Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated Aβ Is Induced by Pyroglutamate–Aβ Formation

Autor: Becker A, Jagla W, Steffen Rossner, von Hörsten S, Raber Ka, Bäuscher C, S. Schilling, Sedlmeier R, Alexander P. Osmand, H.-U. Demuth, Holger Cynis, Alexandru A, Graubner S, Kohlmann S, Hartlage-Rübsamen M, Petrasch-Parwez E, Raik Rönicke, Klaus G. Reymann, Waniek A

Publikováno v: The journal of neuroscience 31(36), 12790-12801 (2011). doi:10.1523/JNEUROSCI.1794-11.2011

Posttranslational amyloid-β (Aβ) modification is considered to play an important role in Alzheimer's disease (AD) etiology. An N-terminally modified Aβ species, pyroglutamate-amyloid-β (pE3–Aβ), has been described as a major constituent of Aβ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab8c8311fd466e25bc9dfdeef1f5c27
https://doi.org/10.1523/jneurosci.1794-11.2011

Early postnatal behavioral, cellular, and molecular changes in models of Huntington disease are reversible by HDAC inhibition.

Autor: Siebzehnrübl FA; McKnight Brain Institute, Department of Neurosurgery, University of Florida, Gainesville, FL 32611.; European Cancer Stem Cell Research Institute, Cardiff University School of Biosciences, Cardiff CF10 3AX, United Kingdom., Raber KA; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany., Urbach YK; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany., Schulze-Krebs A; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany., Canneva F; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany., Moceri S; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany., Habermeyer J; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany., Achoui D; McKnight Brain Institute, Department of Neurosurgery, University of Florida, Gainesville, FL 32611., Gupta B; European Cancer Stem Cell Research Institute, Cardiff University School of Biosciences, Cardiff CF10 3AX, United Kingdom., Steindler DA; McKnight Brain Institute, Department of Neurosurgery, University of Florida, Gainesville, FL 32611.; Neuroscience and Aging Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Medford, MA 02155., Stephan M; Clinic of Psychosomatic and Psychotherapy, Medical School Hannover, 30625 Hannover, Germany., Nguyen HP; Institute of Medical Genetics and Applied Genomics, Center for Rare Diseases, University of Tübingen, 72074 Tübingen, Germany., Bonin M; Institute of Medical Genetics and Applied Genomics, Center for Rare Diseases, University of Tübingen, 72074 Tübingen, Germany., Riess O; Institute of Medical Genetics and Applied Genomics, Center for Rare Diseases, University of Tübingen, 72074 Tübingen, Germany., Bauer A; Institute of Neuroscience and Medicine, Forschungszentrum Jülich, 52425 Jülich, Germany., Aigner L; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, 5020 Salzburg, Austria., Couillard-Despres S; Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria., Paucar MA; Section of Translational Neuropharmacology, Department of Physiology and Pharmacology, Karolinska Institute, 171 77 Solna, Sweden., Svenningsson P; Section of Translational Neuropharmacology, Department of Physiology and Pharmacology, Karolinska Institute, 171 77 Solna, Sweden., Osmand A; Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996., Andreew A; Institute for Human Genetics, Charité-Universitätsmedizin, 13353 Berlin, Germany., Zabel C; Institute for Human Genetics, Charité-Universitätsmedizin, 13353 Berlin, Germany., Weiss A; Neuroscience Discovery, Novartis Pharma AG, 4056 Basel, Switzerland., Kuhn R; Neuroscience Discovery, Novartis Pharma AG, 4056 Basel, Switzerland., Moussaoui S; Neuroscience Discovery, Novartis Pharma AG, 4056 Basel, Switzerland., Blockx I; Bio-Imaging Laboratory, University of Antwerp, 2000 Antwerp, Belgium., Van der Linden A; Bio-Imaging Laboratory, University of Antwerp, 2000 Antwerp, Belgium., Cheong RY; Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Roybon L; Stem Cell Laboratory for CNS Disease Modeling, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., Petersén Å; Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, 221 84 Lund, Sweden., von Hörsten S; Department of Experimental Therapy, Friedrich-Alexander-University, 91054 Erlangen, Germany; stephan.v.hoersten@fau.de.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Sep 11; Vol. 115 (37), pp. E8765-E8774. Date of Electronic Publication: 2018 Aug 27.

Automated phenotyping and advanced data mining exemplified in rats transgenic for Huntington's disease.

Autor: Urbach YK; Experimental Therapy, Preclinical Experimental Center, Universitätsklinikum Erlangen, 91054 Erlangen, Germany., Raber KA; Experimental Therapy, Preclinical Experimental Center, Universitätsklinikum Erlangen, 91054 Erlangen, Germany., Canneva F; Experimental Therapy, Preclinical Experimental Center, Universitätsklinikum Erlangen, 91054 Erlangen, Germany., Plank AC; Experimental Therapy, Preclinical Experimental Center, Universitätsklinikum Erlangen, 91054 Erlangen, Germany., Andreasson T; NeuroSearch Sweden AB, Arvid Wallgrens Backe 20, 41346 Gothenburg, Sweden., Ponten H; NeuroSearch Sweden AB, Arvid Wallgrens Backe 20, 41346 Gothenburg, Sweden., Kullingsjö J; NeuroSearch Sweden AB, Arvid Wallgrens Backe 20, 41346 Gothenburg, Sweden., Nguyen HP; Department of Medical Genetics, University of Tübingen, 72076 Tübingen, Germany., Riess O; Department of Medical Genetics, University of Tübingen, 72076 Tübingen, Germany., von Hörsten S; Experimental Therapy, Preclinical Experimental Center, Universitätsklinikum Erlangen, 91054 Erlangen, Germany. Electronic address: Stephan.v.Hoersten@uk-erlangen.dede.

Publikováno v: Journal of neuroscience methods [J Neurosci Methods] 2014 Aug 30; Vol. 234, pp. 38-53. Date of Electronic Publication: 2014 Jul 11.

Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.

Autor: Alexandru A; Ingenium Pharmaceuticals, 82152 Martinsried, Germany., Jagla W, Graubner S, Becker A, Bäuscher C, Kohlmann S, Sedlmeier R, Raber KA, Cynis H, Rönicke R, Reymann KG, Petrasch-Parwez E, Hartlage-Rübsamen M, Waniek A, Rossner S, Schilling S, Osmand AP, Demuth HU, von Hörsten S

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2011 Sep 07; Vol. 31 (36), pp. 12790-801.

Stem cell quiescence in the hippocampal neurogenic niche is associated with elevated transforming growth factor-beta signaling in an animal model of Huntington disease.

Autor: Kandasamy M; Institute of Molecular Regenerative Medicine, Paracelsus Medical University, Salzburg, Austria., Couillard-Despres S, Raber KA, Stephan M, Lehner B, Winner B, Kohl Z, Rivera FJ, Nguyen HP, Riess O, Bogdahn U, Winkler J, von Hörsten S, Aigner L

Publikováno v: Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2010 Jul; Vol. 69 (7), pp. 717-28.