Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rachael, Nimmo"'
Autor:
Jason P. Wray, Elitza M. Deltcheva, Charlotta Boiers, Simon Е Richardson, Jyoti Bikram Chhetri, John Brown, Sladjana Gagrica, Yanping Guo, Anuradha Illendula, Joost H. A. Martens, Hendrik G. Stunnenberg, John H. Bushweller, Rachael Nimmo, Tariq Enver
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The ETV6-RUNX1 chimeric- and native RUNX1-responsive regulomes in paediatric B-acute lymphoblastic leukemia (B-ALL) remain to be characterized. Here, the authors reveal functional antagonism between the two transcription factors predominantly for the
Externí odkaz:
https://doaj.org/article/57a324404a3a49c69acb08a4d571d807
Autor:
Rosie J. Munday, Tiziana Coradin, Rachael Nimmo, Yatish Lad, Stephen C. Hyde, Kyriacos Mitrophanos, Deborah R. Gill
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 239-252 (2022)
A lentiviral vector (LV) pseudotype derived from the fusion (F) and hemagglutinin-neuraminidase (HN) glycoproteins of a murine respirovirus (Sendai virus) facilitates efficient targeting of murine lung in vivo. Since targeting of the human lung will
Externí odkaz:
https://doaj.org/article/241605041a2345d097db4e7ae694bd95
Autor:
Jason P, Wray, Elitza M, Deltcheva, Charlotta, Boiers, Simon Е, Richardson, Jyoti Bikram, Chhetri, John, Brown, Sladjana, Gagrica, Yanping, Guo, Anuradha, Illendula, Joost H A, Martens, Hendrik G, Stunnenberg, John H, Bushweller, Rachael, Nimmo, Tariq, Enver
Publikováno v:
Nature communications. 13(1)
The ETV6-RUNX1 onco-fusion arises in utero, initiating a clinically silent pre-leukemic state associated with the development of pediatric B-acute lymphoblastic leukemia (B-ALL). We characterize the ETV6-RUNX1 regulome by integrating chromatin immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c883e810a27f170aa186fa48e53bfed1
https://pubmed.ncbi.nlm.nih.gov/36411286
https://pubmed.ncbi.nlm.nih.gov/36411286
Autor:
Masatake Araki, David C. Linch, Gillian May, Rachael Nimmo, P. Datta, Essam Ghazaly, Jane K. Howard, Graham M. Lord, J. Kasturiarachchi, Simon P. Brooks, Jamie Brown, Alan G. Marshall, Tariq Enver, Elitza Deltcheva, Asim Khwaja, Y. Guo, Nelomi Anandagoda, Chela James, Ian Jackson, Kimi Araki
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e97d49258016f69055e045fb76934bd
https://doi.org/10.1038/s41598-021-84578-y
https://doi.org/10.1038/s41598-021-84578-y
Autor:
Julia P. Gerber, Jenny Russ, Vijay Chandrasekar, Nina Offermann, Hang-Mao Lee, Sarah Spear, Nicola Guzzi, Simona Maida, Sundararaghavan Pattabiraman, Ruoyu Zhang, Amir H. Kayvanjoo, Preeta Datta, Jagath Kasturiarachchi, Teresa Sposito, Natalia Izotova, Kristian Händler, Peter D. Adams, Teresa Marafioti, Tariq Enver, Jörg Wenzel, Marc Beyer, Elvira Mass, Cristian Bellodi, Joachim L. Schultze, Melania Capasso, Rachael Nimmo, Paolo Salomoni
Publikováno v:
Nature cell biology 23(12), 1224-1239 (2021). doi:10.1038/s41556-021-00774-y
Nature Cell Biology
Nature Cell Biology
Defective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. However, the underlying mechanisms are only partially understood. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee13b2bcc75258f28371f3d227cfcfb
https://pub.dzne.de/record/163640
https://pub.dzne.de/record/163640
Autor:
