Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Rabbit test"'
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 32:651-656
Objectives Chitosan is a natural polysaccharide widely used in various clinical applications including regeneration of skin tissue. Aloe vera has properties in healing burns on the skin, anti-inflammatory effect, and leaves a protective layer on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25003d0815c0ae5ab83d1d9e82889ea5
https://doi.org/10.1515/jbcpp-2020-0407
https://doi.org/10.1515/jbcpp-2020-0407
Autor:
Amber B. Daniel, John P. Rooney, David Allen, Patricia Ceger, James F. Truax, Nicole Kleinstreuer, Neepa Choksi
Publikováno v:
Regul Toxicol Pharmacol
The in vivo rabbit test is the benchmark against which new approach methodologies for skin irritation are usually compared. No alternative method offers a complete replacement of animal use for this endpoint for all regulatory applications. Variabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6aaeaf10ae6bdcdfb1519bfde2713c4
https://pubmed.ncbi.nlm.nih.gov/33757807
https://pubmed.ncbi.nlm.nih.gov/33757807
Autor:
Kelly P Coleman, Chenghu Liu, Jia Liu, Wim H. de Jong, Chunguang Fan, Audrey P. Turley, Thor S. Rollins, Joseph W. Carraway
The ISO 10993 standards on biocompatibility assessment of medical devices discourage the use of animal tests when reliable and validated in vitro methods are available. A round robin validation study of in vitro reconstructed human epidermis (RhE) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5710a9f8633b162c61eb8d846c59ba54
http://hdl.handle.net/10029/624385
http://hdl.handle.net/10029/624385
Fever is a systemic inflammatory response of the body to pyrogens. Nuclear factor κB (NF-κB) is a central signalling molecule that causes the excessive secretion of various proinflammatory factors induced by pyrogens. This study explored the feasib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee24a761e0900e886203d13315f0d808
https://doi.org/10.1101/613190
https://doi.org/10.1101/613190
Autor:
Stefan Fennrich, Christian Schlensak, Hans Peter Wendel, Sandra Stoppelkamp, Leila Toliashvili, Ulrike Hennig
Publikováno v:
Alternatives to Laboratory Animals. 44:239-253
In the quality assurance of medical products, tests for sterility are essential. For parenteral pharmaceuticals, avoiding the presence of pyrogens is crucial. These fever-inducing substances (endotoxins and non-endotoxins) are not eliminated by stand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb516304ca6511d3cd3ba2b18314d305
https://doi.org/10.1177/026119291604400305
https://doi.org/10.1177/026119291604400305
Autor:
Rebecca Rose
Culture supernates from two strains of fL. coll were placed into different ligated intestinal sections (loops) of each animal. The two bacterial strains were identical except that one contained a plasmid carrying the heat-stable toxin b (STb) gene, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c90b1b4f6eabfefa63f19b0b2dced6a
https://doi.org/10.31274/rtd-180813-12933
https://doi.org/10.31274/rtd-180813-12933
Autor:
Robert G. Ellis-Hutchings, Reza J. Rasoulpour, Valerie A. Marshall, Edward W. Carney, Claire Terry, Keith J. Brooks, Shakil A. Saghir, Alene A. McCoy, Bethany R. Hannas, David L. Eisenbrandt, Richard Billington
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 154(1)
Dietary administration is a relevant route of oral exposure for regulatory toxicity studies of agrochemicals as it mimics potential human intake of the chemical via treated crops and commodities. Moreover, dietary administration of test compounds dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c584869de7ee89196945fb9404042fcf
https://pubmed.ncbi.nlm.nih.gov/27492223
https://pubmed.ncbi.nlm.nih.gov/27492223
Autor:
Jung Hee Yoon, Yirang Na, Eun Young Cho, Kyung Min Lim, Byeong Cheol Kang, Quan Hailian, Jun Won Yun, Seung Jin Bae, Miri Lee, Seung Hyeok Seok, Da eun Kim
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 37
In an effort to explore the use of alternative methods to animal testing for the evaluation of the ocular irritancy of medical devices, we evaluated representative contact lenses with the bovine corneal opacity and permeability test (BCOP) and an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d642042b604375d4e24f4bcfdeba503c
https://pubmed.ncbi.nlm.nih.gov/27596521
https://pubmed.ncbi.nlm.nih.gov/27596521
Publikováno v:
Toxicology in Vitro. 25:1912-1918
In this study, we examined the capacity of the Porcine Corneal Ocular Reversibility Assay (PorCORA) to classify the reversibility of ocular effects for 32 test compounds (20 reversible, 12 irreversible) from various chemical classes. PorCORA predicte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2982e464efc67926998ccb2dc0ab171
https://doi.org/10.1016/j.tiv.2011.06.008
https://doi.org/10.1016/j.tiv.2011.06.008
Autor:
Adenike Temidayo Oladiji, Musa Toyin Yakubu, O. B. Oloyede, Musa Oyewole Salawu, N. O. Muhammad
Publikováno v:
Pharmaceutical Biology. 49:1029-1033
Archachatina marginata Swainson (Achatinidae) is found in Nigeria, West Africa. Its hemolymph is applied as a disinfectant to blades and fresh cuts of circumcision in Yorubaland. The hemolymph is also used in traditional medicine practice. Investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b3e97fa76a55887465bdbef102f0c3
https://doi.org/10.3109/13880209.2011.560952
https://doi.org/10.3109/13880209.2011.560952