MAMMAL -- Molecular Aligned Multi-Modal Architecture and Language

Autor: Shoshan, Yoel, Raboh, Moshiko, Ozery-Flato, Michal, Ratner, Vadim, Golts, Alex, Weber, Jeffrey K., Barkan, Ella, Rabinovici-Cohen, Simona, Polaczek, Sagi, Amos, Ido, Shapira, Ben, Hazan, Liam, Ninio, Matan, Ravid, Sivan, Danziger, Michael M., Morrone, Joseph A., Suryanarayanan, Parthasarathy, Rosen-Zvi, Michal, Hexter, Efrat

Drug discovery typically consists of multiple steps, including identifying a target protein key to a disease's etiology, validating that interacting with this target could prevent symptoms or cure the disease, discovering a small molecule or biologic

Externí odkaz: http://arxiv.org/abs/2410.22367

Clinical implications of head trauma in frontotemporal dementia and primary progressive aphasia

Autor: Breton M. Asken, Jessica M. Bove, Russell M. Bauer, Jeremy A. Tanner, Kaitlin B. Casaletto, Adam M. Staffaroni, Lawren VandeVrede, Michael L. Alosco, Jesse B. Mez, Robert A. Stern, Bruce L. Miller, Lea T. Grinberg, Adam L. Boxer, Maria Luisa Gorno-Tempini, Howie J. Rosen, Gil D. Rabinovici, Joel H. Kramer

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-10 (2024)

Abstract Background Traumatic brain injury (TBI) and repetitive head impacts (RHI) have been linked to increased risk for multiple types of neurodegenerative disease, higher dementia risk, and earlier age of dementia symptom onset, suggesting transdi

Externí odkaz: https://doaj.org/article/e6317e81cad640f78dcc0f579d63519a

Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis

Autor: Abdi, Zeinab, Agosta, Federica, Ahmed, Samrah, Alcolea, Daniel, Allen, Isabel Elaine, Allinson, Kieren S.J., Apostolova, Liana G., Arighi, Andrea, Balasa, Mircea, Barkhof, Frederik, Best, John, Boon, Baayla D., Brandt, Katherine D., Brosch, Jared, Burrell, James, Butler, Christopher R., Calandri, Ismael, Caminiti, Silvia Paola, Canu, Elisa, Carrillo, Maria C., Caso, Francesca, Chapleau, Marianne, Chrem Mendez, Patricio, Chu, Min, Crutch, Sebastian, Cordato, Nicholas, Costa, Ana Sofia, Cui, Yue, Dickerson, Bradford, Dickson, Dennis W., Duara, Ranjan, Dubois, Bruno, Eldaief, Mark, Farlow, Martin, Fenoglio, Chiara, Filippi, Massimo, Fliessbach, Klaus, Formaglio, Maïté, Fortea, Juan, Fox, Nick, Foxe, David, Tilikete, Caroline Froment, Frosch, Matthew P., Fumagalli, Giorgio Giulio, Galasko, Douglas, Galimberti, Daniela, Garat, Oscar, Giardinieri, Giulia, Graff-Radford, Jonathan, Graff-Radford, Neill R., Grinberg, Lea, Groot, Colin, Hake, Ann Marie, Hansson, Oskar, Headley, Alison, Hernandez, Micaela, Hochberg, Daisy, Hodges, John R., Hof, Patrick R., Holton, Janice, Hromas, Gabrielle, Gala, Ignacio Illán, Irwin, David J., Jaunmuktane, Zane, Jing, Donglai, Josephs, Keith, Kagerer, Sonja M., Kasuga, Kensaku, Kong, Yu, Kövari, Enikö, Lacombe-Thibault, Mégane, Lleó, Alberto, Laforce, Robert, La Joie, Renaud, Lashley, Tammaryn, Leger, Gabriel, Levin, Netta, Levy, Richard, Liu, Yang, Liu, Li, Lladó Plarrumaní, Albert, Lucente, Diane E., Machulda, Mary M., Magnani, Giuseppe, Magnin, Eloi, Malpetti, Maura, Matthews, Brandy, McGinnis, Scott, Mendez, Mario F., Mesulam, Marsel, Migliaccio, Raffaella, Miklitz, Carolin, Miller, Zachary A., Montembeault, Maxime, Murray, Melissa E., Mundada, Nidhi, Nemes, Sara, Nestor, Peter J., Ocal, Dilek, Ossenkoppele, Rik, Paterson, Ross, Pelak, Victoria, Perani, Daniela, Phillips, Jeffrey, Piguet, Olivier, Pijnenburg, Yolande, Putcha, Deepti, Quimby, Megan, Rabinovici, Gil D., Reetz, Kathrin, Rein, Netaniel, Revesz, Tamas, Rezaii, Neguine, Rodriguez-Porcel, Federico, Rogalski, Emily, Rowe, James B., Ryan, Natalie, Sanchez-Valle, Raquel, Sacchi, Luca, Santos-Santos, Miguel Ángel, Schott, Jonathan M., Seeley, William, Sherman, Janet, Spina, Salvatore, Stomrud, Erik, Sullivan, A. Campbell, Tanner, Jeremy, Tideman, Pontus, Tokutake, Takayoshi, Tondo, Giacomo, Touroutoglou, Alexandra, Tousi, Babak, Vandenberghe, Rik, van der Flier, Wiesje, Walker, Jamie M., Weintraub, Sandra, Whitwell, Jennifer L., Wolk, David A., Wong, Bonnie, Wu, Liyong, Xie, Kexin, Yong, Keir, Apostolova, Liana, Boon, Baayla D C, Grinberg, Lea T, Irwin, David J, Josephs, Keith A, Mendez, Mario F, Mendez, Patricio Chrem, Miller, Zachary A, Murray, Melissa E, Nemes, Sára, Schott, Jonathan M, Sullivan, A Campbell, Walker, Jamie, Whitwell, Jennifer L, Wolk, David A, Rabinovici, Gil D ^*

Publikováno v: In The Lancet Neurology February 2024 23(2):168-177

On the time dependence of holographic complexity for charged AdS black holes with scalar hair

Autor: Auzzi, Roberto, Bolognesi, Stefano, Rabinovici, Eliezer, Massolo, Fidel I. Schaposnik, Tallarita, Gianni

In the presence of a scalar hair perturbation, the Cauchy horizon of a Reissner-Nordstr\"om black hole disappears and is replaced by the rapid collapse of the Einstein-Rosen bridge, which leads to a Kasner singularity [1,2]. We study the time-depende

Externí odkaz: http://arxiv.org/abs/2205.03365

Krylov Localization and suppression of complexity

Autor: Rabinovici, E., Sánchez-Garrido, A., Shir, R., Sonner, J.

Quantum complexity, suitably defined, has been suggested as an important probe of late-time dynamics of black holes, particularly in the context of AdS/CFT. A notion of quantum complexity can be effectively captured by quantifying the spread of an op

Externí odkaz: http://arxiv.org/abs/2112.12128