88:98-105

Cryoprotective agents (CPAs) are used in cryopreservation protocols to achieve vitrification. However, the high CPA concentrations required to vitrify a tissue such as articular cartilage are a major drawback due to their cellular toxicity. Oxidation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e637f51aa52909d39e7025e2f8bff13f
https://doi.org/10.1016/j.cryobiol.2019.02.004

Optimization of additives to mitigate chondrocyte toxicity during exposure to cryoprotective agents

Autor: Locksley E. McGann, Rachael Dong, Janet A.W. Elliot, Leila Laouar, Kezhou Wu, Nadr M. Jomha

Publikováno v: Cryobiology. 80:180

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::afd484451d1c0ffa611c42fa801dea59
https://doi.org/10.1016/j.cryobiol.2017.10.101