Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation.

Autor: Barone C; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., Orsenigo R; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., Cazzola A; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., D'Errico E; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., Patelli A; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., Quattrini G; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., Vergani B; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., Bombelli S; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., De Marco S; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., D'Orlando C; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., Bianchi C; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., Leone BE; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., Meneveri R; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., Biondi A; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.; Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy., Cazzaniga G; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.; Centro Tettamanti, IRCCS San Gerardo dei Tintori, 20900 Monza, Italy., Rabbitts TH; Division of Cancer Therapeutics, Institute of Cancer Research, 15 Cotswold Road, Sutton, London SM2 5NG, UK., Brunelli S; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy., Azzoni E; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.

Publikováno v: Cancers [Cancers (Basel)] 2023 Jul 14; Vol. 15 (14). Date of Electronic Publication: 2023 Jul 14.

Intracellular Antibodies for Drug Discovery and as Drugs of the Future.

Autor: Rabbitts TH; Institute of Cancer Research, Division of Cancer Therapeutics, 15 Cotswold Road, Sutton, London SM2 5NG, UK.

Publikováno v: Antibodies (Basel, Switzerland) [Antibodies (Basel)] 2023 Mar 16; Vol. 12 (1). Date of Electronic Publication: 2023 Mar 16.

Identification of a minority population of LMO2 ⁺ breast cancer cells that integrate into the vasculature and initiate metastasis.

Autor: Sikandar SS; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA., Gulati GS; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, School of Medicine, Stanford, CA 94305, USA., Antony J; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, School of Medicine, Stanford, CA 94305, USA., Fetter I; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA., Kuo AH; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, School of Medicine, Stanford, CA 94305, USA., Ho WHD; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, School of Medicine, Stanford, CA 94305, USA., Haro-Acosta V; Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA., Das S; Department of Biology, Stanford University, Stanford, CA 94305, USA., Steen CB; Division of Oncology, Department of Medicine, Stanford Cancer Institute, Stanford University, Stanford, CA, USA., Pereira TA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, School of Medicine, Stanford, CA 94305, USA., Qian D; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, School of Medicine, Stanford, CA 94305, USA., Beachy PA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, School of Medicine, Stanford, CA 94305, USA., Dirbas FM; Department of Surgery, Stanford Cancer Institute, Stanford University School of Medicine, 875 Blake Wilbur Drive, Rm CC2235, Stanford, CA 94305, USA., Red-Horse K; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, School of Medicine, Stanford, CA 94305, USA.; Department of Biology, Stanford University, Stanford, CA 94305, USA.; Howard Hughes Medical Institute, Stanford, CA 94305, USA., Rabbitts TH; Division of Cancer Therapeutics, Institute of Cancer Research, London SM2 5NG, UK., Thiery JP; Guangzhou Laboratory, International Biological Island, Guangzhou, Guangdong 510005, China., Newman AM; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, School of Medicine, Stanford, CA 94305, USA.; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA., Clarke MF; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, 265 Campus Drive, School of Medicine, Stanford, CA 94305, USA.; Department of Medicine, Stanford University, Stanford, CA 94305, USA.

Publikováno v: Science advances [Sci Adv] 2022 Nov 11; Vol. 8 (45), pp. eabm3548. Date of Electronic Publication: 2022 Nov 09.

A Cell-based Screening Method Using an Intracellular Antibody for Discovering Small Molecules Targeting Hard-to-drug Proteins.

Autor: Bery N; Cancer Research Centre of Toulouse, U1037 INSERM - Université Toulouse III Paul Sabatier - U5071 CNRS, 2 avenue Hubert Curien, Toulouse, France., Rabbitts TH; Institute of Cancer Research, Division of Cancer Therapeutics, 15 Cotswold Road, Sutton, London SM2 5NG, UK.

Publikováno v: Bio-protocol [Bio Protoc] 2022 Feb 20; Vol. 12 (4), pp. e4324. Date of Electronic Publication: 2022 Feb 20 (Print Publication: 2022).

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study.

