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Synthesis and Antimicrobial Evaluation of New 1,2,4-Triazolo[1,5- a ]pyrimidine-Based Derivatives as Dual Inhibitors of Bacterial DNA Gyrase and DHFR.

Autor: Al-Wahaibi LH; Department of Chemistry, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia., Rabea SM; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Mahmoud MA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Youssif BGM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt., Bräse S; Institute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, Karlsruhe 76131, Germany., Abdel-Aziz SA; Department of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Boys), Al-Azhar University, Assiut 71524, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia 61519, Egypt.

Publikováno v: ACS omega [ACS Omega] 2024 Nov 11; Vol. 9 (47), pp. 47261-47273. Date of Electronic Publication: 2024 Nov 11 (Print Publication: 2024).

Synthesis of New Thiazole-Privileged Chalcones as Tubulin Polymerization Inhibitors with Potential Anticancer Activities.

Autor: Hashem H; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Sohag University, Sohag 82524, Egypt., Hassan A; Medicinal Chemistry Department, Faculty of Pharmacy, South Valley University, Qena 52242, Egypt.; Medicinal Chemistry Department, Clinical Pharmacy Program, South Valley National University, Qena 52242, Egypt., Abdelmagid WM; Medicinal Chemistry and Drug Discovery Research Centre, Swenam College, 210-6125 Sussex Avenue, Burnaby, BC V5H 4G1, Canada., Habib AGK; Department of Biotechnology and Life Sciences, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef 62521, Egypt., Abdel-Aal MAA; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt., Elshamsy AM; Medicinal Chemistry Department, Faculty of Pharmacy, Deraya University, New Minia 61768, Egypt., El Zawily A; Department of Plant and Microbiology, Faculty of Science, Damanhour University, Damanhour 22511, Egypt.; Division of Pharmaceutics and Translation Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA., Radwan IT; Supplementary General Sciences Department, Faculty of Oral and Dental Medicine, Future University in Egypt, Cairo 11835, Egypt., Bräse S; Institute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Kaiserstrasse 12, 76131 Karlsruhe, Germany., Abdel-Samea AS; Pharmacology and Toxicology Department, Faculty of Pharmacy, Deraya University, New Minia 61768, Egypt., Rabea SM; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.; Apogee Pharmaceuticals Inc., 4475 Wayburne Dr., Suite 105, Burnaby, BC V6V2H8, Canada.

Publikováno v: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2024 Aug 31; Vol. 17 (9). Date of Electronic Publication: 2024 Aug 31.

Synthesis and antimicrobial evaluation of new nitric oxide-donating fluoroquinolone/oxime hybrids.

Autor: Aziz HA; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt., Moustafa GAI; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt., Abuo-Rahma GEA; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt.; Department of Pharmaceutical Chemistry, Deraya University, New Minia, Minia, Egypt., Rabea SM; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt., Hauk G; Department of Biophysics and Biophysical Chemistry, School of Medicine, John Hopkins University, Baltimore, Maryland., Krishna VS; Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Hyderabad, India., Sriram D; Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Hyderabad, India., Berger JM; Department of Biophysics and Biophysical Chemistry, School of Medicine, John Hopkins University, Baltimore, Maryland., Abbas SH; Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt.

Publikováno v: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2021 Jan; Vol. 354 (1), pp. e2000180. Date of Electronic Publication: 2020 Sep 21.

Spirohydantoins and 1,2,4-triazole-3-carboxamide derivatives as inhibitors of histone deacetylase: Design, synthesis, and biological evaluation.

Autor: Aboeldahab AMA; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Beshr EAM; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Shoman ME; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt., Rabea SM; Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver BC V6T 1Z3, Canada., Aly OM; Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, Minia 61519, Egypt; College of Clinical Pharmacy, Albaha University, Saudi Arabia. Electronic address: omarsokkar@yahoo.com.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2018 Feb 25; Vol. 146, pp. 79-92. Date of Electronic Publication: 2018 Jan 12.