Zobrazeno 1 - 10
of 299
pro vyhledávání: '"Raúl M Luque"'
Autor:
Alicia Villa-Osaba, Manuel D Gahete, José Córdoba-Chacón, Luis de Lecea, Ana I Pozo-Salas, Francisco Javier Delgado-Lista, Marina Álvarez-Benito, José López-Miranda, Raúl M Luque, Justo P Castaño
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120955 (2015)
Locally produced growth hormone (GH) and IGF-I are key factors in the regulation of mammary gland (MG) development and may be important in breast cancer development/progression. Somatostatin (SST) and cortistatin (CORT) regulate GH/IGF-I axis at vari
Externí odkaz:
https://doaj.org/article/00fa6ed0908d4084aa845e2d03c290fa
Autor:
Manel Puig-Domingo, Raúl M Luque, Jordi L Reverter, Laura M López-Sánchez, Manuel D Gahete, Michael D Culler, Gonzalo Díaz-Soto, Francisco Lomeña, Mattia Squarcia, José Luis Mate, Mireia Mora, Laureano Fernández-Cruz, Oscar Vidal, Antonio Alastrué, Jose Balibrea, Irene Halperin, Dídac Mauricio, Justo P Castaño
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85527 (2014)
Somatostatin receptors (ssts) are expressed in thyroid cancer cells, but their biological significance is not well understood. The aim of this study was to assess ssts in well differentiated (WDTC) and poorly differentiated thyroid cancer (PDTC) by m
Externí odkaz:
https://doaj.org/article/c720d5555a354221b8e584d4004b00a5
Autor:
Belén Chanclón, Raúl M Luque, José Córdoba-Chacón, Manuel D Gahete, Ana I Pozo-Salas, Justo P Castaño, Francisco Gracia-Navarro, Antonio J Martínez-Fuentes
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57834 (2013)
Ghrelin-system components [native ghrelin, In1-ghrelin, Ghrelin-O-acyltransferase enzyme (GOAT) and receptors (GHS-Rs)] are expressed in a wide variety of tissues, including the pancreas, where they exert different biological actions including regula
Externí odkaz:
https://doaj.org/article/4e9ef42c29e64d3981d5f3d4e37dbd45
Autor:
Ricardo Blázquez-Encinas, Víctor García-Vioque, Teresa Caro-Cuenca, María Trinidad Moreno-Montilla, Federica Mangili, Emilia Alors-Pérez, Sebastian Ventura, Aura D. Herrera-Martínez, Paula Moreno-Casado, Marco A. Calzado, Ángel Salvatierra, María A. Gálvez-Moreno, Lynnette Fernandez-Cuesta, Matthieu Foll, Raúl M. Luque, Nicolas Alcala, Sergio Pedraza-Arevalo, Alejandro Ibáñez-Costa, Justo P. Castaño
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of tumors ranging from indolent lesions with good prognosis to highly aggressive cancers. Carcinoids are the rarest LungNENs, display low to intermediate mali
Externí odkaz:
https://doaj.org/article/d52791785b0348c3acabc1dd11422717
Autor:
Emilia Alors-Pérez, Sergio Pedraza-Arevalo, Ricardo Blázquez-Encinas, María Trinidad Moreno-Montilla, Víctor García-Vioque, Inmaculada Berbel, Raúl M. Luque, Bruno Sainz, Alejandro Ibáñez-Costa, Justo P. Castaño
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-16 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) remains one of the most lethal cancers worldwide, mainly due to its late diagnosis and lack of effective therapies, translating into a low 5-year 12% survival rate, despite extensive clinical efforts t
Externí odkaz:
https://doaj.org/article/a84214f7f90144bfaa84a7594e4529bf
Autor:
Julia Castillo-González, José Luis Ruiz, Ignacio Serrano-Martínez, Irene Forte-Lago, Ana Ubago-Rodriguez, Marta Caro, Jesús Miguel Pérez-Gómez, Alejandro Benítez-Troncoso, Eduardo Andrés-León, Macarena Sánchez-Navarro, Raúl M. Luque, Elena González-Rey
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-25 (2023)
Abstract Background Brain activity governing cognition and behaviour depends on the fine-tuned microenvironment provided by a tightly controlled blood–brain barrier (BBB). Brain endothelium dysfunction is a hallmark of BBB breakdown in most neurode
Externí odkaz:
https://doaj.org/article/b2caf9906f144b4b854abd568b8551c1
Autor:
Maria Loreta Libero, Antonio J. Montero-Hidalgo, Lucia Recinella, Raúl M. Luque, Daniele Generali, Alessandra Acquaviva, Giustino Orlando, Claudio Ferrante, Luigi Menghini, Simonetta Cristina Di Simone, Nilofar Nilofar, Annalisa Chiavaroli, Luigi Brunetti, Sheila Leone
Publikováno v:
Nutrients, Vol 16, Iss 17, p 3025 (2024)
Chronic inflammation is a recognized risk factor for various cancers, including prostate cancer (PCa). We aim to explore the potential protective effects of aged black garlic extract (ABGE) against inflammation-induced prostate damage and its impact
Externí odkaz:
https://doaj.org/article/9ad61ed6ead649ab846a9524b1d85312
Autor:
Cristóbal Blanco-Acevedo, Eduardo Aguera-Morales, Antonio C. Fuentes-Fayos, Nazareth Pelaez-Viña, Rosa Diaz-Pernalete, Nazaret Infante-Santos, Ana Muñoz-Jurado, Manuel F. Porras-Pantojo, Alejandro Ibáñez-Costa, Raúl M. Luque, Juan Solivera-Vela
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1666 (2024)
Background: Intracerebral hemorrhages (ICHs) are prevalent, with high morbidity and mortality. We analyzed whether decompressive craniectomy (DC) without evacuation of the acute intraparenchymal hematoma could produce better functional outcomes than
Externí odkaz:
https://doaj.org/article/43592877afa44089ae3982c831807880
The somatostatin analogue octreotide inhibits growth of small intestine neuroendocrine tumour cells.
Autor:
Su-Chen Li, Cécile Martijn, Tao Cui, Ahmed Essaghir, Raúl M Luque, Jean-Baptiste Demoulin, Justo P Castaño, Kjell Öberg, Valeria Giandomenico
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48411 (2012)
Octreotide is a widely used synthetic somatostatin analogue that significantly improves the management of neuroendocrine tumours (NETs). Octreotide acts through somatostatin receptors (SSTRs). However, the molecular mechanisms leading to successful d
Externí odkaz:
https://doaj.org/article/9793950de5904fd884b299674b0de96d
Autor:
Manuel D Gahete, José Córdoba-Chacón, Marta Hergueta-Redondo, Antonio J Martínez-Fuentes, Rhonda D Kineman, Gema Moreno-Bueno, Raúl M Luque, Justo P Castaño
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23302 (2011)
The human ghrelin gene, which encodes the ghrelin and obestatin peptides, contains 5 exons (Ex), with Ex1-Ex4 encoding a 117 amino-acid (aa) preproprotein that is known to be processed to yield a 28-aa (ghrelin) and/or a 23-aa (obestatin) mature pept
Externí odkaz:
https://doaj.org/article/35a08407df294c4c981229d05bba0811