Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Rabindranath Tripathy"'
Autor:
Thomas J. Connors, Jie Qian, Zeck Huang, Joanne R. Mathiasen, Edward R. Bacon, Thelma S. Angeles, Mark J. Huffman, Emir Duzic, Joseph M. Salvino, Beth Ann McKenna, Hervé Schaffhauser, Robert J. McHugh, Lily D. Lu, George C. Morton, Beverly P. Holskin, Karla Kopec, Amy DiCamillo, Gerard C. Rosse, Chrysanthe Spais, Rabindranath Tripathy, Lisa D. Aimone
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1421-1426
Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine(6) (5-HT(6)) receptor antagonists show beneficial effect on cognition in several animal models. Based on a ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33e912dffb6b9ff1c34528c45a1f47ab
https://doi.org/10.1016/j.bmcl.2011.12.026
https://doi.org/10.1016/j.bmcl.2011.12.026
Autor:
Gregory J. Wells, Weihua Wan, Henry J. Breslin, Kevin J. Wells-Knecht, Bruce D. Dorsey, Mark A. Ator, Rabindranath Tripathy, Lisa D. Aimone, Mangeng Cheng, Ashley T. Wohler, Zeqi Huang, Tho V. Thieu, Thelma S. Angeles, Matthew R. Quail, Eugen F. Mesaros, Craig A. Zificsak, James Diebold, Jason C. Wagner, Gregory R. Ott, Lihui Lu, Robert J. McHugh, Mark S. Albom
Publikováno v:
Journal of Medicinal Chemistry. 55:115-125
Chemical strategies to mitigate cytochrome P450-mediated bioactivation of novel 2,7-disubstituted pyrrolo[2,1-f][1,2,4]triazine ALK inhibitors are described along with synthesis and biological activity. Piperidine-derived analogues showing minimal mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520de362a4a9d778605492e39225e966
https://doi.org/10.1021/jm2010767
https://doi.org/10.1021/jm2010767
Autor:
Rabindranath Tripathy, Reddy Dandu R, Jasbir Singh, John P. Mallamo, Mohamed Iqbal, Keith S. Learn
Publikováno v:
Tetrahedron Letters. 43:217-220
A modified core structure of indolo[2,3-a]carbazole template has been immobilized. EtMgBr was identified as a substrate compatible base providing solid-phase dianion formation. Depending upon the nature of the electrophile, the core structure has bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::840206a8d3314d8f38eb2aa38212b33c
https://doi.org/10.1016/s0040-4039(01)02140-2
https://doi.org/10.1016/s0040-4039(01)02140-2
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:2315-2319
A series of irreversible inhibitors of recombinant calpain has been synthesized and their rates of inactivation have been evaluated against calpain and cathepsin B, respectively. The design of the inhibitors was based on the quiescent affinity label
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51e852c2d7642f9ca18c7c2397a6766
https://doi.org/10.1016/s0960-894x(00)00451-0
https://doi.org/10.1016/s0960-894x(00)00451-0
Autor:
Sankar Chatterjee, Shobha E. Senadhi, Zi-Qiang Gu, Rabindranath Tripathy, Mark A. Ator, Derek Dunn
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2647-2652
The syntheses and biological activities of a series of calpain I inhibitors, derived from D- and L-Pro, are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43f1cb0bb6af11dcbdef487c34418f0
https://doi.org/10.1016/s0960-894x(98)00470-3
https://doi.org/10.1016/s0960-894x(98)00470-3
Autor:
Kurt A. Josef, Donna Bozyczko-Coyne, Zi-Qiang Gu, Sankar Chatterjee, Ming Tao, Rabindranath Tripathy, Ron Bihovsky, Mark A. Ator, Beth Ann McKenna, Shobha E. Senadhi, John P. Mallamo, Teresa M. O'Kane, Satish Mallya, Robert Siman, Derek Dunn
Publikováno v:
Journal of Medicinal Chemistry. 41:2663-2666
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602925a84b28f1f6315385e1e320e622
https://doi.org/10.1021/jm980035y
https://doi.org/10.1021/jm980035y
Autor:
Shobha E. Senadhi, Eric Griffith, Sheryl L. Meyer, Rabindranath Tripathy, William Biazzo, Sankar Chatterjee, Kurt A. Josef, Manoj Das, Bruce Dembofsky, Bethany Freed, Ming Tao, Patricia A. Messina, Robert Siman, Derek Dunn, Mark A. Ator, Ron Bihovsky, Mohamed Iqbal, Donna Bozyczko-Coyne
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:539-544
Dipeptide and tripeptide aldehydes have been evaluated as inhibitors of human calpain I. Dipeptide aldehydes are generally equipotent with tripeptide aldehydes. Calpain I possesses a rather stringent requirement for Leu at P2, but accepts a variety o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969c79285bb942274ed65d64259fb405
https://doi.org/10.1016/s0960-894x(97)00063-2
https://doi.org/10.1016/s0960-894x(97)00063-2
Autor:
Rabindranath, Tripathy, Robert J, McHugh, Edward R, Bacon, Joseph M, Salvino, George C, Morton, Lisa D, Aimone, Zeck, Huang, Joanne R, Mathiasen, Amy, DiCamillo, Mark J, Huffman, Beth A, McKenna, Karla, Kopec, Lily D, Lu, Jie, Qian, Thelma S, Angeles, Thomas, Connors, Chrysanthe, Spais, Beverly, Holskin, Emir, Duzic, Hervé, Schaffhauser, Gerard C, Rossé
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(3)
Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine(6) (5-HT(6)) receptor antagonists show beneficial effect on cognition in several animal models. Based on a ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbd67be491fa50904fc04fc20c374a04
https://pubmed.ncbi.nlm.nih.gov/22226656
https://pubmed.ncbi.nlm.nih.gov/22226656
Publikováno v:
ChemInform. 23
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ef7ab8b93246eaee4e96a62e5e44a68
https://doi.org/10.1002/chin.199201080
https://doi.org/10.1002/chin.199201080
Autor:
Ted L. Underiner, Matthew R. Quail, Lisa D. Aimone, Mangeng Cheng, Matthew A. Curry, Weihua Wan, Mark S. Albom, Bruce D. Dorsey, Thelma S. Angeles, Gregory R. Ott, Rabindranath Tripathy, Bruce Ruggeri, Robert J. McHugh, Andrew V. Anzalone, Mark A. Ator, Lihui Lu
Publikováno v:
ACS medicinal chemistry letters. 1(9)
A series of novel 7-amino-1,3,4,5-tetrahydrobenzo[b]azepin-2-one derivatives within the diaminopyrimidine class of kinase inhibitors were identified that target anaplastic lymphoma kinase (ALK). These inhibitors are potent against ALK in an isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e04e4a092f07a2a6992cf3ff994621b
https://pubmed.ncbi.nlm.nih.gov/24900237
https://pubmed.ncbi.nlm.nih.gov/24900237