Zobrazeno 1 - 10
of 788
pro vyhledávání: '"RYUZO UEDA"'
Autor:
Shoya Ono, Susumu Suzuki, Yutaro Kondo, Ikuko Okubo, Mitsuo Goto, Tetsuya Ogawa, Hidefumi Kato, Hideaki Ito, Taishi Takahara, Akira Satou, Toyonori Tsuzuki, Kazuhiro Yoshikawa, Toru Nagao, Ryuzo Ueda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Regulatory T-cells (Tregs) play a major role in suppressing anti-tumor immune responses. Mogamulizumab, an anti-CC chemokine receptor type 4 (CCR4) monoclonal antibody, depletes effector Tregs (eTregs). However, the clinical efficacy of moga
Externí odkaz:
https://doaj.org/article/47020566b5224fc5b119f9be4216c769
Tumor‐infiltrating FoxP3+ T cells are associated with poor prognosis in oral squamous cell carcinoma
Autor:
Tomio Hayashi, Kazuhiro Yoshikawa, Susumu Suzuki, Masahiko Gosho, Ryuzo Ueda, Yoshiaki Kazaoka
Publikováno v:
Clinical and Experimental Dental Research, Vol 8, Iss 1, Pp 152-159 (2022)
Abstract Objectives Squamous cell carcinoma is the most common malignancy in the oral cavity. Moreover, human papillomavirus (HPV) infection has been recently implicated in the onset of oral squamous cell carcinoma (OSCC). Regulatory T cells (Tregs)
Externí odkaz:
https://doaj.org/article/cc7e8b6bd18842ffa577560e42444a7a
Autor:
Kaoru Fujikawa, Takuro Saito, Koji Kurose, Takashi Kojima, Takeru Funakoshi, Eiichi Sato, Kazuhiro Kakimi, Shinsuke Iida, Yuichiro Doki, Mikio Oka, Ryuzo Ueda, Hisashi Wada
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0291772 (2023)
IntroductionRegulatory T cells (Tregs) have attracted attention as a novel therapeutic target to augment the clinical efficacy of immunotherapy. We conducted phase Ia and Ib trials to examine the safety and efficacy of the anti-CCR4 antibody, KW-0761
Externí odkaz:
https://doaj.org/article/5fba548ebdfa4b639e37c6021a5878a2
Autor:
Yuka Maeda, Hisashi Wada, Daisuke Sugiyama, Takuro Saito, Takuma Irie, Kota Itahashi, Kodai Minoura, Susumu Suzuki, Takashi Kojima, Kazuhiro Kakimi, Jun Nakajima, Takeru Funakoshi, Shinsuke Iida, Mikio Oka, Teppei Shimamura, Toshihiko Doi, Yuichiro Doki, Eiichi Nakayama, Ryuzo Ueda, Hiroyoshi Nishikawa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Elimination of regulatory T cells via the anti-CCR4 monoclonal antibody, mogamulizumab, is expected to augment anti-tumour immune response. Authors show here that although regulatory T cell targeting is successful, clinical improvement remains minima
Externí odkaz:
https://doaj.org/article/a5114e3a54eb4c2488d410e0289e8399
Autor:
Hiroaki Hiramatsu, Kisato Nosaka, Shigeru Kusumoto, Nobuaki Nakano, Ilseung Choi, Makoto Yoshimitsu, Yoshitaka Imaizumi, Michihiro Hidaka, Hidenori Sasaki, Junya Makiyama, Eiichi Ohtsuka, Tatsuro Jo, Masao Ogata, Asahi Ito, Kentaro Yonekura, Hiro Tatetsu, Takeharu Kato, Toshiro Kawakita, Youko Suehiro, Kenji Ishitsuka, Shinsuke Iida, Takaji Matsutani, Hiroyoshi Nishikawa, Atae Utsunomiya, Ryuzo Ueda, Takashi Ishida
Publikováno v:
Haematologica, Vol 108, Iss 4 (2022)
Externí odkaz:
https://doaj.org/article/7a719b715c4f446799368076060e4e23
Autor:
Ichiro Hanamura, Susumu Suzuki, Akinobu Ota, Satsuki Murakami, Akira Satou, Taishi Takahara, Sivasundaram Karnan, Vu Quang Lam, Ayano Nakamura, Souichi Takasugi, Kazuhiro Yoshikawa, Shogo Banno, Masayuki Ejiri, Toyonori Tsuzuki, Yoshitaka Hosokawa, Ryuzo Ueda, Akiyoshi Takami
