Výsledky vyhledávání - "Ra Young Park"

Akademický článek

Splicing factor SRSF3 represses translation of p21cip1/waf1 mRNA

Autor: Jeeho Kim, Ra Young Park, Younghoon Kee, Sunjoo Jeong, Takbum Ohn

Publikováno v: Cell Death and Disease, Vol 13, Iss 11, Pp 1-11 (2022)

Abstract Serine/arginine-rich splicing factor 3 (SRSF3) is an RNA binding protein that most often regulates gene expression at the splicing level. Although the role of SRSF3 in mRNA splicing in the nucleus is well known, its splicing-independent role

Externí odkaz: https://doaj.org/article/2dd844980d524694ac8cc3f69d5a008b

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Akademický článek

NEDDylation promotes stress granule assembly

Autor: Aravinth Kumar Jayabalan, Anthony Sanchez, Ra Young Park, Sang Pil Yoon, Gum-Yong Kang, Je-Hyun Baek, Paul Anderson, Younghoon Kee, Takbum Ohn

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Stress granules that form in response to stress contain translationally stalled mRNPs and play important roles in cellular homeostasis. Here the authors implicate SRSF3 neddylation as an important factor in the formation of stress granules in respons

Externí odkaz: https://doaj.org/article/81168d0d790b4089a2d9c56c3252fc66

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A bilirubin-conjugated chitosan nanotheranostics system as a platform for reactive oxygen species stimuli-responsive hepatic fibrosis therapy

Autor: Jae Hyuk Lee, Suchithra Poilil Surendran, Reju George Thomas, Yong Yeon Jeong, Ra-Young Park, Myeong Ju Moon

Publikováno v: Acta Biomaterialia. 116:356-367

The development of nanoparticles that can be used as stimuli-responsive drug carriers for the treatment of different diseases has been an emerging area of research. In this study, we designed a chitosan-bilirubin micelle (ChiBil) carrying losartan, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c2935e0da8e575bf18d0c5180e4051
https://doi.org/10.1016/j.actbio.2020.09.014

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Effect of hepato-toxins in the acceleration of hepatic fibrosis in hepatitis B mice

Autor: Doo Hyun Kim, Myeong Ju Moon, Ra-Young Park, Reju George Thomas, Suchithra Poilil Surendran, Yong Yeon Jeong, Kyun-Hwan Kim

Publikováno v: PLoS ONE, Vol 15, Iss 5, p e0232619 (2020)
PLoS ONE

Chronic liver diseases such as hepatitis B viral (HBV) infection and liver fibrosis have been a major health problem worldwide. However, less research has been conducted owing to the lack of animal models. The key purpose of this study was to determi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1512d8c8b35008f7b62a8bd8c193fc
https://doaj.org/article/5dcb050547884e9bb333d7d8a554597d

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Avenanthramide-C Restores Impaired Plasticity and Cognition in Alzheimer's Disease Model Mice

Autor: Jihoon Jo, Manikandan Samidurai, Seon Young Yu, Ra Young Park, Hyung-Seok Kim, Hee Kyung Kang, Yu Young Lee, Hyung Joon Park, Won Seok Choi, Vijay Sankar Ramasamy, Semi Hong, Ming Wang

Publikováno v: Molecular neurobiology. 57(1)

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by cognitive decline and dementia with no effective treatment. Here, we investigated a novel compound from oats named avenanthramide-C (Avn-C), on AD-related memory i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9b7b078186f3dae7882cfc1f528859
https://pubmed.ncbi.nlm.nih.gov/31332763

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Bioactive Nanoparticles for Cancer Immunotherapy

Autor: Suchithra Poilil Surendran, Yong Yeon Jeong, Myeong Ju Moon, Ra-Young Park

Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 12, p 3877 (2018)
International Journal of Molecular Sciences

Currently, immunotherapy is considered to be one of the effective treatment modalities for cancer. All the developments and discoveries in this field up to the recent Nobel Prize add to the interest for research into this vast area of study. Targetin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e856e60d7e894852973d2eb9696f89a
https://www.mdpi.com/1422-0067/19/12/3877

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Regulation of Cellular RNA Nano-Particle Assembly by Splicing Factor SRp20

Autor: Jeeho Kim, Takbum Ohn, Ra Young Park, Hyeon Ho Kim, Sang Pil Yoon

Publikováno v: Journal of Nanoscience and Nanotechnology. 13:184-187

Cellular RNA nano-particles (RNA granules) such as stress granule (SG) and P-body (PB) are translationally silenced mRNA-protein complexes. Previously, a genome-wide loss-of-function screen using oligomeric siRNAs targeting potential drug target gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5a1e301b9fd656e8b070c38dce82ad
https://doi.org/10.1166/jnn.2013.6951

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NEDDylation promotes stress granule assembly

Autor: Aravinth Kumar Jayabalan, Sang Pil Yoon, Je-Hyun Baek, Anthony Sanchez, Younghoon Kee, Takbum Ohn, Gum-Yong Kang, Paul A. Anderson, Ra Young Park

Publikováno v: Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
NATURE COMMUNICATIONS(7)

Stress granules (SGs) harbour translationally stalled messenger ribonucleoproteins and play important roles in regulating gene expression and cell fate. Here we show that neddylation promotes SG assembly in response to arsenite-induced oxidative stre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c76a74e513650668111167a6e1c4eaca
https://pubmed.ncbi.nlm.nih.gov/27381497

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