Bedaquiline and clofazimine resistance in Mycobacterium tuberculosis: an in-vitro and in-silico data analysis

Autor: Sonnenkalb, Lindsay, Carter, Joshua James, Spitaleri, Andrea, Iqbal, Zamin, Hunt, Martin, Malone, Kerri Marie, Utpatel, Christian, Cirillo, Daniela Maria, Rodrigues, Camilla, Nilgiriwala, Kayzad Soli, Fowler, Philip William, Merker, Matthias, Niemann, Stefan, Consortium, The Comprehensive Resistance Prediction for Tuberculosis: an International, Barilar, I, Battaglia, S, Borroni, E, Brandao, AP, Brankin, A, Cabibbe, AM, Carter, J, Claxton, P, Clifton, DA, Cohen, T, Coronel, J, Crook, DW, Dreyer, V, Earle, SG, Escuyer, V, Ferrazoli, L, Fowler, PW, Gao, G Fu, Gardy, J, Gharbia, S, Ghisi, KT, Ghodousi, A, Cruz, AL Gibertoni, Grandjean, L, Grazian, C, Groenheit, R, Guthrie, JL, He, W, Hoffmann, H, Hoosdally, SJ, Ismail, NA, Jarrett, L, Joseph, L, Jou, R, Kambli, P, Khot, R, Knaggs, J, Koch, A, Kohlerschmidt, D, Kouchaki, S, Lachapelle, AS, Lalvani, A, Lapierre, S Grandjean, Laurenson, IF, Letcher, B, Lin, WH, Liu, C, Liu, D, Malone, KM, Mandal, A, Mansjö, M, Matias, D, Meintjes, G, de Freitas Mendes, F, Mihalic, M, Millard, J, Miotto, P, Mistry, N, Moore, D, Musser, KA, Ngcamu, D, Hoang, NN, Nimmo, C, Okozi, N, Oliveira, RS, Omar, SV, Paton, N, Peto, TE, Pinhata, JM Watanabe, Plesnik, S, Puyen, ZM, Rabodoarivelo, MS, Rakotosamimanana, N, Rancoita, PM, Rathod, P, Rodger, G, Rodwell, TC, Roohi, E, Santos-Lazaro, D, Shah, S, Kohl, TA, Smith, G, Solano, W, Supply, P, Surve, U, Tahseen, S, Thuong, NTT

Background: Bedaquiline is a core drug for the treatment of multidrug-resistant tuberculosis; however, the understanding of resistance mechanisms is poor, which is hampering rapid molecular diagnostics. Some bedaquiline-resistant mutants are also cro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d3dc1aaf8f396193628850666e402b6

Evaluation of critical parameters in the hollow-fibre system for tuberculosis: A case study of moxifloxacin.

Autor: Aguilar-Ayala DA; Department of Microbiology, Pediatrics, Radiology and Public Health, University of Zaragoza, Zaragoza, Spain., Sanz-García F; Department of Microbiology, Pediatrics, Radiology and Public Health, University of Zaragoza, Zaragoza, Spain., Rabodoarivelo MS; Department of Microbiology, Pediatrics, Radiology and Public Health, University of Zaragoza, Zaragoza, Spain., Susanto BO; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden., Bailo R; Department of Microbiology, Pediatrics, Radiology and Public Health, University of Zaragoza, Zaragoza, Spain., Eveque-Mourroux MR; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, Lille, France., Willand N; Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, Lille, France., Simonsson USH; Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden., Ramón-García S; Department of Microbiology, Pediatrics, Radiology and Public Health, University of Zaragoza, Zaragoza, Spain.; Spanish Network for Research on Respiratory Diseases (CIBERES), Carlos III Health Institute, Madrid, Spain.; Research and Development Agency of Aragón (ARAID) Foundation, Zaragoza, Spain., Lucía A; Department of Microbiology, Pediatrics, Radiology and Public Health, University of Zaragoza, Zaragoza, Spain.; Spanish Network for Research on Respiratory Diseases (CIBERES), Carlos III Health Institute, Madrid, Spain.

Publikováno v: British journal of clinical pharmacology [Br J Clin Pharmacol] 2024 Jul; Vol. 90 (7), pp. 1711-1727. Date of Electronic Publication: 2024 Apr 17.

