Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Rachael A. Maplestone"'
Autor:
David E. Wemmer, Andrea M. Sefler, Paul A. Bartlett, Rachael A. Maplestone, Ho S. Cho, Witold N. Hruzewicz, Kim Liu, Corey W. Liu, Richard E. Austin
Publikováno v:
Journal of the American Chemical Society. 119:6461-6472
The bicyclic diacid 1 was designed as a semi-rigid template for the hydrogen-bonding pattern of a peptide α-helix. The protected precursor 7 was synthesized in eight steps from tert-butyl 3,5-dimet...
Publikováno v:
Journal of the American Chemical Society. 116:4573-4580
Publikováno v:
FEBS Letters. 326:95-100
An acyclic derivative of the cyclic peptide antibiotic, ramoplanin, has been prepared. In aqueous solution, two-dimensional NMR spectroscopy indicates that the acyclic form adopts a threshold population of conformers in which at least part of the β-
Publikováno v:
Journal of the American Chemical Society. 115:232-237
Evidence is presented for the formation or dimers in aqueous solutions or the glycopeptide antibiotics cremomycin, A82846B, vancomycin, and eremomycin-Ψ. The dimerization constant K dim is determined by 1 H NMR spectroscopy for the last two compound
Publikováno v:
Gene. 115:151-157
It is argued that organisms have evolved the ability to biosynthesise secondary metabolites ('natural products') due to the selectional advantages they obtain as a result of the functions of the compounds. Pleiotropic switching, the simultaneous expr
Publikováno v:
Tetrahedron Letters. 32:2663-2666
Syntheses of optically active 3,5-DMPG and racemic 3,5-DHPG, the latter suitably protected for incorporation into linear peptides modelled on vancomycin, are described and a synthesis of the optically pure protected C-terminal dipeptide of vancomycin