Autor: Hastie KM; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Li H; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Bedinger D; Carterra, 825 N. 300 W. Ste C309, Salt Lake City, UT 84103, USA., Schendel SL; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Dennison SM; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA., Li K; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA., Rayaprolu V; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Yu X; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Mann C; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Zandonatti M; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Diaz Avalos R; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Zyla D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Buck T; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Hui S; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Shaffer K; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Hariharan C; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Yin J; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Olmedillas E; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Enriquez A; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Parekh D; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA., Abraha M; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA., Feeney E; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA., Horn GQ; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA., Aldon Y; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, Netherlands., Ali H; Quadrucept Bio, Ltd., Cambridge CB23 6DW, UK., Aracic S; Myrio Therapeutics Pty, Ltd., 1 Dalmore Drive, Scoresby, VIC 3179, Australia., Cobb RR; National Resilience, Inc., 13200 NW Nano Ct., Alachua, FL 32615, USA., Federman RS; Generate Biomedicines, Inc., 26 Landsdowne Street, Cambridge, MA 02139, USA., Fernandez JM; Activemotif, Inc., 1914 Palomar Oaks Way, Suite 150, Carlsbad, CA 92008, USA., Glanville J; Centivax, Inc., 201 Gateway Blvd., Floor 1, South San Francisco, CA 94080, USA., Green R; Generate Biomedicines, Inc., 26 Landsdowne Street, Cambridge, MA 02139, USA., Grigoryan G; Generate Biomedicines, Inc., 26 Landsdowne Street, Cambridge, MA 02139, USA., Lujan Hernandez AG; Twist Bioscience, 681 Gateway Blvd., South San Francisco, CA 94080, USA., Ho DD; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, 701 West 168th St., HHSC 1102, New York, NY 10032, USA., Huang KA; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital and Research Center for Emerging Viral Infections, Chang Gung University, Taoyuan, Taiwan., Ingraham J; Generate Biomedicines, Inc., 26 Landsdowne Street, Cambridge, MA 02139, USA., Jiang W; Shanghai Henlius Biotech, Inc., 9/F, Innov Tower, Zone A, no. 1801 Hongmei Road, Xuhui District, Shanghai, China., Kellam P; Kymab, Ltd., The Bennet Building, Babraham Research Campus, Cambridge CB22 3AT, UK.; Department of Infectious Disease, Imperial College, London SW7 2AZ, UK., Kim C; Celltrion, Inc., Department of Research and Development, 23 Academy-ro Yeonsu-gu Incheon, Republic of Korea., Kim M; Celltrion, Inc., Department of Research and Development, 23 Academy-ro Yeonsu-gu Incheon, Republic of Korea., Kim HM; Celltrion, Inc., Department of Research and Development, 23 Academy-ro Yeonsu-gu Incheon, Republic of Korea., Kong C; Sanyou Biopharmaceuticals Co., Ltd., no. 188 Xinjunhuan Road, Building 6B-C, 3rd Floor, Minhang District, Shanghai 201114, China., Krebs SJ; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA., Lan F; Activemotif, Inc., 1914 Palomar Oaks Way, Suite 150, Carlsbad, CA 92008, USA.; Shanghai Key Laboratory of Medical Epigenetics, International Laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, China., Lang G; Sanyou Biopharmaceuticals Co., Ltd., no. 188 Xinjunhuan Road, Building 6B-C, 3rd Floor, Minhang District, Shanghai 201114, China., Lee S; Celltrion, Inc., Department of Research and Development, 23 Academy-ro Yeonsu-gu Incheon, Republic of Korea., Leung CL; Generate Biomedicines, Inc., 26 Landsdowne Street, Cambridge, MA 02139, USA., Liu J; Shanghai Henlius Biotech, Inc., 9/F, Innov Tower, Zone A, no. 1801 Hongmei Road, Xuhui District, Shanghai, China., Lu Y; Activemotif, Inc., 1914 Palomar Oaks Way, Suite 150, Carlsbad, CA 92008, USA.; AbCipher Biotechnology, 188 Xinjun Ring Road, Building 2, 4th Floor, Minhang District, Shanghai 201114, China., MacCamy A; Fred Hutchinson Cancer Research Center, Vaccines and Infectious Diseases Division, Seattle, WA, USA., McGuire AT; Fred Hutchinson Cancer Research Center, Vaccines and Infectious Diseases Division, Seattle, WA, USA., Palser AL; Kymab, Ltd., The Bennet Building, Babraham Research Campus, Cambridge CB22 3AT, UK., Rabbitts TH; Quadrucept Bio, Ltd., Cambridge CB23 6DW, UK.; Institute of Cancer Research, Centre for Cancer Drug Discovery, London SM2 5NG, UK., Rikhtegaran Tehrani Z; Division of Clinical Care and Research, Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA., Sajadi MM; Division of Clinical Care and Research, Institute of Human Virology, University of Maryland, Baltimore, MD 21201, USA., Sanders RW; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, Netherlands., Sato AK; Twist Bioscience, 681 Gateway Blvd., South San Francisco, CA 94080, USA., Schweizer L; HiFiBiO, Inc., 237 Putnam Avenue, Cambridge, MA 02139, USA., Seo J; Celltrion, Inc., Department of Research and Development, 23 Academy-ro Yeonsu-gu Incheon, Republic of Korea., Shen B; HiFiBiO, Inc., 237 Putnam Avenue, Cambridge, MA 02139, USA., Snitselaar JL; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, Netherlands., Stamatatos L; Fred Hutchinson Cancer Research Center, Vaccines and Infectious Diseases Division, Seattle, WA, USA., Tan Y; Sanyou Biopharmaceuticals Co., Ltd., no. 188 Xinjunhuan Road, Building 6B-C, 3rd Floor, Minhang District, Shanghai 201114, China., Tomic MT; National Resilience, Inc., 2061 Challenger Dr., Alameda, CA 94501, USA., van Gils MJ; Department of Medical Microbiology and Infection Prevention, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Amsterdam Infection & Immunity Institute, 1105 AZ Amsterdam, Netherlands., Youssef S; Centivax, Inc., 201 Gateway Blvd., Floor 1, South San Francisco, CA 94080, USA., Yu J; Aaron Diamond AIDS Research Center, Columbia University Vagelos College of Physicians and Surgeons, 701 West 168th St., HHSC 1102, New York, NY 10032, USA., Yuan TZ; Twist Bioscience, 681 Gateway Blvd., South San Francisco, CA 94080, USA., Zhang Q; HiFiBiO, Inc., 237 Putnam Avenue, Cambridge, MA 02139, USA., Peters B; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.; Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA., Tomaras GD; Center for Human Systems Immunology, Departments of Surgery, Immunology, and Molecular Genetics and Microbiology and Duke Human Vaccine Institute, Duke University, Durham, NC 27701, USA., Germann T; Carterra, 825 N. 300 W. Ste C309, Salt Lake City, UT 84103, USA., Saphire EO; Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.; Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2021 Oct 22; Vol. 374 (6566), pp. 472-478. Date of Electronic Publication: 2021 Sep 23.