Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rachael A. Ancliff"'
Autor:
Steven Philip Keeling, Nigel J. Parr, Simon Teanby Hodgson, Ashley Paul Hancock, Duncan S. Holmes, Panayiotis A. Procopiou, James E. Rowedder, Brian Edgar Looker, Robert J. Slack, Paul Martin Gore, Rachael A. Ancliff
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5855-5859
A novel series of potent quinoline-based human H1 and H3 bivalent histamine receptor antagonists, suitable for intranasal administration for the potential treatment of allergic rhinitis associated nasal congestion, were identified. Compound 18b had s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d45d14b9a3273b85467445965e61386d
https://doi.org/10.1016/j.bmcl.2016.11.022
https://doi.org/10.1016/j.bmcl.2016.11.022
Autor:
Panayiotis A, Procopiou, Rachael A, Ancliff, Paul M, Gore, Ashley P, Hancock, Simon T, Hodgson, Duncan S, Holmes, Steven P, Keeling, Brian E, Looker, Nigel A, Parr, James E, Rowedder, Robert J, Slack
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(24)
A novel series of potent quinoline-based human H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df29cb22861cd8246a29f05e6ef16e73
https://pubmed.ncbi.nlm.nih.gov/27866818
https://pubmed.ncbi.nlm.nih.gov/27866818
The aldol products derived from sulfur- or selenium containing acceptors were prepared by kinetic resolution in the presence of antibody 84G3 with enantiomeric excesses ranging from 56 to 70%. Much higher level of enantioselectivity was obtained (ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97d545a1fd68a3fa9e8381d781e5e7a
https://ora.ox.ac.uk/objects/uuid:4d6d5fb6-859c-41b9-966e-9adc45a8b5b6
https://ora.ox.ac.uk/objects/uuid:4d6d5fb6-859c-41b9-966e-9adc45a8b5b6
Publikováno v:
Tetrahedron: Asymmetry. 8:3379-3382
Both the ( R ) and ( S ) enantiomers of the citric acid derivative 1 have been obtained in ≥90% ee via resolution of the racemate by fractional crystallisation of the ( S ) and ( R )- α -methylbenzylamine salts respectively. The stereochemistry of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::376fca2318cb988d4e3dede642cc0fd7
https://doi.org/10.1016/s0957-4166(97)00435-7
https://doi.org/10.1016/s0957-4166(97)00435-7
Autor:
Gemma Victoria White, Helen E. Connor, Elizabeth Pickup, David Matthew Wilson, Clarissa J. Watts, Christopher Browning, Sanjeet Singh Sehmi, Karen M. L. Morriss, Mark James Bamford, Christopher A. Parr, Susannah Davies, Brian Edgar Looker, Panayiotis A. Procopiou, Simon Teanby Hodgson, Fogden Yvonne C, Rachael A. Ancliff, Woodrow Michael David, Duncan S. Holmes
Publikováno v:
Journal of medicinal chemistry. 50(26)
A series of ketopiperazines were prepared and evaluated for their activity as histamine H 3 antagonists. From investigation of the tertiary basic center in the aminopropyloxyphenyl template, the 2( R)-methylpyrrolidine was identified as the most pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::379b02c58096cd697e1e8d0c03ea6702
https://pubmed.ncbi.nlm.nih.gov/18052318
https://pubmed.ncbi.nlm.nih.gov/18052318
Publikováno v:
ChemInform. 37
The selective reduction of one of the three carboxyl groups of two chiral citric acid derivatives to the corresponding aldehydes, under Rosenmund conditions, are reported together with the application of these aldehydes to the syntheses of the ester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8742cdfb80fa86c0bf4cf69a50f5488b
https://doi.org/10.1002/chin.200649204
https://doi.org/10.1002/chin.200649204
Autor:
Rachael A. Ancliff, Andrew T. Russell, Adam J. SandersonPresent address Eli Lilly and Company Ltd., Lilly Research Centre, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, UK GU20 6PH.
Publikováno v:
Chemical Communications; Jul2006, Vol. 2006 Issue 30, p3243-3245, 3p
Autor:
Panayiotis A. Procopiou, Rachael A. Ancliff, Mark J. Bamford, Christopher Browning, Helen Connor, Susannah Davies, Yvonne C. Fogden, Simon T. Hodgson, Duncan S. Holmes, Brian E. Looker, Karen M. L. Morriss, Christopher A. Parr, Elizabeth A. Pickup, Sanjeet S. Sehmi, Gemma V. White, Clarissa J. Watts, David M. Wilson, Michael D. Woodrow
Publikováno v:
Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 26, p6706-6717, 12p