Publikováno v:
Hemato, Vol 2, Iss 2, Pp 368-382 (2021)
The clinical and biological significance of programmed death-1 (PD-1) expression by B-lymphoma cells is largely unknown. Here, using multicolor immunofluorescent staining (MC-IF), we investigated PD-1 and PD-L1 expression in PAX5+ (B-lymphoma), CD68+
Externí odkaz:
https://doaj.org/article/aa32f8c19b92443e840c847084530e68
Autor:
Sivasundaram Karnan, Ichiro Hanamura, Akinobu Ota, Souichi Takasugi, Ayano Nakamura, Miyuki Takahashi, Kaori Uchino, Satsuki Murakami, Md Wahiduzzaman, Lam Quang Vu, Md Lutfur Rahman, Muhammad Nazmul Hasan, Toshinori Hyodo, Hiroyuki Konishi, Shinobu Tsuzuki, Kazuhiro Yoshikawa, Susumu Suzuki, Ryuzo Ueda, Masayuki Ejiri, Yoshitaka Hosokawa, Akiyoshi Takami
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-14 (2021)
Abstract Internal tandem duplication (ITD) of FMS-like tyrosine kinase 3 (FLT3) confers poor prognosis and is found in approximately 25% of cases of acute myeloid leukemia (AML). Although FLT3 inhibitors have shown clinical benefit in patients with A
Externí odkaz:
https://doaj.org/article/eae8b2e7377a4befa2da2790f20890c7
Autor:
Norio Tanaka, Seiichi Mori, Kazuma Kiyotani, Yuki Ota, Osamu Gotoh, Shigeru Kusumoto, Nobuaki Nakano, Youko Suehiro, Asahi Ito, Ilseung Choi, Eiichi Ohtsuka, Michihiro Hidaka, Kisato Nosaka, Makoto Yoshimitsu, Yoshitaka Imaizumi, Shinsuke Iida, Atae Utsunomiya, Tetsuo Noda, Hiroyoshi Nishikawa, Ryuzo Ueda, Takashi Ishida
Publikováno v:
Haematologica, Vol 107, Iss 10 (2022)
In order to identify genomic biomarkers for the outcome of mogamulizumab-containing treatment, an integrated molecular analysis of adult T-cell leukemia/lymphoma (ATL) was conducted on 64 mogamulizumab-naïve patients. Among driver genes, CCR4 and CC
Externí odkaz:
https://doaj.org/article/87b586d60b8342499a82f5af97ec17be
Autor:
Satoshi Nishiwaki, Shigeki Saito, Kyosuke Takeshita, Hidefumi Kato, Ryuzo Ueda, Akiyoshi Takami, Tomoki Naoe, Mika Ogawa, Takayuki Nakayama
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0242488 (2020)
Macrophages play an indispensable role in both innate and acquired immunity, while the persistence of activated macrophages can sometimes be harmful to the host, resulting in multi-organ damage. Macrophages develop from monocytes in the circulation.
Externí odkaz:
https://doaj.org/article/ed2a114db8044f46b9636f599b004754
Autor:
Shohei Mizuno, Ichiro Hanamura, Akinobu Ota, Sivasundaram Karnan, Jo Kanasugi, Ayano Nakamura, Souichi Takasugi, Kaori Uchino, Tomohiro Horio, Mineaki Goto, Satsuki Murakami, Mayuko Gotou, Hidesuke Yamamoto, Masaya Watarai, Masato Shikami, Yoshitaka Hosokawa, Hiroshi Miwa, Masafumi Taniwaki, Ryuzo Ueda, Masakazu Nitta, Akiyoshi Takami
Publikováno v:
FEBS Open Bio, Vol 8, Iss 12, Pp 1977-1991 (2018)
Chromosome band 8q24 is the most frequently amplified locus in various types of cancers. MYC has been identified as the primary oncogene at the 8q24 locus, whereas a long noncoding gene, PVT1, which lies adjacent to MYC, has recently emerged as anoth
Externí odkaz:
https://doaj.org/article/fce41036b929420d9e501181a4ef1468