Zobrazeno 1 - 10
of 119
pro vyhledávání: '"RZZ"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
During mitosis, the interaction of kinetochores (KTs) with microtubules (MTs) drives chromosome congression to the spindle equator and supports the segregation of sister chromatids. Faithful genome partition critically relies on the ability of chromo
Externí odkaz:
https://doaj.org/article/de67f044e85f43419e96c65fce0c7fce
Autor:
Eleni Petsalaki, George Zachos
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
The mitotic spindle checkpoint delays anaphase onset until all chromosomes have achieved stable kinetochore-microtubule attachments. Here, we discuss recent findings showing that CHMP4C, a component of the endosomal sorting complex required for trans
Externí odkaz:
https://doaj.org/article/c7dce933f0894f1c8857550ee5fd5936
Akademický článek
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Publikováno v:
Journal of Cancer
Pancreatic cancer (PC) is an intractable cancer that is difficult to diagnose early and has a 5-year survival rate of less than 8%. ZW10-interacting kinetochore protein (ZWINT) is a crucial gene that contributes to chromosome instability and is essen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e8f640931e47e66e7ebf08c12c185c7
http://europepmc.org/articles/PMC7477444
http://europepmc.org/articles/PMC7477444
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
During mitosis, the interaction of kinetochores (KTs) with microtubules (MTs) drives chromosome congression to the spindle equator and supports the segregation of sister chromatids. Faithful genome partition critically relies on the ability of chromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dc122c4844b14c5fcfe727459efe13
https://pubmed.ncbi.nlm.nih.gov/35155423
https://pubmed.ncbi.nlm.nih.gov/35155423
Publikováno v:
Open Biology, Vol 5, Iss 11 (2015)
The spindle assembly checkpoint is a surveillance mechanism that blocks anaphase onset until all chromosomes are properly attached to microtubules of the mitotic spindle. Checkpoint activity requires kinetochore localization of Mad1/Mad2 to inhibit a
Externí odkaz:
https://doaj.org/article/19f3d81e12dc41cc81a5d45f852b9a47
Autor:
Chan Tian, Fengjie Yuan, Lina Wang, Nan Zhang, Dan Li, Xin Yang, Yuanshuai Song, Ying Zhao, Ximin Jin, Wei-Guo Zhu
Publikováno v:
Nucleic Acids Research
The spindle assembly checkpoint (SAC) ensures the fidelity of chromosome segregation during mitosis. Here, we show that ULK1, a serine/threonine kinase that plays a key role in initiation of autophagy, also has an important function in the activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6355fd102dff16faa8762213c95d304f
https://doi.org/10.1093/nar/gkz602
https://doi.org/10.1093/nar/gkz602
Akademický článek
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Publikováno v:
Cell Cycle
To maintain genome stability, chromosomes must be equally distributed among daughter cells at the end of mitosis. The accuracy of chromosome segregation requires sister-kinetochores to stably attach to microtubules emanating from opposite spindle pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b452ce67a0b01a0b8f5b8e15cca34867
https://europepmc.org/articles/PMC7469663/
https://europepmc.org/articles/PMC7469663/
Autor:
Giuseppe Ciossani, Magda Camacho Reis, Lindsey A. Allan, Geert J. P. L. Kops, Sabine Wohlgemuth, Adrian T. Saurin, Pim J. Huigs in ‘t Veld, Andrea Musacchio
Publikováno v:
The EMBO Journal
EMBO Journal, 39(12). Nature Publishing Group
EMBO Journal, 39(12). Nature Publishing Group
Cyclin B:CDK1 is the master kinase regulator of mitosis. We show here that, in addition to its kinase functions, mammalian Cyclin B also scaffolds a localised signalling pathway to help preserve genome stability. Cyclin B1 localises to an expanded re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::433103395e791b8dee108e712a049443
https://doi.org/10.15252/embj.2019103180
https://doi.org/10.15252/embj.2019103180