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Cutaneous Mitochondrial PO2, but Not Tissue Oxygen Saturation, Is an Early Indicator of the Physiologic Limit of Hemodilution in the Pig.

Autor: Römers LH; From the Department of Anesthesiology, Laboratory of Experimental Anesthesiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands (L.H.L.R., C.B., N.D., N.J.H.R., T.J., R.J.S., E.G.M.); Department of Anesthesiology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands (S.E.H.); and Department of Intensive Care, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands (A.L.)., Bakker C, Dollée N, Hoeks SE, Lima A, Raat NJ, Johannes T, Stolker RJ, Mik EG

Publikováno v: Anesthesiology [Anesthesiology] 2016 Jul; Vol. 125 (1), pp. 124-32.

Non-invasive monitoring of mitochondrial oxygenation and respiration in critical illness using a novel technique.

Autor: Harms FA; Department of Anesthesiology, Laboratory of Experimental Anesthesiology, Erasmus University Medical Center Rotterdam, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. f.harms@erasmusmc.nl., Bodmer SI; Department of Anesthesiology, Laboratory of Experimental Anesthesiology, Erasmus University Medical Center Rotterdam, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. s.bodmer@erasmusmc.nl., Raat NJ; Department of Anesthesiology, Laboratory of Experimental Anesthesiology, Erasmus University Medical Center Rotterdam, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. n.raat@erasmusmc.nl., Mik EG; Department of Anesthesiology, Laboratory of Experimental Anesthesiology, Erasmus University Medical Center Rotterdam, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. e.mik@erasmusmc.nl.; Department of Intensive Care, Erasmus University Medical Center Rotterdam, 's-Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. e.mik@erasmusmc.nl.

Publikováno v: Critical care (London, England) [Crit Care] 2015 Sep 22; Vol. 19, pp. 343. Date of Electronic Publication: 2015 Sep 22.

Direct sGC activation bypasses NO scavenging reactions of intravascular free oxy-hemoglobin and limits vasoconstriction.

Autor: Raat NJ; 1 Laboratory of Experimental Anesthesiology, Department of Anesthesiology, Erasmus MC-University Medical Center Rotterdam , Rotterdam, The Netherlands ., Tabima DM, Specht PA, Tejero J, Champion HC, Kim-Shapiro DB, Baust J, Mik EG, Hildesheim M, Stasch JP, Becker EM, Truebel H, Gladwin MT

Publikováno v: Antioxidants & redox signaling [Antioxid Redox Signal] 2013 Dec 20; Vol. 19 (18), pp. 2232-43. Date of Electronic Publication: 2013 Jul 09.

Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin.

Autor: Solomon SB; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: ssolomon@cc.nih.gov., Bellavia L; Department of Physics., Sweeney D; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA., Piknova B; Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Perlegas A; Department of Physics., Helms CC; Department of Physics; Translational Science Center, Wake Forest University, Winston-Salem, NC 27109, USA., Ferreyra GA; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA., Bruce King S; Department of Chemistry., Raat NJ; Vascular Medicine Institute; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Kern SJ; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA., Sun J; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA., McPhail LC; Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA., Schechter AN; Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA., Natanson C; Critical Care Medicine Department, National Institutes of Health, Bethesda, MD 20892, USA., Gladwin MT; Vascular Medicine Institute; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA., Kim-Shapiro DB; Department of Physics; Translational Science Center, Wake Forest University, Winston-Salem, NC 27109, USA. Electronic address: shapiro@wfu.edu.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2012 Dec 15; Vol. 53 (12), pp. 2229-39. Date of Electronic Publication: 2012 Oct 23.