Non-invasive imaging in experimental medicine for drug development

Autor: Matthews, Paul M, Rabiner, Ilan, Gunn, Roger

Publikováno v: In Current Opinion in Pharmacology 2011 11(5):501-507

Disturbances across whole brain networks during reward anticipation in an abstinent addiction population

Autor: Nestor, Liam J, Suckling, John, Ersche, Karen D, Murphy, Anna, McGonigle, John, Orban, Csaba, Paterson, Louise M, Reed, Laurence, Taylor, Eleanor, Flechais, Remy, Smith, Dana, Bullmore, Edward T, Elliott, Rebecca, Deakin, Bill, Rabiner, Ilan, Hughes, Anne-Lingford, Sahakian, Barbara J, Robbins, Trevor W, Nutt, David J, ICCAM Consortium

Publikováno v: NeuroImage : Clinical
NeuroImage: Clinical, Vol 27, Iss, Pp 102297-(2020)
ICCAM Consortium 2020, ' Disturbances across whole brain networks during reward anticipation in an abstinent addiction population ', NeuroImage. Clinical, vol. 27, pp. 102297 . https://doi.org/10.1016/j.nicl.2020.102297

Graphical abstract Network based statistics (NBS) analyses detected a graph sub-network comprising 153 edges between 59 nodes of the connectome where the ADD group demonstrated significantly less connectivity compared with the CON group. These differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90538b9ba22eef69676c232417e8471a
https://www.repository.cam.ac.uk/handle/1810/307013

Naltrexone differentially modulates the neural correlates of motor impulse control in abstinent alcohol-dependent and polysubstance-dependent individuals

Autor: Nestor, Liam J, Paterson, Louise M, Murphy, Anna, McGonigle, John, Orban, Csaba, Reed, Laurence, Taylor, Eleanor, Flechais, Remy, Smith, Dana, Bullmore, Edward T, Ersche, Karen D, Suckling, John, Elliott, Rebecca, Deakin, Bill, Rabiner, Ilan, Lingford Hughes, Anne, Sahakian, Barbara J, Robbins, Trevor W, Nutt, David J, ICCAM Consortium

Identifying key neural substrates in addiction disorders for targeted drug development remains a major challenge for clinical neuroscience. One emerging target is the opioid system, where substance-dependent populations demonstrate prefrontal opioid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdf0b8c57b1e755c34f0b2b7d471ca15

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