Zobrazeno 1 - 10
of 324
pro vyhledávání: '"Raúl J.-Andrade"'
Publikováno v:
Exploration of Digestive Diseases, Vol 2, Iss 5, Pp 202-222 (2023)
Drug-induced liver injury (DILI) is an adverse reaction to drugs and other xenobiotics that can have serious consequences and jeopardise progress in pharmacological therapy. While DILI is predominantly hepatocellular, a non-negligible percentage of p
Externí odkaz:
https://doaj.org/article/8913248e32124acc9bfefeead2afcb91
Autor:
Jane I. Grove, Camilla Stephens, M. Isabel Lucena, Raúl J. Andrade, Sabine Weber, Alexander Gerbes, Einar S. Bjornsson, Guido Stirnimann, Ann K. Daly, Matthias Hackl, Kseniya Khamina-Kotisch, Jose J. G. Marin, Maria J. Monte, Sara A. Paciga, Melanie Lingaya, Shiva S. Forootan, Christopher E. P. Goldring, Oliver Poetz, Rudolf Lombaard, Alexandra Stege, Helgi K. Bjorrnsson, Mercedes Robles-Diaz, Dingzhou Li, Thi Dong Binh Tran, Shashi K. Ramaiah, Sophia L. Samodelov, Gerd A. Kullak-Ublick, Guruprasad P. Aithal, on behalf of the TransBioLine consortium
Publikováno v:
Diagnostic and Prognostic Research, Vol 7, Iss 1, Pp 1-15 (2023)
Abstract A lack of biomarkers that detect drug-induced liver injury (DILI) accurately continues to hinder early- and late-stage drug development and remains a challenge in clinical practice. The Innovative Medicines Initiative’s TransBioLine consor
Externí odkaz:
https://doaj.org/article/01c9031ea63844faa64609c76d355eda
Autor:
Hao Niu, Pablo Solis-Muñoz, Miren García-Cortés, Judith Sanabria-Cabrera, Mercedes Robles-Diaz, Rocío Romero-Flores, Elvira Bonilla-Toyos, Aida Ortega-Alonso, José M. Pinazo-Bandera, María R. Cabello, Fernando Bessone, Nelia Hernandez, M. Isabel Lucena, Raúl J. Andrade, Inmaculada Medina-Caliz, Ismael Alvarez-Alvarez
Publikováno v:
Pharmacological Research, Vol 199, Iss , Pp 107030- (2024)
The impact of prior drug allergies (PDA) on the clinical features and outcomes of patients who develop idiosyncratic drug-induced liver injury (DILI) is largely unknown. We aimed to assess the clinical presentation and outcomes of DILI patients based
Externí odkaz:
https://doaj.org/article/6e8e486e10204ce4a44a435c16afc6c1
Liver injury in non-alcoholic fatty liver disease is associated with urea cycle enzyme dysregulation
Autor:
Rocío Gallego-Durán, Javier Ampuero, Helena Pastor-Ramírez, Leticia Álvarez-Amor, Jose Antonio del Campo, Douglas Maya-Miles, Rocío Montero-Vallejo, Antonio Cárdenas-García, Mª Jesús Pareja, Sheila Gato-Zambrano, Raquel Millán, María del Carmen Rico, Amparo Luque-Sierra, Antonio Gil-Gómez, Ángela Rojas, Rocío Muñoz-Hernández, María García-Lozano, Rocío Aller, Raúl J. Andrade, Carmelo García-Monzón, Fausto Andreola, Francisco Martín, Rajiv Jalan, Manuel Romero-Gómez
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract The main aim was to evaluate changes in urea cycle enzymes in NAFLD patients and in two preclinical animal models mimicking this entity. Seventeen liver specimens from NAFLD patients were included for immunohistochemistry and gene expression
Externí odkaz:
https://doaj.org/article/6b0034b1492945a5bad81e9db024ea51
Autor:
Hui Ye, Chaobo Chen, Hanghang Wu, Kang Zheng, Beatriz Martín-Adrados, Esther Caparros, Rubén Francés, Leonard J. Nelson, Manuel Gómez del Moral, Iris Asensio, Javier Vaquero, Rafael Bañares, Matías A. Ávila, Raúl J. Andrade, M. Isabel Lucena, Maria Luz Martínez-Chantar, Helen L. Reeves, Steven Masson, Richard S. Blumberg, Jordi Gracia-Sancho, Yulia A. Nevzorova, Eduardo Martínez-Naves, Francisco Javier Cubero
