Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response

Autor: Mongkol Lao-araya, Stephen R. Durham, Oliver Hunewald, Anke-Hilse Maitland-van der Zee, Balthasar A. Heesters, Janice A. Layhadi, Gemma Vilà-Nadal, Korneliusz Golebski, Esther H. Steveling-Klein, Mohamed H. Shamji, Rachael C.Y. Li, Suzanne M. Bal, Wytske Fokkens, Cornelis M. van Drunen, Feng He, Umit Murat Sahiner, Susanne J. H. Vijverberg, Markus Ollert, Oleksandra Fedina, Madison M. Lenormand, Hergen Spits, Guillem Montamat

Publikováno v: Immunity, 54(2), 291-307.e7. Cell Press
Immunity, 54(2), 291. Cell Press
307.e7
Golebski, K, Layhadi, J A, Sahiner, U, Steveling-Klein, E H, Lenormand, M M, Li, R C Y, Bal, S M, Heesters, B A, Vilà-Nadal, G, Hunewald, O, Montamat, G, He, F Q, Ollert, M, Fedina, O, Lao-Araya, M, Vijverberg, S J H, Maitland-van der Zee, A H, van Drunen, C M, Fokkens, W J, Durham, S R, Spits, H & Shamji, M H 2021, ' Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response ', Immunity, vol. 54, no. 2, pp. 291-307.e7 . https://doi.org/10.1016/j.immuni.2020.12.013

The role of innate immune cells in allergen immunotherapy that confers immune tolerance to the sensitizing allergen is unclear. Here, we report a role of interleukin-10-producing type 2 innate lymphoid cells (IL-10+ ILC2s) in modulating grass-pollen

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https://pure.amc.nl/en/publications/induction-of-il10producing-type-2-innate-lymphoid-cells-by-allergen-immunotherapy-is-associated-with-clinical-response(229380d1-a168-41ca-a2cf-67cf7a6c8968).html