Complexities and benefits of adopting next-generation sequencing-based tuberculosis diagnostics: a qualitative study among stakeholders in low and high-income countries.

Autor: Grandjean Lapierre S; Mycobacteria Unit, Institut Pasteur Madagascar, Antananarivo, Madagascar.; Microbiology, Infectious Diseases and Immunology Department, Université de Montréal, Montreal, Québec, Canada., Nouvet E; School of Health Studies, Western University, London, Ontario, Canada enouvet@uwo.ca., Boutin CA; Microbiology, Infectious Diseases and Immunology Department, Université de Montréal, Montreal, Québec, Canada., Rabodoarivelo MS; Mycobacteria Unit, Institut Pasteur Madagascar, Antananarivo, Madagascar.; Departamento de Microbiología, Pediatría, Radiología y Salud Pública, Universidad de Zaragoza, Zaragoza, Spain., Mahboob O; Florida State University College of Medicine, Florida State University, Tallahassee, Florida, USA., Smith MJ; School of Health Studies, Western University, London, Ontario, Canada., Rakotosamimanana N; Institut Pasteur de Madagascar, Antananarivo, Madagascar.

Publikováno v: BMJ open [BMJ Open] 2023 Apr 10; Vol. 13 (4), pp. e066651. Date of Electronic Publication: 2023 Apr 10.

Evaluation of Nanopore sequencing for Mycobacterium tuberculosis drug susceptibility testing and outbreak investigation: a genomic analysis.

Autor: Hall MB; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK., Rabodoarivelo MS; Mycobacteriology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar; Departamento de Microbiología, Medicina Preventiva y Salud Pública, Universidad de Zaragoza, Zaragoza, Spain., Koch A; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit and DST-NRF Centre of Excellence for Biomedical TB Research, Department of Pathology, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Dippenaar A; Department of Science and Innovation-National Research Foundation Centre for Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa; Tuberculosis Omics Research Consortium, Family Medicine and Population Health, Institute of Global Health, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium., George S; Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford University, Oxford, UK., Grobbelaar M; Department of Science and Innovation-National Research Foundation Centre for Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa., Warren R; Department of Science and Innovation-National Research Foundation Centre for Excellence for Biomedical Tuberculosis Research, SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa., Walker TM; Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam., Cox H; Division of Medical Microbiology, Department of Pathology, University of Cape Town, Cape Town, South Africa; Wellcome Centre for Infectious Disease Research in Africa, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Gagneux S; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland., Crook D; Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford University, Oxford, UK., Peto T; Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford University, Oxford, UK., Rakotosamimanana N; Mycobacteriology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar., Grandjean Lapierre S; Mycobacteriology Unit, Institut Pasteur de Madagascar, Antananarivo, Madagascar; Department of Microbiology, Infectious Diseases and Immunology, Université de Montréal, Montréal, QC, Canada; Immunopathology Axis, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada., Iqbal Z; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK. Electronic address: zi@ebi.ac.uk.

Publikováno v: The Lancet. Microbe [Lancet Microbe] 2023 Feb; Vol. 4 (2), pp. e84-e92. Date of Electronic Publication: 2022 Dec 19.

Different PPD-stimulated cytokine responses from patients infected with genetically distinct Mycobacterium tuberculosis complex lineages.

Autor: Ranaivomanana P; Mycobacteria Unit, Institut Pasteur de Madagascar, B.P. Ambatofotsikely, Antananarivo, Madagascar., Rabodoarivelo MS; Mycobacteria Unit, Institut Pasteur de Madagascar, B.P. Ambatofotsikely, Antananarivo, Madagascar., Ndiaye MDB; Mycobacteria Unit, Institut Pasteur de Madagascar, B.P. Ambatofotsikely, Antananarivo, Madagascar., Rakotosamimanana N; Mycobacteria Unit, Institut Pasteur de Madagascar, B.P. Ambatofotsikely, Antananarivo, Madagascar. Electronic address: niaina@pasteur.mg., Rasolofo V; Mycobacteria Unit, Institut Pasteur de Madagascar, B.P. Ambatofotsikely, Antananarivo, Madagascar.

Publikováno v: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Mar; Vol. 104, pp. 725-731. Date of Electronic Publication: 2021 Feb 05.