Growth and Gastrointestinal Tolerance in Healthy Term Infants Fed Milk-Based Infant Formula Supplemented with Five Human Milk Oligosaccharides (HMOs): A Randomized Multicenter Trial

Autor: John Lasekan, Yong Choe, Svyatoslav Dvoretskiy, Amy Devitt, Sue Zhang, Amy Mackey, Karyn Wulf, Rachael Buck, Christine Steele, Michelle Johnson, Geraldine Baggs

Publikováno v: Nutrients, Vol 14, Iss 13, p 2625 (2022)

Background: Five of the most abundant human milk oligosaccharides (HMOs) in human milk are 2′-fucosyllactose (2′-FL), 3-fucosyllactose (3-FL), lacto-N-tetraose (LNT), 3′-sialyllactose (3′-SL) and 6′-sialyllactose (6′-SL). Methods: A rando

Externí odkaz: https://doaj.org/article/0ab4887553f545488e5d3400b79172ee

Dietary 2'-Fucosyllactose Enhances Operant Conditioning and Long-Term Potentiation via Gut-Brain Communication through the Vagus Nerve in Rodents.

Autor: Enrique Vazquez, Alejandro Barranco, Maria Ramirez, Agnes Gruart, Jose M Delgado-Garcia, Maria L Jimenez, Rachael Buck, Ricardo Rueda

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0166070 (2016)

2´-fucosyllactose (2´-FL) is an abundant human milk oligosaccharide (HMO) in human milk with diverse biological effects. We recently reported ingested 2´-FL stimulates central nervous system (CNS) function, such as hippocampal long term potentiati

Externí odkaz: https://doaj.org/article/0c5d57e02abd42c0be1427552c2ad6cb

The human milk oligosaccharides 2’-fucosyllactose and 6’-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling

Autor: Chhinder P. Sodhi, Sanxia Wang, Hongpeng Jia, Karen C. Goehring, Yukihiro Yamaguchi, Rachael Buck, Peter Wipf, Mitchell R. Ladd, William B. Fulton, David J. Hackam, Qinjie Zhou, Emilyn Banfield, Adam D. Werts, Mark L. Kovler, Diego F. Niño, Thomas Prindle, Peng Lu

Publikováno v: Pediatric research

Objective: Necrotizing enterocolitis (NEC) develops through exaggerated toll-like receptor 4 (TLR4) signaling in the intestinal epithelium. Breast milk is rich in non-digestible oligosaccharides and prevents NEC through unclear mechanisms. We now hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41a1085cc282809022d468fa739af3c
https://doi.org/10.1038/s41390-020-0852-3

Human Milk Oligosaccharides Attenuate Antigen-Antibody Complex Induced Chemokine Release from Human Intestinal Epithelial Cell Lines

Autor: Paul Forsythe, Ibrahim Khambati, Sehrish Zehra, Megan Vierhout, M. Firoz Mian, Rachael Buck

Publikováno v: Journal of Food Science. 83:499-508

There has been increased interest in the use of dietary ingredients, including prebiotics such as human‐milk oligosaccharides (HMOs), as therapeutic strategies for food allergy. Understanding the mechanisms underlying the beneficial effects of HMOs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e19a5629a9a1b814e6745ab21ab003f8
https://doi.org/10.1111/1750-3841.14039

A Novel Role for Necroptosis in the Pathogenesis of Necrotizing Enterocolitis

Autor: William B. Fulton, Karen C. Goehring, Chhinder P. Sodhi, Yukihiro Yamaguchi, Rachael Buck, Thomas Prindle, David J. Hackam, Qinjie Zhou, Emilyn Banfield, Mitchell R. Ladd, Yue X. Chen, Ali Saad-Eldin, Mark L. Kovler, Hongpeng Jia, Sanxia Wang, Peng Lu, Adam D. Werts

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 3, Pp 403-423 (2020)

Background & Aims Necrotizing enterocolitis (NEC) is a devastating disease of premature infants characterized by Toll-like receptor 4 (TLR4)-dependent intestinal inflammation and enterocyte death. Given that necroptosis is a proinflammatory cell deat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c648497098a842c9b3176f84f44d096a
https://pubmed.ncbi.nlm.nih.gov/31904352