TET2 regulates immune tolerance in chronically activated mast cells

Autor: Riccardo Rigo, Rabie Chelbi, Julie Agopian, Sebastien Letard, Aurélien Griffon, Hussein Ghamlouch, Julien Vernerey, Vasileios Ladopoulos, Edwige Voisset, Paulo De Sepulveda, Geoffrey Guittard, Jacques A. Nunès, Ghislain Bidaut, Berthold Göttgens, Michael Weber, Olivier A. Bernard, Patrice Dubreuil, Erinn Soucie

Publikováno v: JCI Insight, Vol 7, Iss 7 (2022)

Mutation of the TET2 DNA-hydroxymethylase has been associated with a number of immune pathologies. The disparity in phenotype and clinical presentation among these pathologies leads to questions regarding the role of TET2 mutation in promoting diseas

Externí odkaz: https://doaj.org/article/4730970c79894bdda7977a2e88bc7e6f

Dysfunction of exocytosis causes catecholamine hypersecretion in patient with pheochromocytoma

Autor: Sébastien Houy, Laura Streit, Ines Drissa, Marion Rame, Charles Decraene, Sophie Moog, Laurent Brunaud, Joël Lanoix, Rabie Chelbi, Florence Bihain, Stéphanie Lacomme, Sandra Lomazzi, Michel Vix, Didier Mutter, Eustache Paramithiotis, Christophe Dubessy, Nicolas Vitale, Stéphane Ory, Stéphane Gasman

Pheochromocytoma (Pheo) is a neuroendocrine tumor that develops from chromaffin cells of the adrenal medulla, and is responsible of an excess of catecholamines secretion leading to severe clinical symptoms such as hypertension, elevated stroke risk a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::38ac891537cb436a239075d28d475eae
https://doi.org/10.1101/2021.11.02.466874

The NF-κB pathway controls H3K9me3 levels at intronic LINE-1 elements and hematopoietic stem cell gene expression in cis

Autor: Yanis Pelinski, Donia Hidaoui, Anne Stolz, François Hermetet, Rabie Chelbi, M’boyba Khadija Diop, Amir M. Chioukh, Françoise Porteu, Emilie Elvira-Matelot

SUMMARYIonizing radiations (IR) alter hematopoietic stem cell (HSC) function on the long-term, but the mechanisms underlying these effects are still poorly understood. We recently showed that IR induces the derepression of L1Md, the mouse young subfa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60bc1411bc77fdb5fd458d9ae61b4ec3
https://doi.org/10.1101/2021.06.08.447574

The activation trajectory of plasmacytoid dendritic cells in vivo during a viral infection

Autor: Jean-Luc Davignon, Karima Naciri, Rabie Chelbi, Gilles Bessou, Chuang Dong, Nils Collinet, Michael Valente, Geoffray Brelurut, Pierre Milpied, Abdenour Abbas, Morgane Thomas-Chollier, Noudjoud Attaf, Thien-Phong Vu Manh, Inaki Cervera-Marzal, Alexandra-Chloé Villani, Benjamin Rauwel, Denis Thieffry, Marc Dalod, Elena Tomasello

Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2020, 21 (9), pp.983-997. ⟨10.1038/s41590-020-0731-4⟩
Nature Immunology, 2020, 21 (9), pp.983-997. ⟨10.1038/s41590-020-0731-4⟩
Nature immunology

International audience; Plasmacytoid dendritic cells (pDCs) are a major source of type I interferon (IFN-I). What other functions pDCs exert in vivo during viral infections is controversial, and more studies are needed to understand their orchestrati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd76519d3ec2c2f1de126656bc2665f9
https://hal.archives-ouvertes.fr/hal-02980944/file/2020_11_30_Abbas_et_al_2020_accepted_manuscript_for_HAL_small_size.pdf

Molecular dissection of plasmacytoid dendritic cell activation

Autor: Elena, Tomasello, Karima, Naciri, Rabie, Chelbi, Gilles, Bessou, Anissa, Fries, Elise, Gressier, Abdenour, Abbas, Emeline, Pollet, Philippe, Pierre, Toby, Lawrence, Thien-Phong, Vu Manh, Marc, Dalod

Publikováno v: The EMBO Journal

Plasmacytoid dendritic cells (pDC) are the major source of type I interferons (IFN‐I) during viral infections, in response to triggering of endosomal Toll‐like receptors (TLRs) 7 or 9 by viral single‐stranded RNA or unmethylated CpG DNA, respec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::45b7ad67e80dc694111dce09b6c3f079
https://pubmed.ncbi.nlm.nih.gov/30131424