Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Raad Z. Gharaibeh"'
Autor:
Megan M. Knuth, Jing Xue, Marwa Elnagheeb, Raad Z. Gharaibeh, Sarah A. Schoenrock, Susan McRitchie, Cory Brouwer, Susan J. Sumner, Lisa Tarantino, William Valdar, R. Scott Rector, Jeremy M. Simon, Folami Ideraabdullah
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionEmerging data suggests liver disease may be initiated during development when there is high genome plasticity and the molecular pathways supporting liver function are being developed.MethodsHere, we leveraged our Collaborative Cross mouse
Externí odkaz:
https://doaj.org/article/8293d185b25b4bafb987226841c7403f
Autor:
Michael W. Dougherty, Rafael Valdés-Mas, Kevin M. Wernke, Raad Z. Gharaibeh, Ye Yang, Jason O. Brant, Alberto Riva, Marcus Muehlbauer, Eran Elinav, Jens Puschhof, Seth B. Herzon, Christian Jobin
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 43, Iss , Pp 100918- (2023)
Certain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as “pks” encoding the biosynthesis of a secondary metabolite, colibactin. Colibactin-producing E. coli promote colorectal cancer (CRC) in preclinical models,
Externí odkaz:
https://doaj.org/article/be1c3e9769744513b42cb4dbc20b7f19
Autor:
Pyoung Hwa Park, Kelsey Keith, Gennaro Calendo, Jaroslav Jelinek, Jozef Madzo, Raad Z. Gharaibeh, Jayashri Ghosh, Carmen Sapienza, Christian Jobin, Jean-Pierre J. Issa
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
The intestinal microbiota is an important environmental factor implicated in CRC development. Intriguingly, modulation of DNA methylation by gut microbiota has been reported in preclinical models, although the relationship between tumor-infiltrating
Externí odkaz:
https://doaj.org/article/2856375f622b4bc5bda4e07109ea89fe
Autor:
Lais da Silva, Jinmai Jiang, Corey Perkins, Kalina Rosenova Atanasova, Julie K. Bray, Gamze Bulut, Ana Azevedo-Pouly, Martha Campbell-Thompson, Xiaozhi Yang, Hesamedin Hakimjavadi, Srikar Chamala, Ranjala Ratnayake, Raad Z. Gharaibeh, Chenglong Li, Hendrik Luesch, Thomas D. Schmittgen
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract Pancreatic acinar cells display a remarkable degree of plasticity and can dedifferentiate into ductal-like progenitor cells by a process known as acinar ductal metaplasia (ADM). ADM is believed to be one of the earliest precursor lesions tow
Externí odkaz:
https://doaj.org/article/7f68709dca8b439d9401f8575221c64b
Autor:
Rachel C. Newsome, Raad Z. Gharaibeh, Christine M. Pierce, Wildson Vieira da Silva, Shirlene Paul, Stephanie R. Hogue, Qin Yu, Scott Antonia, Jose R. Conejo-Garcia, Lary A. Robinson, Christian Jobin
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-15 (2022)
Abstract Background Recent studies show that human gut microbial composition can determine whether a patient is a responder or non-responder to immunotherapy but have not identified a common microbial signal shared by responding patients. The functio
Externí odkaz:
https://doaj.org/article/91a0ce6cc50b4f098348471265ee7dcd
Autor:
Qin Yu, Rachel C. Newsome, Mark Beveridge, Maria C. Hernandez, Raad Z. Gharaibeh, Christian Jobin, Ryan M. Thomas
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Preclinical data demonstrate that the gut microbiota can promote pancreatic ductal adenocarcinoma (PDAC), but mechanisms remain unclear. We hypothesized that intestinal microbiota alters anti-tumor innate immunity response to facilitate PDAC progress
Externí odkaz:
https://doaj.org/article/2858803b71ee4d7daa38553db53e6d16
Autor:
Michael W. Dougherty, Oleksandr Kudin, Marcus Mühlbauer, Josef Neu, Raad Z. Gharaibeh, Christian Jobin
Publikováno v:
BMC Microbiology, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background The intestinal tract undergoes a period of cellular maturation during early life, primarily characterized by the organization of epithelial cells into specialized crypt and villus structures. These processes are in part mediated b
Externí odkaz:
https://doaj.org/article/e3219e0331bc4019a9651c0c86259f14
Autor:
Melissa Ellermann, Raad Z. Gharaibeh, Nitsan Maharshak, Ernesto Peréz-Chanona, Christian Jobin, Ian M. Carroll, Janelle C. Arthur, Scott E Plevy, Anthony A. Fodor, Cory R. Brouwer, R. Balfour Sartor
Publikováno v:
Gut Microbes, Vol 11, Iss 1, Pp 32-50 (2020)
Iron deficiency, a common comorbidity of gastrointestinal inflammatory disorders such as inflammatory bowel diseases (IBD), is often treated with oral iron supplementation. However, the safety of oral iron supplementation remains controversial becaus
Externí odkaz:
https://doaj.org/article/1fdb8904e67b42ca83844eca09989e6a
Autor:
Quran Wu, James O’Malley, Susmita Datta, Raad Z. Gharaibeh, Christian Jobin, Margaret R. Karagas, Modupe O. Coker, Anne G. Hoen, Brock C. Christensen, Juliette C. Madan, Zhigang Li
Publikováno v:
Genes, Vol 13, Iss 6, p 1049 (2022)
Background: The human microbiome can contribute to pathogeneses of many complex diseases by mediating disease-leading causal pathways. However, standard mediation analysis methods are not adequate to analyze the microbiome as a mediator due to the ex
Externí odkaz:
https://doaj.org/article/71772f22b3394d649e1000c2f1ac9e11
Autor:
Jing Xue, Raad Z. Gharaibeh, Edward W. Pietryk, Cory Brouwer, Lisa M. Tarantino, William Valdar, Folami Y. Ideraabdullah
Publikováno v:
Epigenetics, Vol 13, Iss 9, Pp 959-974 (2018)
Suboptimal environmental conditions during development can substantially alter the epigenome. Stable environmentally-induced changes to the germline epigenome, in particular, have important implications for the health of the next generation. We showe
Externí odkaz:
https://doaj.org/article/da9b7d4c9137484f9e13fea72eba477b