The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 – therapy

Autor: Dg, Hackam, Na, Khan, Br, Hemmelgarn, Sw, Rabkin, Rm, Touyz, Nr, Campbell, Padwal R, Ts, Campbell, Mp, Lindsay, Michael Hill, Rr, Quinn, Jl, Mahon, Rj, Herman, El, Schiffrin, Ruzicka M, Larochelle P, Rd, Feldman, Lebel M, Poirier L, Jm, Arnold, Gw, Moe, Jg, Howlett, Trudeau L, Sl, Bacon, Rj, Petrella, Milot A, Ja, Stone, Drouin D, Jm, Boulanger, Sharma M, Hamet P, Fodor G, Gk, Dresser, Sg, Carruthers, Pylypchuk G, Ed, Burgess, Kd, Burns, Vallée M, Gv, Prasad, Re, Gilbert, La, Leiter, Jones C, Ri, Ogilvie, Woo V, Pa, Mcfarlane, Ra, Hegele, Sw, Tobe, Canadian Hypertension Education Program

Publikováno v: Europe PubMed Central
Scopus-Elsevier

Objective To update the evidence-based recommendations for the prevention and treatment of hypertension in adults for 2010. Options and outcomes For lifestyle and pharmacological interventions, randomized trials and systematic reviews of trials were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b2473387a8c74203fd0c112a0447020
https://doi.org/10.1016/s0828-282x(10)70379-2

LMNA mutation position predicts organ system involvement in laminopathies

Autor: Ra, Hegele

Publikováno v: Clinical genetics. 68(1)

The underlying disease mechanisms likely include mutation effects on the nuclear envelope and on interactions between lamins and transcription factors. At the same time, can a simple genomic attribute -- for instance, mutation position within the LMN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62150c2da753781f152ef365dfe07348
https://pubmed.ncbi.nlm.nih.gov/17539910

Sanfilippo syndrome type D : natural history and identification of 3 novel mutations in the GNS Gene

Autor: Anna Jansen, Hai Thanh Cao, Frédéric Kaplan, Silver, K., Leonard, G., Linda De Meirleir, Willy Lissens, Ingeborg Liebaers, Veilleux, M., Andermann, M., Ra Hegele, Andermann, E.

Publikováno v: Anna Jansen
Vrije Universiteit Brussel

BACKGROUND: Mucopolysaccharidosis type IIID (MPS-IIID), or Sanfilippo syndrome type D, is a rare autosomal recessive lysosomal storage disorder caused by mutations in the N-acetylglucosamine-6-sulfatase (GNS) gene, leading to impaired degradation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a682c18c5188965b269a013f5ca6cbae
https://researchportal.vub.be/en/publications/617c4b09-eb36-4dd4-af53-ae34687d42ce

Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases.