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-13 (2022)
Abstract Acetaminophen (APAP) hepatotoxicity induces endoplasmic reticulum (ER) stress which triggers the unfolded protein response (UPR) in hepatocytes. However, the mechanisms underlying ER stress remain poorly understood, thus reducing the options
Externí odkaz:
https://doaj.org/article/1cfd4329e56e47219aae65911f141a1f
Autor:
Camila A. Picchio, Sabela Lens, Manuel Hernandez-Guerra, Juan Arenas, Raúl J. Andrade, Javier Crespo, Javier García-Samaniego, Manuel Romero-Gómez, Juan Turnes, José Luis Calleja, Miguel Ángel Simón, Trenton M. White, Mar Riveiro-Barciela, Anna Pocurull, Dalia Morales-Arraez, Alexandra Gómez, Maria Buti, Jeffrey V. Lazarus
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate treatment after significant disease progression face increased risk of severe liver complications and death. Data are scarce on the chara
Externí odkaz:
https://doaj.org/article/d262e6bd25e842b3a55ada02b9f2ae1b
Autor:
Antonio Segovia-Zafra, Daniel E. Di Zeo-Sánchez, Carlos López-Gómez, Zeus Pérez-Valdés, Eduardo García-Fuentes, Raúl J. Andrade, M. Isabel Lucena, Marina Villanueva-Paz
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3685-3726 (2021)
Idiosyncratic drug-induced liver injury (iDILI) encompasses the unexpected harms that prescription and non-prescription drugs, herbal and dietary supplements can cause to the liver. iDILI remains a major public health problem and a major cause of dru
Externí odkaz:
https://doaj.org/article/38e44794bdef46a2812986a12e8312b6
Autor:
Alejandro-José García-Ferreira, Aida Ortega-Alonso, Julia Cobos-Rodríguez, Paula Bardón-de-Tena, Miguel Calderón-Cid, Alberto García-García, M.ª-Dolores García-Escaño, Ramiro Alcántara-Benítez, Encarnación Clavijo-Frutos, Miren García-Cortés, Raúl J.-Andrade
Publikováno v:
Revista Espanola de Enfermedades Digestivas, Vol 110, Iss 6, Pp 380-385
RESUMEN En el año 2016 se detectó en la provincia de Málaga un brote de hepatitis A en pacientes con características epidemiológicas especiales, con un predominio de sujetos del sexo masculino. Presentamos 51 casos de hepatitis A aguda con una m
Externí odkaz:
https://doaj.org/article/3de1dce046f84eb7940c6c96f7c97fb8
Autor:
Estefanía Caballano-Infantes, Ailec Ho-Plágaro, Carlos López-Gómez, Flores Martín-Reyes, Francisca Rodríguez-Pacheco, Bernard Taminiau, Georges Daube, Lourdes Garrido-Sánchez, Guillermo Alcaín-Martínez, Raúl J. Andrade, Miren García-Cortés, M. Isabel Lucena, Eduardo García-Fuentes, Cristina Rodríguez-Díaz
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 818 (2023)
Clostridioides difficile infection (CDI) appears to be associated with different liver diseases. C. difficile secretes membrane vesicles (MVs), which may be involved in the development of nonalcoholic fatty liver disease (NALFD) and drug-induced live
Externí odkaz:
https://doaj.org/article/b090a3c7b9da40bd8d79d5508e5efe57
Autor:
Alejandro Cueto-Sanchez, Judith Sanabria Cabrera, Mercedes Robles-Diaz, Aida Ortega-Alonso, Miren Garcia Cortes, Enrique del Campo-Herrera, Rocio Gonzalez-Grande, Miguel Jimenez-Perez, Francisco Ruiz-Cabello, M Isabel Lucena, Camilla Stephens, Raúl J Andrade
Publikováno v:
Annals of Hepatology, Vol 24, Iss , Pp 100489- (2021)
Introduction: Idiosyncratic DILI is a challenging condition, believed to involve the immune system. This hypothesis is supported by various identified HLA risk alleles. Objectives: To evaluate a potential role of the immune system in DILI through leu
Externí odkaz:
https://doaj.org/article/939b0fcda1804da28889a44a9b58db2d