Výsledky vyhledávání - "Raúl, Navaridas"

Akademický článek

Multiple endocrine defects in adult-onset Sprouty1/2/4 triple knockout mice

Autor: Gisela Altés, Anna Olomí, Aida Perramon-Güell, Sara Hernández, Anna Casanovas, Aurora Pérez, Juan Miguel Díaz-Tocados, José Manuel Valdivielso, Cristina Megino, Raúl Navaridas, Xavier Matias-Guiu, Ophir D. Klein, Joaquim Egea, Xavi Dolcet, Andrée Yeramian, Mario Encinas

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract Genes of the Sprouty family (Spry1-4) are feedback inhibitors of receptor tyrosine kinases, especially of Ret and the FGF receptors. As such, they play distinct and overlapping roles in embryo morphogenesis and are considered to be tumor sup

Externí odkaz: https://doaj.org/article/c35f82b053404988a6db6232e37d7598

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Akademický článek

In Vivo Intra‐Uterine Delivery of TAT‐Fused Cre Recombinase and CRISPR/Cas9 Editing System in Mice Unveil Histopathology of Pten/p53‐Deficient Endometrial Cancers

Autor: Raúl Navaridas, Maria Vidal‐Sabanés, Anna Ruiz‐Mitjana, Gisela Altés, Aida Perramon‐Güell, Andree Yeramian, Joaquim Egea, Mario Encinas, Sonia Gatius, Xavier Matias‐Guiu, Xavier Dolcet

Publikováno v: Advanced Science, Vol 10, Iss 32, Pp n/a-n/a (2023)

Abstract Phosphatase and TENsin homolog (Pten) and p53 are two of the most frequently mutated tumor suppressor genes in endometrial cancer. However, the functional consequences and histopathological manifestation of concomitant p53 and Pten loss of f

Externí odkaz: https://doaj.org/article/a10e9bdc8afb41bba8c8fa70ed603e4f

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Akademický článek

Oxidative stress‐induced FAK activation contributes to uterine serous carcinoma aggressiveness

Publikováno v: Molecular Oncology, Vol 17, Iss 1, Pp 98-118 (2023)

Uterine serous carcinoma (USC) is an aggressive form of endometrial cancer (EC), characterized by its high propensity for metastases. In fact, while endometrioid endometrial carcinoma (EEC), which accounts for 85% of EC, presents a good prognosis, US

Externí odkaz: https://doaj.org/article/f663469d36c74406919fb1ffb516ab40

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Akademický článek

Lack of extracellular matrix switches TGF-β induced apoptosis of endometrial cells to epithelial to mesenchymal transition

Autor: Anna Ruiz-Mitjana, Raúl Navaridas, Maria Vidal-Sabanés, Aida Perramon-Güell, Andree Yeramian, Isidre Felip, Núria Eritja, Joaquim Egea, Mario Encinas, Xavier Matias-Guiu, Xavier Dolcet

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)

Abstract The extracellular matrix and the correct establishment of epithelial cell polarity plays a critical role in epithelial cell homeostasis and cell polarity. In addition, loss of tissue structure is a hallmark of carcinogenesis. In this study,

Externí odkaz: https://doaj.org/article/f38b438a650b4c409f3101a0c6d92387

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Akademický článek

ARID1A‐deficient cells require HDAC6 for progression of endometrial carcinoma

Autor: Cristina Megino‐Luque, Pol Sisó, Natalia Mota‐Martorell, Raúl Navaridas, Inés de laRosa, Izaskun Urdanibia, Manel Albertí‐Valls, Maria Santacana, Miquel Pinyol, Núria Bonifaci, Anna Macià, David Llobet‐Navas, Sònia Gatius, Xavier Matias‐Guiu, Núria Eritja

Publikováno v: Molecular Oncology, Vol 16, Iss 11, Pp 2235-2259 (2022)

AT‐rich interactive domain‐containing protein 1A (ARID1A) loss‐of‐function mutation accompanied by a loss of ARID1A protein expression is frequently observed in endometrial carcinomas. However, the molecular mechanisms linking these genetic c

Externí odkaz: https://doaj.org/article/88829f0c96d5428fb487eeec1a5e9881

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Akademický článek

Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species

Autor: Natividad Blasco, Aida Beà, Gisel Barés, Cristina Girón, Raúl Navaridas, Andrea Irazoki, Guillermo López-Lluch, Antonio Zorzano, Xavier Dolcet, Marta Llovera, Daniel Sanchis

Publikováno v: Redox Biology, Vol 37, Iss , Pp 101736- (2020)

The apoptotic nuclease EndoG is involved in mitochondrial DNA replication. Previous results suggested that, in addition to regulate cardiomyocyte hypertrophy, EndoG could be involved in cell proliferation. Here, by using in vivo and cell culture mode

Externí odkaz: https://doaj.org/article/3e37a358d10e4c7286657f704b4b30d3

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Antitumor Effects of Ral-GTPases Downregulation in Glioblastoma

Autor: Tània Cemeli, Marta Guasch-Vallés, Marina Ribes-Santolaria, Eva Ibars, Raúl Navaridas, Xavier Dolcet, Neus Pedraza, Neus Colomina, Jordi Torres-Rosell, Francisco Ferrezuelo, Judit Herreros, Eloi Garí

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8199
Repositorio Abierto de la UdL
Universitad de Lleida

Glioblastoma (GBM) is the most common tumor in the central nervous system in adults. This neoplasia shows a high capacity of growth and spreading to the surrounding brain tissue, hindering its complete surgical resection. Therefore, the finding of ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d4abbde3c3e576f0582647443eaa68
https://pubmed.ncbi.nlm.nih.gov/35897776

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T-Type Calcium Channels as Potential Therapeutic Targets in Vemurafenib-Resistant BRAFV600E Melanoma

Autor: Oscar Maiques, Xavier Dolcet, Izaskun Urdanibia, R.M. Penín, Sandra García-Mulero, Pol Sisó, Nuria Eritja, Carla Barceló, X. Soria, Rosa M. Martí, Isidre Felip, Anna Macià, Josep M. Piulats, Cristina Megino, Raúl Navaridas, Rebeca Sanz-Pamplona, Xavier Matias-Guiu

Publikováno v: Journal of Investigative Dermatology. 140:1253-1265

Melanoma is a malignant neoplasia that is highly resistant to chemotherapy and radiotherapy and is associated with poor prognosis in advanced stage. Targeting melanoma that harbors the common BRAFV600E mutation with kinase inhibitors, such as vemuraf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b1b83fedd73015ee4538e738f57635a
https://doi.org/10.1016/j.jid.2019.11.014

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