Autor: Lin WZ; Department of Pharmacology & Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Ontario, Canada., Yu D; Department of Pharmacology & Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Ontario, Canada., Xiong LY; Department of Pharmacology & Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Ontario, Canada., Zebarth J; Department of Pharmacology & Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Ontario, Canada., Wang R; Department of Pharmacology & Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Neuropsychopharmacology Research Group, Sunnybrook Research Institute, Toronto, Ontario, Canada., Fischer CE; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, Ontario, Canada., Rajji TK; Toronto Dementia Research Alliance, University of Toronto, Toronto, Ontario, Canada., Tang-Wai DF; Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada.; Division of Neurology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Tartaglia C; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada., Saposnik G; Stroke Outcomes and Decision Neuroscience Research Unit, Division of Neurology, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada., Swartz RH; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Division of Neurology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Grimes DA; Division of Neurology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.; Brain and Mind Research Institute, University of Ottawa, Ottawa, Ontario, Canada., Lang AE; Division of Neurology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada., Hegele RA; Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada.; Robarts Research Institute, Western University, London, Ontario, Canada., Farhan S; Robarts Research Institute, Western University, London, Ontario, Canada.; Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, Montreal, Quebec, Canada., Ramirez J; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada., Symons S; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada., Goubran M; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Binns MA; Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, Canada., Lou W; Department of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada., Dixon RA; Department of Psychology, Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada., Orange JB; School of Communication Sciences and Disorders, Western University, London, Ontario, Canada.; Canadian Centre for Activity and Aging, Western University, London, Ontario, Canada., Roberts AC; School of Communication Sciences and Disorders, Western University, London, Ontario, Canada.; Canadian Centre for Activity and Aging, Western University, London, Ontario, Canada., Troyer AK; Department of Psychology, University of Toronto, Toronto, Ontario, Canada.; Neuropsychology and Cognitive Health, Baycrest Health Sciences, Toronto, Ontario, Canada., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Herrmann N; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Neuropsychopharmacology Research Group, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Department of Psychiatry, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Rabin JS; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Division of Neurology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., MacIntosh BJ; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Department of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Masellis M; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Division of Neurology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada., Lanctôt KL; Department of Pharmacology & Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Black SE; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; Toronto Dementia Research Alliance, University of Toronto, Toronto, Ontario, Canada.; Division of Neurology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.; Sandra Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, Ontario, Canada., Swardfager W; Department of Pharmacology & Toxicology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.; Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.; KITE Research Institute, Toronto Rehabilitation Institute-University Health Network, Toronto, Ontario, Canada.; Sandra Black Centre for Brain Resilience and Recovery, Sunnybrook Research Institute, Toronto, Ontario, Canada.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Nov 19. Date of Electronic Publication: 2024 Nov 19.

Vascular calcification in chronic kidney disease associated with pathogenic variants in ABCC6.

Autor: Schott C; Department of Biochemistry, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada. Electronic address: cschott2@uwo.ca., Dilliott AA; Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital, McGill University, 845 Sherbrooke Street, West Montreal, QC H3A 0G4, Canada., Wang J; Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 3K7, Canada., McIntyre AD; Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 3K7, Canada., Son S; Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada., Colaiacovo S; Division of Medical Genetics, Department of Pediatrics, Victoria Hospital, London Health Science Center, 800 Commissioners Rd E, London, ON N6A 5W9, Canada., Baker C; London Health Sciences Centre, 339 Windermere Rd, London N6A 3K7, ON, Canada., Gunaratnam L; Department of Medicine, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada., House AA; London Health Sciences Centre, 339 Windermere Rd, London N6A 3K7, ON, Canada; Department of Medicine, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada., Susan Huang SH; Department of Medicine, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada., Iyer H; Department of Medicine, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada., Johnson J; Department of Medicine, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada., Lotfy K; Department of Medicine, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada., Masellis M; LC Campbell Cognitive Neurology Research Unit, Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada., Munoz DP; Centre for Neuroscience Studies, Queen's University, 18 Stuart St, Kingston, ON K7L 3N6, Canada., Rehman F; Department of Medicine, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada., Roshanov PS; Department of Medicine, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada., Swartz RH; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre and Department of Medicine (Neurology), University of Toronto, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada., Weir MA; Department of Medicine, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada., Hegele RA; Robarts Research Institute, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 3K7, Canada; Department of Medicine, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada., Connaughton DM; Department of Biochemistry, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada; Division of Medical Genetics, Department of Pediatrics, Victoria Hospital, London Health Science Center, 800 Commissioners Rd E, London, ON N6A 5W9, Canada; London Health Sciences Centre, 339 Windermere Rd, London N6A 3K7, ON, Canada; Department of Medicine, Schulich School of Medicine & Dentistry, Western University, 1151 Richmond St, London, ON N6A 5C1, Canada.

Publikováno v: Gene [Gene] 2024 Nov 15; Vol. 927, pp. 148731. Date of Electronic Publication: 2024 Jun 27.