Výsledky vyhledávání - "Rab geranylgeranyltransferase"

Akademický článek

Rational design, optimization, and biological evaluation of novel α-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase

Autor: Joanna Małolepsza, Aleksandra Marchwicka, Remigiusz A. Serwa, Sanna P. Niinivehmas, Olli T. Pentikäinen, Edyta Gendaszewska-Darmach, Katarzyna M. Błażewska

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 940-951 (2022)

Rab geranylgeranyltransferase (GGTase-II, RGGT) catalyses the post-translational modification of eukaryotic Rab GTPases, proteins implicated in several pathologies, including cancer, diabetes, neurodegenerative, and infectious diseases. Thus, RGGT in

Externí odkaz: https://doaj.org/article/47e9fe0a13f242da98a9cbc1518f4bee

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Akademický článek

Rab Geranylgeranyltransferase Subunit Beta as a Potential Indicator to Assess the Progression of Amyotrophic Lateral Sclerosis

Autor: Jing Yang, Cheng Xin, Jia Huo, Xin Li, Hui Dong, Qi Liu, Rui Li, Yaling Liu

Publikováno v: Brain Sciences, Vol 13, Iss 11, p 1531 (2023)

Background: Currently, there is no effective treatment for amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disorder. Many biomarkers have been proposed, but because ALS is a clinically heterogeneous disease with an unclear etiolo

Externí odkaz: https://doaj.org/article/cfbaf1a44c48493ba8b23bdce910b552

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Akademický článek

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Double prenylation of SNARE protein Ykt6 is required for lysosomal hydrolase trafficking

Autor: Natsumi Sakata, Duc Anh Trinh, Ryutaro Shirakawa, Hisanori Horiuchi, Kota Goto

Publikováno v: The Journal of Biochemistry. 169:363-370

Ykt6 is an evolutionarily conserved SNARE protein regulating Golgi membrane fusion and other diverse membrane trafficking pathways. Unlike most SNARE proteins, Ykt6 lacks a transmembrane domain but instead has a tandem cysteine motif at the C-terminu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a547746ea417910b2bcf2445335ded8
https://doi.org/10.1093/jb/mvaa111

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Akademický článek

Geranylgeranylated Rab Proteins Terminating in Cys-Ala-Cys, but not Cys-Cys, are Carboxyl-Methylated by Bovine Brain Membranes in vitro

Autor: Smeland, Tor E., Seabra, Miguel C., Goldstein, Joseph L., Brown, Michael S.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 1994 Oct . 91(22), 10712-10716.

Externí odkaz: https://www.jstor.org/stable/2366100

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Molecular Characterization and Identification of Target Protein of an Important Vesicle Trafficking GeneAlRab7from a Salt Excreting HalophyteAeluropus lagopoides

Autor: Jackson Khedia, Khantika Patel, Navya Rajan, Parinita Agarwal, Pradeep K. Agarwal, Payal Sanadhya

Publikováno v: DNA and Cell Biology. 34:83-91

The endomembrane system plays an important role during cellular adaptation of the plants with the extracellular environment. The small GTP-binding protein Rab7 located at the vacuolar membrane regulates the vesicle fusion with the vacuole and thereby

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb2aedbf348d88a4ec9767430cf7591
https://doi.org/10.1089/dna.2014.2592

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Novel functions for Rab GTPases in multiple aspects of tumour progression

Autor: Miguel C. Seabra, Chiara Recchi

Publikováno v: Biochemical Society Transactions

Rab GTPases are master regulators of intracellular trafficking and, in recent years, their role in the control of different aspects of tumour progression has emerged. In the present review, we show that Rab GTPases are disregulated in many cancers an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3570f85248211e166585cad0524715a2
https://doi.org/10.1042/bst20120199

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Regulation of β2-Adrenergic Receptor Maturation and Anterograde Trafficking by an Interaction with Rab Geranylgeranyltransferase

Autor: Pascale Germain, Andréane Cartier, Véronik Lachance, Samuel Génier, Pascale Labrecque, Sandra Munger, Jean-Luc Parent

Publikováno v: Journal of Biological Chemistry. 286:40802-40813

Previous reports by us and others demonstrated that G protein-coupled receptors interact functionally with Rab GTPases. Here, we show that the β2-adrenergic receptor (β2AR) interacts with the Rab geranylgeranyltransferase α-subunit (RGGTA). Confoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48630ba4c308978f0cd2f1846487e115
https://doi.org/10.1074/jbc.m111.267815

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Inhibitors of Protein Geranylgeranyltransferase I and Rab Geranylgeranyltransferase Identified from a Library of Allenoate-derived Compounds

Autor: Lai Chan, Ohyun Kwon, Fuyuhiko Tamanoi, Hannah D. G. Fiji, Lea Guo, Masaru Watanabe, Dennis J. Slamon, Sape S. Kinderman

Publikováno v: Journal of Biological Chemistry. 283:9571-9579

Protein geranylgeranylation is critical for the function of a number of proteins such as RhoA, Rac, and Rab. Protein geranylgeranyltransferase I (GGTase-I) and Rab geranylgeranyltransferase (RabGGTase) catalyze these modifications. In this work, we f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ab3e031d2e40ffb6ce98d57802b5b6
https://doi.org/10.1074/jbc.m706229200

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