Collagen cross-linking impact on keratoconus extracellular matrix.

Autor: Rabab Sharif, Ben Fowler, Dimitrios Karamichos

Publikováno v: PLoS ONE, Vol 13, Iss 7, p e0200704 (2018)

BACKGROUND:Keratoconus (KC) is a common multifactorial ectatic corneal disease with unknown onset. KC most commonly appears in adolescence and affects approximately 1:400 people worldwide. Treatment options, for advanced KC cases, are collagen cross-

Externí odkaz: https://doaj.org/article/5c8e21cb2c2349d88df0ebb6c3bc5e12

Transcriptional profiling of corneal stromal cells derived from patients with keratoconus

Autor: Dimitrios Karamichos, Tina B. McKay, Rabab Sharif, Yutao Liu, Mariam Lotfy Khaled

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports

Keratoconus (KC) is a multi-factorial corneal ectasia with unknown etiology affecting approximately 1:2000 people worldwide. Dysregulated gene expression, using RNA-Seq technology, have been reported in KC corneal tissue. However, the differential ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726f80028a7d8131d76628f414f9b4ea
http://link.springer.com/article/10.1038/s41598-019-48983-8

Prolactin-Induced Protein is a Novel Biomarker for Keratoconus

Autor: Jesper Hjortdal, Kai Ding, Henrik Sejersen, Dimitrios Karamichos, Rabab Sharif, Sashia Bak-Nielsen

Publikováno v: Sharif, R, Bak-Nielsen, S, Sejersen, H, Ding, K, Hjortdal, J & Karamichos, D 2019, ' Prolactin-Induced Protein is a novel biomarker for Keratoconus ', Experimental Eye Research, vol. 179, pp. 55-63 . https://doi.org/10.1016/j.exer.2018.10.015

PURPOSE: The purpose of the study was to investigate the role of Prolactin-Induced Protein (PIP) as a predictive biomarker for Keratoconus (KC).PARTICIPANTS: This study included one hundred and forty-seven patients with KC (105 male, 42 female), and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97099a8464cf157142af5ba68e279e4
https://europepmc.org/articles/PMC6360109/

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

Autor: Dimitrios Karamichos, Jesper Hjortdal, Sashia Bak-Nielsen, Rabab Sharif

Publikováno v: Sharif, R, Bak-Nielsen, S, Hjortdal, J & Karamichos, D 2018, ' Pathogenesis of Keratoconus : The intriguing therapeutic potential of Prolactin-inducible protein ', Progress in Retinal and Eye Research, vol. 67, pp. 150-167 . https://doi.org/10.1016/j.preteyeres.2018.05.002

Keratoconus (KC) is the most common ectatic corneal disease, with clinical findings that include discomfort, visual disturbance and possible blindness if left untreated. KC affects approximately 1:400 to 1:2000 people worldwide, including both males

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b753cb2a0761d80783ce61a24a74cac
https://pubmed.ncbi.nlm.nih.gov/29758268

Corneal Tissue Engineering: An In Vitro Model of the Stromal-nerve Interactions of the Human Cornea

Autor: Dimitrios Karamichos, Tyler G. Rowsey, Shrestha Priyadarsini, Jian Xing Ma, Rabab Sharif

Publikováno v: Journal of Visualized Experiments.

Tissue engineering has gained substantial recognition due to the high demand for human cornea replacements with an estimated 10 million people worldwide suffering from corneal vision loss1. To address the demand for viable human corneas, significant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce6088b2bdc3596ab453b56c2361e70
https://doi.org/10.3791/56308