Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rabdan M. Tikhov"'
Autor:
Ekaterina A Glubokova, Irina A. Leneva, Nikolai Yu. Kuznetsov, Rabdan M. Tikhov, Nadezda P. Kartashova, Irina N. Falynskova
Publikováno v:
Acta Naturae
The World Health Organization (WHO) recommends antivirals as an additional line of defense against influenza. One of such drugs is rimantadine. However, most of the circulating strains of influenza A viruses are resistant to this drug. Thus, a search
Publikováno v:
Organic & Biomolecular Chemistry. 18:2793-2812
The current review summarizes the latest achievements in the synthesis of piperidine-2,4-dione-type azaheterocycles. Two main groups traditional (carbonyl compound transformations) and novel (anionic enolate rearrangements) of complementary methods f
Autor:
E.S. Kirillova, Ivan A. Godovikov, Nikolai Yu. Kuznetsov, Yuri N. Bubnov, Elena Burtseva, Konstantin A. Lyssenko, Michael G. Medvedev, Rabdan M. Tikhov
Publikováno v:
Organic & Biomolecular Chemistry. 15:3152-3157
A series of (R)- and (S)-isomers of new adamantane-substituted heterocycles (1,3-oxazinan-2-one, piperidine-2,4-dione, piperidine-2-one and piperidine) with potent activity against rimantadine-resistant strains of influenza A virus were synthesized t
Autor:
Yuri N. Bubnov, Nikolai Yu. Kuznetsov, Konstantin A. Lyssenko, Rabdan M. Tikhov, Tatyana V. Strelkova
Publikováno v:
Tetrahedron Letters. 57:4525-4528
A new and efficient method for the synthesis of 6-amino-2,3-dihydro-4-pyridinethiones from N -(3-butenyl)thioureas, without the use of conventional thiophosphorus reagents has been reported. Thioureas are initially transformed into iodocyclothiocarba
Publikováno v:
Organicbiomolecular chemistry. 16(39)
Dimethylamine adducts of triallyl-, triprenyl- and trans-cinnamyl(dipropyl)borane are effective reagents for mild homoallylation of primary amines with aqueous formaldehyde in MeOH without an inert atmosphere. A new concept is proposed for the explan
Publikováno v:
Organic letters. 20(12)
Triallylborane–amines adducts are effective stoichiometric allylating agents in the aminoallylation reaction of carbonyl compounds in methanol. Moreover, copper-catalyzed diastereoselective allylation of Ellman’s imine was achieved with triallylb
Publikováno v:
Organicbiomolecular chemistry. 14(18)
Three-step synthesis of 6-amino-2,3-dihydro-4-pyridinones from homoallylamines involving NBS-mediated cyclization of N-(3-butenyl)ureas to 6-(bromomethyl)-2-iminourethanes, dehydrohalogenation and a novel rearrangement as a key step has been develope