Výsledky vyhledávání - "Raaij, M.J. van"

Inverted analogs of the antibiotic gramicidin S with an improved biological profile

Autor: Kapoerchan, V.V., Knijnenburg, A.D., Keizer, P., Spalburg, E., Neeling, A.J. de, Mars-Groenendijk, R.H., Noort, D., Otero, J.M., Llamas-Saiz, A.L., Raaij, M.J. van, Marel, G.A. van der, Overkleeft, H.S., Overhand, M.

Publikováno v: Bioorganic and Medicinal Chemistry, 20, 20, 6059-6062

A series of gramicidin S derivatives 4-15 are presented that have four ornithine residues as polar protonated side chains and two central hydrophobic amino acids with unaltered turn regions. These peptides were screened against human erthrocytes and

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Exploring the conformational and biological versatility of ß-turn-modified gramicidin s by using sugar amino acid homologues that vary in ring size

Autor: Knijnenburg, A.D., Tuin, A.W., Spalburg, E., Neeling, A.J. de, Mars-Groenendijk, R.H., Noort, D., Otero, J.M., Llamas-Saiz, A.L., Raaij, M.J. van, Marel, G.A. van der, Overkleeft, H.S., Overhand, M.

Publikováno v: Chemistry-A European Journal, 14, 17, 3995-4004

Monobenzylated sugar amino acids (SAAs) that differ in ether ring size (containing an oxetane, furanoid, and pyranoid ring) were synthesized and incorporated in one of the ß-turn regions of the cyclo-decapeptide gramicidin S (GS). CD, NMR spectrosco

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Evaluation of readily accessible azoles as mimics of the aromatic ring of D-phenylalanine in the turn region of gramicidin S

Autor: Knaap, M. van der, Lageveen, L.T., Busscher, H.J., Mars-Groenendijk, R., Noort, D., Otero, J.M., Llamas-Saiz, A.L., Raaij, M.J. van, Marel, G.A. van der, Overkleeft, H.S., Overhand, M.

Publikováno v: ChemMedChem, 5, 6, 840-847

The influence of replacing the d-phenylalanine residue with substituted and unsubstituted azoles on the structure and biological activity of the antibiotic gramicidinS was investigated against a representative panel of Gram-positive and Gram-negative

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Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified d-phenylalanine residues

Autor: Knaap, M. van der, Engels, E., Busscher, H.J., Otero, J.M., Llamas-Saiz, A.L., Raaij, M.J. van, Mars-Groenendijk, R.H., Noort, D., Marel, G.A. van der, Overkleeft, H.S., Overhand, M.

Publikováno v: Bioorganic and Medicinal Chemistry, 17, 17, 6318-6328

The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified d-phenylalanine residue, their antibacterial properties against several Gram positive and negative strains, as well as their hemolytic activity is re

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