Sladjana Gagrica, Simon Richardson, Jason Wray, Jyoti Bikram Chettri, Joost H.A. Martens, Anuradha Illendula, John H. Bushweller, Elitza Deltcheva, Yan-Ping Guo, Tariq Enver, Hendrik G. Stunnenberg, Rachael Nimmo, Charlotta Böiers
SummaryThe ETV6-RUNX1 onco-fusion arises in utero, initiating a clinically silent pre-leukemic state associated with the development of pediatric B-acute lymphoblastic leukemia (B-ALL). We characterize the ETV6-RUNX1 regulome by integrating chromatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cee28eace6b1c6895ce45cbfab03bc6
https://doi.org/10.1101/2020.12.22.423823
https://doi.org/10.1101/2020.12.22.423823
Autor:
Simon P. Brooks, J. Kasturiarachchi, Graham M. Lord, Jane K. Howard, Elitza Deltcheva, Asim Khwaja, David C. Linch, Tariq Enver, Kimi Araki, Rachael Nimmo, Alan G. Marshall, Nelomi Anandagoda, Chela James, P. Datta, Ian Jackson, Gillian May, Essam Ghazaly, Jamie Brown, Y. Guo, Masatake Araki
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
AML is a genetically heterogeneous disease and understanding how different co-occurring mutations cooperate to drive leukemogenesis will be crucial for improving diagnostic and therapeutic options for patients. MIR142 mutations have been recurrently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5148c5dd75bf379190529acc54d8ea42
http://europepmc.org/articles/PMC7656267
http://europepmc.org/articles/PMC7656267
Autor:
Graham M. Lord, Tomasz Zabinski, Emily Read, Luke B. Roberts, Kimi Araki, Murray E. Selkirk, Masatake Araki, Joana F. Neves, Jagath Kasturiarachchi, Rita Berkachy, Jane K. Howard, Geraldine M. Jowett, Umar Niazi, Tariq Enver, Nelomi Anandagoda, Chela James, Ian Jackson, Rita Antunes Dos Reis, Rachael Nimmo
Publikováno v:
The Journal of Immunology Author Choice
Key Points MicroRNA-142 isoforms critically regulate ILC2 homeostasis and effector functions. MicroRNA-142 isoforms regulate the ILC2 lineage cell intrinsically. Socs1 and Gfi1 are miR-142 isoform regulated targets in ILC2s.
Visual Abstract
Visual Abstract
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cb6b5b1684c70cda63da2e5cb5a54ac
https://pubmed.ncbi.nlm.nih.gov/34021046
https://pubmed.ncbi.nlm.nih.gov/34021046
Autor:
Julia P. Gerber, Jenny Russ, Vijay Chandrasekar, Nina Offermann, Hang-Mao Lee, Sarah Spear, Nicola Guzzi, Simona Maida, Sundararaghavan Pattabiraman, Ruoyu Zhang, Amir H. Kayvanjoo, Preeta Datta, Jagath Kasturiarachchi, Teresa Sposito, Natalia Izotova, Kristian Händler, Peter D. Adams, Teresa Marafioti, Tariq Enver, Jörg Wenzel, Marc Beyer, Elvira Mass, Cristian Bellodi, Joachim L. Schultze, Melania Capasso, Rachael Nimmo, Paolo Salomoni
Publikováno v:
Nature cell biology 24(1), 123 (2022). doi:10.1038/s41556-021-00833-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebfb1ecebddf3b1c239fcf6f7ed5ecc
https://doi.org/10.1038/s41556-021-00833-4
https://doi.org/10.1038/s41556-021-00833-4
Autor:
Rachael Nimmo, Elitza Deltcheva
Publikováno v:
The Biochemical journal. 474(11)
The RUNX1 transcription factor is a critical regulator of normal haematopoiesis and its functional disruption by point mutations, deletions or translocations is a major causative factor leading to leukaemia. In the majority of cases, genetic changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92363704054c3d47a5199a7b3786ec61
https://pubmed.ncbi.nlm.nih.gov/28490659
https://pubmed.ncbi.nlm.nih.gov/28490659