A captured room temperature stable Wheland intermediate as a key structure for the orthogonal decoration of 4-amino-pyrido[2,3-d]pyrimidin-7(8H)-ones

Autor: Raimon Puig de la Bellacasa, José I. Borrell, Xavier Batllori, Jordi Teixidó, Oriol Vallcorba, Claudi de Rocafiguera, Raül Ondoño, Iñaki Galve, Cristina Puigjaner, Mercè Font-Bardia

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona

Wheland intermediates are usually unstable compounds and only a few have been isolated at very low temperatures. During our work on tyrosine kinase inhibitors, we studied the bromination of 7 in order to obtain a dibromo substituted pyrido[2,3-d]pyri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::331a963946d52c0e0beb98f7d08da8ee
https://doi.org/10.1039/d0ob01785j

Design of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1

Autor: Alex Perálvarez-Marín, Ángel Lirio, Roger Estrada-Tejedor, Germana Falcone, Beatrice Cardinali, Claudia Provenzano, Manuel Pérez-Alonso, Raül Ondoño, Carlos Elvira, Elena Álvarez-Marimon, José I. Borrell

Publikováno v: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 51-61 (2021)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

Graphical abstract
Highlights • Drug design with rational methods, using structure-based methods. • Novel RNA binders based on pyrido[2,3-d]pyrimidin-7-(8H)-ones. • Myotonic Dystrophy type 1 small molecule drug discovery.
Myotonic Dys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4396f75b60355e3ea1b162c87c827b30
https://pubmed.ncbi.nlm.nih.gov/33363709