Rab5c promotes RSV and ADV replication by autophagy in respiratory epithelial cells

Autor: Xiuli Wang, Jing Cheng, Linchao Shen, Meixi Chen, Keran Sun, Jian Li, Miao Li, Cuiqing Ma, Lin Wei

Publikováno v: Virus Research, Vol 341, Iss , Pp 199324- (2024)

Respiratory system diseases caused by respiratory viruses are common and exert tremendous pressure on global healthcare system. In our previous studies, we found that Long non-coding RNA NRAV (Lnc NRAV) and its target molecule Rab5c plays a significa

Externí odkaz: https://doaj.org/article/d6d9c97e825a4bd195d6cf55d9930d0d

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ERN1 modifies the effect of glutamine deprivation on tumor growth related factors expression in U87 glioma cells

Autor: O. H. Minchenko, A. P. Kharkova, O. S. Hnatiuk, O. Y. Luzina, I. V. Kryvdiuk, A. Y. Kuznetsova

Publikováno v: The Ukrainian Biochemical Journal, Vol 90, Iss 3, Pp 49-61 (2018)

The expression of a subset of genes encoding important tumor growth related factors in U87 glioma cells with ERN1 (endoplasmic reticulum to nucleus signaling 1) loss of function as well as upon glutamine deprivation was studied. It was shown that glu

Externí odkaz: https://doaj.org/article/32c722cdca814fc4a7034a1a907a38d0

The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis

Autor: Wiebke Herzog, Lanette Kempers, Dirk de Korte, Iris M. De Cuyper, Ivo van der Bijl, Aldo Jongejan, Yuki Wakayama, Antonius L. van Boxtel, Marije Kat, Marvin Hubert, Anne-Marieke D. van Stalborch, Charita Furumaya, Coert Margadant, Dirk Geerts, Jaap D. van Buul

Publikováno v: Angiogenesis
Angiogenesis, 24(3), 695-714. Springer Netherlands
Kempers, L, Wakayama, Y, van der Bijl, I, Furumaya, C, de Cuyper, I M, Jongejan, A, Kat, M, van Stalborch, A-M D, van Boxtel, A L, Hubert, M, Geerts, D, van Buul, J D, de Korte, D, Herzog, W & Margadant, C 2021, ' The endosomal RIN2/Rab5C machinery prevents VEGFR2 degradation to control gene expression and tip cell identity during angiogenesis ', Angiogenesis, vol. 24, no. 3, pp. 695-714 . https://doi.org/10.1007/s10456-021-09788-4, https://doi.org/10.1007/s10456-021-09788-4

Sprouting angiogenesis is key to many pathophysiological conditions, and is strongly regulated by vascular endothelial growth factor (VEGF) signaling through VEGF receptor 2 (VEGFR2). Here we report that the early endosomal GTPase Rab5C and its activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeac18f57f69b93f205e720a01defc96
http://europepmc.org/articles/PMC8292304

MiR-145 functions as a tumor suppressor in Papillary Thyroid Cancer by inhibiting RAB5C

Autor: Xudong Zhao, Tianshu Li, Wenyue Ji, Ting Liu, Wei Zhang

Publikováno v: International Journal of Medical Sciences

Papillary thyroid carcinoma (PTC) accounts for the largest proportion of thyroid cancers; and its morbidity rate has dramatically increased in recent decades. However, the pathogenesis mechanisms of PTC are still not clear. This study aimed to reveal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea4bda5b8d206f68b5324e1c0c531a4b
http://europepmc.org/articles/PMC7415399